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from those journals. PubMed Central, which is a bit younger than MEDLINE, had about 1.8 million full-text peer-reviewed journal articles, and it gets about 300,000 users each day who are either accessing or downloading copies of those articles. There has been phenomenal growth in GenBank, which had on the order of 100 billion base pairs and about 100 million full sequences. Its rapid expansion reflects the deluge of information that must be captured, collected, curated, and maintained over time. As of October 2009, the clinical trials database had descriptive information on about 80,000 registered trials with information on 340 trials being added each week. We now have details on the results of these trials coming in at the rate of about 200 results records a month, so over time this will grow to be a fairly substantial resource for different kinds of comparative effectiveness research and for other kinds of evidence-based medicine research. With all of these databases, we notice that as we add content, the amount of use goes up.

Most of the databases that I have mentioned so far contain information that spans the spectrum of biomedical research and is accessed by a broad range of users—researchers, care providers, and the general public. We also have databases with information that is tailored for particular types of research and/or specific audiences. For example, our Influenza Virus Resource database (Figure 13–1) pulls literature from PubMed and PubMed Central as well as a variety of genome sets, some of which are generated by researchers associated with the National Institute for Allergies and Infectious Diseases. Thanks to their influenza genome sequencing project, we have now about 90,000 influenza genes and 2,000 full influenza sequences in the database.


FIGURE 13–1 Screen shot of the Influenza Virus Resource database. SOURCE: National Center for Biotechnology Information, National Institutes of Health

NLM has also been working to develop channels for getting out information about H1N1 influenza faster than typically occurs through traditional publication channels.

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