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Acronyms and Abbreviations ACR acute cellular rejection AHRQ Agency for Healthcare Research and Quality ALK anaplastic lymphoma kinase ASCO American Society of Clinical Oncology BCBS Blue Cross Blue Shield CAD coronary artery disease CAP College of American Pathologists CARGO Cardiac Allograft Rejection Gene Expression Observational CDC Centers for Disease Control and Prevention CI confidence interval CLIA Clinical Laboratory Improvement Amendments of 1988 CMF cyclophosphamide, methotrexate, and fluorouracil CMS Centers for Medicare & Medicaid Services CMV cytomegalovirus COI conflict of interest CONSORT Consolidated Standards of Reporting Trials CPRC Cancer Center Protocol Review Committee CTAF California Technology Assessment Forum CTMS clinical trial management systems CTSA Clinical Translational Science Award dbGaP database of Genotypes and Phenotypes DNA deoxyribonucleic acid 323
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324 EVOLUTION OF TRANSLATIONAL OMICS DOD Department of Defense DSMB data safety monitoring board EGAPP Evaluation of Genomic Applications in Practice and Prevention EMB endomyocardial biopsy EQUATOR Enhancing the QUAlity and Transparency Of health Research FDA Food and Drug Administration FFATA Federal Funding Accountability and Transparency Act FFPE formalin-fixed, paraffin-embedded FISH fluorescence in situ hybridization HER2 human epidermal growth factor receptor 2 HHS U.S. Department of Health and Human Services HPV human papillomavirus HR hazard ratio ICMJE International Committee of Medical Journal Editors IDE investigational device exemption IDMC independent data monitoring committee IHC immunohistochemistry IMAGE Invasive Monitoring Attenuation through Gene Expression IND investigational new drug IOM Institute of Medicine IOTF Interagency Oncology Task Force IRB Institutional Review Board ISHLT International Society for Heart and Lung Transplantation ISO International Organization for Standardization IVD in vitro diagnostic IVDMIA in vitro diagnostic multivariate index assay LDT laboratory-developed test LMS Lung Metagene Score MALDI matrix-assisted laser desorption/ionization MALDI-TOF time-of-flight mass spectrometer MF methotrexate and fluorouracil MIAME Minimum Information About a Microarray Experiment MIBBI Minimum Information for Biological and Biomedical Investigations
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325 ACRONYMS AND ABBREVIATIONS MINDACT Microarray In Node negative and 1-3 positive lymph node Disease may Avoid ChemoTherapy miRNA micro RNA MoS Manual of Style: A Guide for Authors and Editors MRI magnetic resonance imaging mRNA messenger RNA MS mass spectrometry NAS National Academy of Sciences NCCN National Comprehensive Cancer Network NCI National Cancer Institute ncRNA non-coding RNA NIH National Institutes of Health NIST National Institute of Standards and Technology NMR nuclear magnetic resonance NOCEDP National Ovarian Cancer Early Detection Program NRC National Research Council NSABP National Surgical Adjuvant Breast and Bowel Project OHRP Office of Human Research Protections ORI Office of Research Integrity PBMC peripheral blood mononuclear cells PHS Public Health Service PI principal investigator PMA premarket approval PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses PSA prostate-specific antigen QMS quality management systems qRT-PCR quantitative reverse-transcriptase polymerase chain reaction RCT randomized controlled trial REMARK REporting recommendations for tumor MARKer prognostic studies RNA ribonucleic acid RNAseq RNA sequencing rRNA ribosomal RNA RS Recurrence Score RT-PCR reverse-transcriptase polymerase chain reaction RxPONDER Rx for POsitive NoDe, Endocrine Responsive breast cancer
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326 EVOLUTION OF TRANSLATIONAL OMICS SELDI surface-enhanced laser desorption/ionization SELDI-TOF SELDI time-of-flight mass spectrometer SERMs selective estrogen receptor modulators SGO Society of Gynecologic Oncology SNP single nucleotide polymorphism SOP standard operating procedure SPCI Simone Protective Cancer Institute SQUIRE Standards for QUality Improvement Reporting Excellence SRM selected reaction monitoring SS similarity score STARD STAndards for the Reporting of Diagnostic accuracy studies STROBE STrengthening the Reporting of OBservational studies in Epidemiology TAILORx Trial Assigning IndividuaLized Options for Treatment TEC Blue Cross Blue Shield Technology Evaluation Center TMQF Translational Medicine Quality Framework tRNA transfer RNA USPSTF U.S. Preventive Services Task Force