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Appendix B Agenda The Science and Applications of Synthetic and Systems Biology March 14-15, 2011 Keck Building, Room 100 500 Fifth Street, NW Washington, DC DAY 1: MONDAY, MARCH 14, 2011 8:00–8:30 am Registration and Continental Breakfast 8:30–8:45 am Welcoming Remarks David Relman, M.D., Chair, and Jim Hughes, M.D., and Lonnie King, D.V.M., Vice-Chairs, Forum on Microbial Threats 8:45–9:30 am Keynote Remarks David Relman, Moderator Synthetic Biology and Biodefense Andrew Ellington, Ph.D., University of Texas at Austin 9:30–10:00 am Discussion 10:00–10:15 am Break 495
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496 SYNTHETIC AND SYSTEMS BIOLOGY SESSION 1: The Promise of Synthetic and Systems Biology for the Understanding and Management of Infectious Diseases Jesse Goodman, Moderator 10:15–10:45 am Synthetic biology, systems biology, and microbial threats James J. Collins, Ph.D., Boston University 10:45–11:15 am A metabolic engineering platform for discovery and production of new therapeutics Greg Stephanopoulos, Ph.D., Massachusetts Institute of Technology (MIT) 11:15–11:45 am Insights into pathogen-host interactions from systems biology Bernhard Palsson, Ph.D., University of California, San Diego 11:45–12:15 pm Commercial applications of synthetic biology David Berry, M.D., Ph.D., Flagship Ventures 12:15–12:45 pm Discussion 12:45–1:30 pm Lunch SESSION 2: “The Basics” of Synthetic Biology: Bottom-Up vs. Top-Down Approaches George Poste, Moderator 1:30–2:00 pm Systems for synthetic biology Hans Westerhoff, Ph.D., University of Manchester and the VU University Amsterdam 2:00–2:30 pm Design and complexity Herbert Sauro, Ph.D., University of Washington 2:30–3:00 pm DNA synthesis George Church, Ph.D., Harvard University 3:00–3:30 pm Synthetic biology “from scratch” Gerald Joyce, M.D., Ph.D., The Scripps Research Institute 3:30–3:45 pm Break
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497 APPENDIX B 3:45–4:15pm Protein engineering and high throughput immune function analyses for the discovery of the next generation of protein therapeutics George Georgiou, Ph.D., University of Texas at Austin 4: 15–4:45 pm Synthesis and installation of genomes Clyde Hutchison III, Ph.D., J. Craig Venter Institute 4:45–5:15 pm Access through refactoring: Rebuilding complex functions from the ground up Chris Voigt, Ph.D., University of California, San Francisco 5:15–6:00 pm Discussion 6:00 pm Meeting Adjourns DAY 2: TUESDAY, MARCH 15, 2011 8:45–9:15 am Continental breakfast 9:15–9:30 am Summary of Day One and Preview of Day Two: David Relman, M.D., Chair, Forum on Microbial Threats SESSION 3: Using Synthetic/Systems Biology Approaches to Manage Biofilms David Relman, Moderator 9:30–10:00 am Harnessing and controlling social activities of bacteria E. Peter Greenberg, Ph.D., University of Washington 10:00–10:30 am Developing a synthetic biology device that detects biofilm formation on indwelling catheters Paul Freemont, Prof., Imperial College London 10:30–10:45 am Break 10:45–11:15am Novel approaches to combat biofilm drug tolerance Kim Lewis, Ph.D., Northeastern University 11:15–11:45 am Engineering viruses to destroy biofilms Timothy Lu, M.D., Ph.D., Massachusetts Institute of Technology
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498 SYNTHETIC AND SYSTEMS BIOLOGY 11:45–12:15 pm Discussion 12:15–1:00 pm Lunch SESSION 4: Synthetic/Systems Biology Products and Platforms: Potential for Novel Preventives, Diagnostics, and Therapeutics in Infectious Diseases Kent Kester, Moderator 1:00–1:30 pm Engineering microbial metabolism for production of anti- malarial drugs Jay Keasling, Ph.D., University of California, Berkeley 1:30–2:00 pm Dynamics of clonal evolution: Immune system on a chip Jim Heath, Ph.D., California Institute of Technology 2:00–2:30 pm Using systems biology to understand and develop more effective vaccines Bali Pulendran, Ph.D., Emory University 2:30–2:45 pm Break 2:45–3:15 pm HTP screening system based on synthetic genes and proteins Stephen Johnston, Ph.D., Arizona State University 3:15–3:45 pm Synthetic biology and the art of biosensor design Chris French, Ph.D., University of Edinburgh 3:45–4:45 pm Open Discussion with Panelists, Forum Members, and Audience 4:45–5:00 pm Wrap-up Discussion, Jim Hughes and David Relman 5:00 pm Meeting Adjourns