to 1999 she was vice dean for Academic Affairs and Faculty, Johns Hopkins University School of Medicine, and from 1994 to 2000, she was editor of Archives of Pediatrics and Adolescent Medicine. She also has been a member of numerous journal editorial boards. She has authored or edited 11 books on pediatrics and medical education and has published more than 250 peer-reviewed articles, chapters, and editorials. Most of her recent publications have focused on conflict of interest in medicine, on professionalism and integrity in medicine, on women in medicine, and on medical education. Dr. DeAngelis is a former council member of the National Academy of Sciences, Institute of Medicine; a fellow of the American Association for the Advancement of Science; and a fellow of the Royal College of Physicians. She has served as an officer of numerous national academic societies, including past chair of the American Board of Pediatrics and chair of the Pediatric Accreditation Council for Residency Review Committee of the American Council on Graduate Medical Education. She currently serves on the Advisory Board of the U.S. Government Accountability Office. She received her M.D. from the University of Pittsburgh’s School of Medicine, her M.P.H. from the Harvard Graduate School of Public Health (Health Services Administration), and her pediatric specialty training at the Johns Hopkins Hospital. She also has been awarded seven honorary doctorate degrees and has received numerous awards for humanitarianism and medical excellence.

David L. DeMets, Ph.D., is currently professor in the Department of Bio-statistics and Medical Informatics at the University of Wisconsin–Madison. Since receiving his Ph.D. from the University of Minnesota, he has been very active in the design, conduct, and analysis of clinical trials in several disease areas. Following a postdoctoral appointment at the National Institutes of Health (NIH) (1970-1972), he spent 10 years (1972-1982) at the National Heart, Lung, and Blood Institute, where he became chief of the Biostatistics Research Branch. In 1982, he joined the University of Wisconsin School of Medicine, where he founded and chaired the Department of Biostatistics and Medical Informatics until 2009. He is currently assistant director for Biostatistics and Medical Informatics for the University of Wisconsin Institute for Clinical and Translational Research, funded in part by NIH. He has coauthored or edited four texts, including Fundamentals of Clinical Trials, now in its fourth edition, as well as texts on statistical methods for clinical trials, principles for data monitoring committees, and case studies for data monitoring. Dr. DeMets is a recognized international leader in statistical research and methods for the analysis of clinical trials. He has collaborated in the development of statistical methods for the sequential analysis of outcome data and the design of clinical trials. He has extensive national and international clinical trial experience and has served on and chaired



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