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Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
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Appendix B

Agenda

The Science and Applications of Synthetic and Systems Biology

March 14-15, 2011
Keck Building, Room 100
500 Fifth Street, NW
Washington, DC

DAY 1: MONDAY, MARCH 14, 2011

8:00–8:30 am

Registration and Continental Breakfast

8:30–8:45 am

Welcoming Remarks

David Relman, M.D., Chair, and Jim Hughes, M.D., and Lonnie King, D.V.M., Vice-Chairs, Forum on Microbial Threats

8:45–9:30 am

Keynote Remarks

David Relman, Moderator

Synthetic Biology and Biodefense

Andrew Ellington, Ph.D., University of Texas at Austin

9:30–10:00 am

Discussion

10:00–10:15 am

Break

Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×

SESSION 1: The Promise of Synthetic and Systems Biology for the Understanding and Management of Infectious Diseases
Jesse Goodman, Moderator

10:15–10:45 am

Synthetic biology, systems biology, and microbial threats

James J. Collins, Ph.D., Boston University

10:45–11:15 am

A metabolic engineering platform for discovery and production of new therapeutics

Greg Stephanopoulos, Ph.D., Massachusetts Institute of Technology (MIT)

11:15–11:45 am

Insights into pathogen-host interactions from systems biology

Bernhard Palsson, Ph.D., University of California, San Diego

11:45–12:15 pm

Commercial applications of synthetic biology

David Berry, M.D., Ph.D., Flagship Ventures

12:15–12:45 pm

Discussion

12:45–1:30 pm

Lunch

SESSION 2: “The Basics” of Synthetic Biology: Bottom-Up vs. Top-Down Approaches
George Poste, Moderator

1:30–2:00 pm

Systems for synthetic biology

Hans Westerhoff, Ph.D., University of Manchester and the VU University Amsterdam

2:00–2:30 pm

Design and complexity

Herbert Sauro, Ph.D., University of Washington

2:30–3:00 pm

DNA synthesis

George Church, Ph.D., Harvard University

3:00–3:30 pm

Synthetic biology “from scratch”

Gerald Joyce, M.D., Ph.D., The Scripps Research Institute

3:30–3:45 pm

Break

Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×

3:45–4:15pm

Protein engineering and high throughput immune function analyses for the discovery of the next generation of protein therapeutics

George Georgiou, Ph.D., University of Texas at Austin

4: 15–4:45 pm

Synthesis and installation of genomes

Clyde Hutchison III, Ph.D., J. Craig Venter Institute

4:45–5:15 pm

Access through refactoring: Rebuilding complex functions from the ground up

Chris Voigt, Ph.D., University of California, San Francisco

5:15–6:00 pm

Discussion

6:00 pm

Meeting Adjourns

DAY 2: TUESDAY, MARCH 15, 2011

8:45–9:15 am

Continental breakfast

9:15–9:30 am

Summary of Day One and Preview of Day Two: David

Relman, M.D., Chair, Forum on Microbial Threats

SESSION 3: Using Synthetic/Systems Biology Approaches to Manage Biofilms
David Relman, Moderator

9:30–10:00 am

Harnessing and controlling social activities of bacteria

E. Peter Greenberg, Ph.D., University of Washington

10:00–10:30 am

Developing a synthetic biology device that detects biofilm formation on indwelling catheters

Paul Freemont, Prof., Imperial College London

10:30–10:45 am

Break

10:45–11:15am

Novel approaches to combat biofilm drug tolerance

Kim Lewis, Ph.D., Northeastern University

11:15–11:45 am

Engineering viruses to destroy biofilms

Timothy Lu, M.D., Ph.D., Massachusetts Institute of Technology

Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×

11:45–12:15 pm

Discussion

12:15–1:00 pm

Lunch

SESSION 4: Synthetic/Systems Biology Products and Platforms: Potential for Novel Preventives, Diagnostics, and Therapeutics in Infectious Diseases
Kent Kester, Moderator

1:00–1:30 pm

Engineering microbial metabolism for production of antimalarial drugs

Jay Keasling, Ph.D., University of California, Berkeley

1:30–2:00 pm

Dynamics of clonal evolution: Immune system on a chip

Jim Heath, Ph.D., California Institute of Technology

2:00–2:30 pm

Using systems biology to understand and develop more effective vaccines

Bali Pulendran, Ph.D., Emory University

2:30–2:45 pm

Break

2:45–3:15 pm

HTP screening system based on synthetic genes and proteins

Stephen Johnston, Ph.D., Arizona State University

3:15–3:45 pm

Synthetic biology and the art of biosensor design

Chris French, Ph.D., University of Edinburgh

3:45–4:45 pm

Open Discussion with Panelists, Forum Members, and Audience

4:45–5:00 pm

Wrap-up Discussion, Jim Hughes and David Relman

5:00 pm

Meeting Adjourns

Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×
Page 495
Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×
Page 496
Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×
Page 497
Suggested Citation:"Appendix B: Agenda." Institute of Medicine. 2011. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13239.
×
Page 498
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Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases.

The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

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