For a microbial pesticide to be registered by EPA for use in the United States, a variety of tests and reports are required, for example, on product analysis, pesticide residues, toxicology, effects on nontarget organisms, and environmental fate of the pesticide. Such testing is required for each strain of a mycoherbicide to be registered. An environmental assessment or an environmental impact statement would probably be required for each mycoherbicide and perhaps for each strain.
At the international level, applicable guidelines and potential limitations for testing, approval, and application of mycoherbicides against illicit crops fall under the International Plant Protection Convention, the International Standards for Phytosanitary Measures, the Biological Weapons Convention of 1972, and legal requirements in the country where the mycoherbicides would be used. Collectively, the guidelines are intended to prevent the spread and introduction of plant pests by requiring their safe export, import, shipment, and release. Some of the requirements involve documentation for the transport of agents, conducting risk assessments, and implementing risk-management strategies.