G

Positron Emission Tomography Radiopharmaceuticals

 

TABLE G-1 Positron Emission Tomography Radiopharmaceuticals

Trade Name Radiopharmaceutical Clinical Indication

Ammonia N13

13N-Ammonia

Myocardial blood flow

Cardio-Gen

82Rb-Rubidium chloride

Myocardial blood flow

Florbetapir F18 **

18F-styryl-pyridine

Amyloid Plaques Alzheimer’s disease

Fluorbetabane F18#

18F-styryl-pyridine

Amyloid Plaques Alzheimer’s disease

Flutemetamol F18#

18F-hydroxy-benzothiazole

Amyloid Plaques Alzheimer’s disease

Fluorpiridaz F18#

18F-pyridazinone

Myocardial blood flow

Fludeoxyglucose F18 Injection

18F-Fluorodeoxyglucose

Oncology,Myocardial Viability, Seizure Foci

Sodium Fluoride F18

Sodium 18F-fluoride

Bone scans



Single Photon Emission Computed Tomography (SPECT) Radiopharmaceuticals

Chromitope Mallinkrodt Cr-51

Sodium 51Cr-chromate

Red Blood Cell Labeling

Ga-67

67Ga-Gallium citrate

Soft tissue tumor, Inflammatory processes

Indium In 111 oxyquinoline

111In-Indium oxyquinoline

Luekocyte and platlet labeling

MPI Indium DTPA In 111

111In-Indium Pentetate disodium

Cerebrospinal fluid kinetics

ProstaScint

111In-Indium Capromab Pendetide

Prostate Tumor

Octreoscan

111In-Indium Pentetreotide

Neuroendocrine tumors Gastroenteropancreatic tumors

Zevalin

111In -Ibitumonmab iuxetan

non-Hodgkin’s lymphoma

Sodium Iodide I 123

Sodium 123I-iodide

Thyroid uptake

Datscan

123I-Ioflupane

Striatal Dopaminae Transporters

Adreview

123I-Iobenguane

Pheochromacytoma, Neuroblastoma

Glofil

125I-Iothalamate

Glomerular filtration measurement

Jeanatope

125I-human Serum Albumin

Total blood and plasma volume

Megatope

131I-human Serum Albumin

Total blood and plasma volume

Bexxar

131I-Tositumomab

non-Hodgkin’s lymphoma

Sodium Iodide I 123

Sodium 123I-iodide

Thyroid uptake

Technetium Generator

99mTc-Pertechnetate

Thyroid, salivary and parathyroid

Technelite

   glands, ectopic gastric mucosa,

Ultra-Technekow FM

   dacryocystography, cystography

Neurolite

99mTc-Bicisate (ECD)

Cerebral Perfusion

Hepatolite-CIS

99mTc-Disofenin (DISIDA)

Hepatobiliary function

Ceretec

99mTc-Exametazine (HMPAO)

Cerebral Perfusion



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OCR for page 193
G Positron Emission Tomography Radiopharmaceuticals TABLE G-1 Positron Emission Tomography Radiopharmaceuticals Trade Name Radiopharmaceutical Clinical Indication Ammonia N13 N-Ammonia Myocardial blood flow 13 Cardio-Gen Rb-Rubidium chloride Myocardial blood flow 82 Florbetapir F18 ** F-styryl-pyridine Amyloid Plaques Alzheimer’s disease 18 Fluorbetabane F18# F-styryl-pyridine Amyloid Plaques Alzheimer’s disease 18 Flutemetamol F18# F-hydroxy-benzothiazole Amyloid Plaques Alzheimer’s disease 18 Fluorpiridaz F18# F-pyridazinone Myocardial blood flow 18 Fludeoxyglucose F18 Injection F-Fluorodeoxyglucose Oncology,Myocardial Viability, Seizure Foci 18 Sodium Fluoride F18 Sodium 18F-fluoride Bone scans Single Photon Emission Computed Tomography (SPECT) Radiopharmaceuticals Chromitope Mallinkrodt Cr-51 Sodium 51Cr-chromate Red Blood Cell Labeling Ga-67 Ga-Gallium citrate Soft tissue tumor, Inflammatory processes 67 Indium In 111 oxyquinoline In-Indium oxyquinoline Luekocyte and platlet labeling 111 MPI Indium DTPA In 111 In-Indium Pentetate disodium Cerebrospinal fluid kinetics 111 ProstaScint In-Indium Capromab Prostate Tumor 111 Pendetide Octreoscan In-Indium Pentetreotide Neuroendocrine tumors 111 Gastroenteropancreatic tumors Zevalin In -Ibitumonmab iuxetan non-Hodgkin’s lymphoma 111 Sodium Iodide I 123 Sodium 123I-iodide Thyroid uptake Datscan I-Ioflupane Striatal Dopaminae Transporters 123 Adreview I-Iobenguane Pheochromacytoma, Neuroblastoma 123 Glofil I-Iothalamate Glomerular filtration measurement 125 Jeanatope I-human Serum Albumin Total blood and plasma volume 125 Megatope I-human Serum Albumin Total blood and plasma volume 131 Bexxar I-Tositumomab non-Hodgkin’s lymphoma 131 Sodium Iodide I 123 Sodium 123I-iodide Thyroid uptake Technetium Generator Tc-Pertechnetate Thyroid, salivary and parathyroid 99m Technelite glands, ectopic gastric mucosa, Ultra-Technekow FM dacryocystography, cystography Neurolite Tc-Bicisate (ECD) Cerebral Perfusion 99m Hepatolite-CIS Tc-Disofenin (DISIDA) Hepatobiliary function 99m Ceretec Tc-Exametazine (HMPAO) Cerebral Perfusion 99m (continued) 193

OCR for page 193
194 ASSURING A FUTURE U.S.-BASED NUCLEAR AND RADIOCHEMISTRY EXPERTISE TABLE G-1 Continued Trade Name Radiopharmaceutical Clinical Indication Pulmolite Tc-Aggregated albumin Pulmonary Perfusion 99m Technetium Tc 99M Albumin Aggregated Kit Choletec Tc-Mebrofenin Hepatobiliary function 99m Osteolite Tc-Medronate (MDP) Bone imaging 99m Technescan MAG3 Tc-Mertiatide Renal function 99m Techneplex DTPA Tc-Pentetate Renal function, Radioaresol ventilation 99m Phosphotec Pyrolite Pyro Tc-Pyrophosphate (PYP) Infarct imaging, in vivo Red blood cell 99m Technescan PYP Amersham labeling PYP Cardiolite Miraluma Tc-Sestamibi Myocardial blood flow, Breast tumor 99m DMSA Tc-Succimer (DMSA) Renal function 99m Sulfur Colloid Tc-Sulfur Colloid Liver/spleen gastric emptying, GI bleeds 99m AN-Sulfur Colloid Myoview Tc-Tetrofosmin Myocardial blood flow 99m Thallium Tl-Thallium chloride Myocardial blood flow, Parathyroid, Tumor 201 Xenon Xe-xenon gas Pulmonary ventilation 133 Radiotherapeutics Zevalin Y-Ibitumonmab Tiuxetan non-Hodgkin’s lymphoma 90 Bexaar I-Tositumomab non-Hodgkin’s lymphoma 131 Metastron Sr-strontium bone pain from skeletal metastases 89 Quadramet Sm Lexidronin bone pain from skeletal metastases 153 Sodium Iodide I 131 Sodium 131I-iodide Thyroid therapy HICON Phosphocol 32 P-Chromicphosphate Intracavity malignancies 32 ** Conditionally approved by the FDA # in Phase 3 clinical trials SOURCE: NRC/IOM 2007; FDA 2011; UAMS 2011 REFERENCES FDA (U.S. Food and Drug Administration). 2011. Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. U.S. Food and Drug Administration [online]. Avail- able: http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm [accessed November 21, 2011]. NRC/IOM (National Research Council and Institute of Medicine). 2007. Appendix C. Com- mercially available radiopharmaceuticals. Pp. 151-154 in Advancing Nuclear Medicine through Innovation. Washington, DC: The National Academies Press. UAMS (University of Arkansas for Medical Sciences). 2011. Radiopharmaceutical List and Package Inserts. Nuclear Pharmacology, College of Pharmacy, University of Arkansas for Medical Sciences [online]. Available: http://nuclearpharmacy.uams.edu/resources/ PackageInserts.asp [accessed October 24, 2011].