Institute. While at Bristol-Myers Squibb, she was the project team leader for the cancer-fighting drug Taxol.

Dr. Desmond-Hellmann also has served as associate adjunct professor of epidemiology and biostatistics at UCSF. During her tenure at UCSF, she spent two years as visiting faculty at the Uganda Cancer Institute, studying HIV/ AIDS and cancer. She also spent two years in private practice as a medical oncologist before returning to clinical research.

In January 2009, Desmond-Hellmann joined the Federal Reserve Bank of San Francisco’s Economic Advisory Council for a three-year term. In July 2008, she was appointed to the California Academy of Sciences board of trustees. Dr. Desmond-Hellmann was named to the Biotech Hall of Fame in 2007 and as the Healthcare Businesswomen’s Association Woman of the Year for 2006. She was listed among Fortune magazine’s “top 50 most powerful women in business” in 2001 and from 2003 to 2008. In 2005 and 2006, the Wall Street Journal listed dr. Desmond-Hellmann as one of its “women to watch.” From 2005 to 2008, Dr. Desmond-Hellmann served a three-year term as a member of the American Association for Cancer Research board of directors, and from 2001 to 2009, she served on the executive committee of the board of directors of the Biotechnology Industry Organization. She served on the corporate board of Affymetrix from 2004–2009.

Charles L. Sawyers, M.D., is an Investigator of the Howard Hughes Medical Institute and the inaugural Director of the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan-Kettering Cancer Center (MSKCC), where he is building a program of lab-based translational researchers across various clinical disciplines and institutional infrastructure to enhance the application of global genomics tools to clinical trials.

Dr. Sawyers’ laboratory is currently focused on characterizing signal transduction pathway abnormalities in prostate cancer, with an eye toward translational implications. His research is best demonstrated through his earlier studies of BCR-ABL tyrosine kinase function in chronic myeloid leukemia, his work with Brian Druker and Novartis in the development of the kinase inhibitor imatinib/Gleevec as primary therapy for CML, and his discovery that imatinib resistance is caused by BCR-ABL kinase domain mutations. This discovery led Dr. Sawyers to evaluate second-generation Abl kinase inhibitors, such as the dual Src/Abl inhibitor dasatinib, which received fast-track approval at the FDA in June 2006.

Dr. Sawyers’ work in prostate cancer has defined critical signaling pathways for disease initiation and progression through studies in mouse models and humane tissues. This preclinical work led to the development of a novel antiandrogen MVD3100, a small molecule inhibitor discovered in collaboration with UCLA Chemist Michael Jung, which targets the increased levels of androgen receptor found in the hormone refractory disease. Based on impressive



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