Effects:
Concentration (ppm): Mortality
9 0/10
18 7/10
124 10/10
382 10/10
822 10/10
2,342 10/10
End point/Concentration/Rationale: Exposure at 9 ppm for 1 h did not result in mortality; all exposed rats exhibited clinical signs of eye and mucosa irritation, dyspnea, gasping, and acute depression; necropsy revealed that the mouth and nasal mucosa were inflamed.
Uncertainty factors/Rationale:
Total uncertainty factor: 10
Interspecies: 3 was applied because perchloromethyl mercaptan is highly irritating and corrosive, and much of the toxicity is probably caused by a direct chemical effect on the tissues; this type of port-of-entry effect is not expected to vary greatly among species.
Intraspecies: 3 was applied because perchloromethyl mercaptan is highly irritating and corrosive, and much of the toxicity is probably caused by a direct chemical effect on the tissues; this type of port-of-entry effect is not expected to vary greatly among individuals; also supported by the steep dose-response curve, which may be an indication of little variation within a population.
Modifying factor: Not applicable
Animal-to-human dosimetric adjustment: Insufficient data
Time-scaling: Cn × t = k, where n = 3 for extrapolation from longer to shorter durations and n = 1 for extrapolation from shorter to longer durations.
Data adequacy: The AEGL-3 value was based on a concentration not causing lethality and should be protective of human health.


The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement