Trade Name Radiopharmaceutical Clinical Indication

Pulmolite

99mTc-Aggregated albumin

Pulmonary Perfusion

Technetium Tc 99M Albumin Aggregated Kit

Choletec

99mTc-Mebrofenin

Hepatobiliary function

Osteolite

99mTc-Medronate (MDP)

Bone imaging

Technescan MAG3

99mTc-Mertiatide

Renal function

Techneplex DTPA

99mTc-Pentetate

Renal function, Radioaresol ventilation

Phosphotec Pyrolite Pyro Technescan PYP Amersham PYP

99mTc-Pyrophosphate (PYP)

Infarct imaging, in vivo Red blood cell labeling

Cardiolite Miraluma

99mTc-Sestamibi

Myocardial blood flow, Breast tumor

DMSA

99mTc-Succimer (DMSA)

Renal function

Sulfur Colloid

99mTc-Sulfur Colloid

Liver/spleen gastric emptying, GI bleeds

AN-Sulfur Colloid

Myoview

99mTc-Tetrofosmin

Myocardial blood flow

Thallium

201Tl-Thallium chloride

Myocardial blood flow, Parathyroid, Tumor

Xenon

133Xe-xenon gas

Pulmonary ventilation

Radiotherapeutics

Zevalin

90Y-Ibitumonmab Tiuxetan

non-Hodgkin’s lymphoma

Bexaar

131I-Tositumomab

non-Hodgkin’s lymphoma

Metastron

89Sr-strontium

bone pain from skeletal metastases

Quadramet

153Sm Lexidronin

bone pain from skeletal metastases

Sodium Iodide I 131

Sodium 131I-iodide

Thyroid therapy

HICON

Phosphocol 32

32P-Chromicphosphate

Intracavity malignancies

** Conditionally approved by the FDA

# in Phase 3 clinical trials

SOURCE: NRC/IOM 2007; FDA 2011; UAMS 2011

REFERENCES

FDA (U.S. Food and Drug Administration). 2011. Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. U.S. Food and Drug Administration [online]. Available: http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm [accessed November 21, 2011].

NRC/IOM (National Research Council and Institute of Medicine). 2007. Appendix C. Commercially available radiopharmaceuticals. Pp. 151-154 in Advancing Nuclear Medicine through Innovation. Washington, DC: The National Academies Press.

UAMS (University of Arkansas for Medical Sciences). 2011. Radiopharmaceutical List and Package Inserts. Nuclear Pharmacology, College of Pharmacy, University of Arkansas for Medical Sciences [online]. Available: http://nuclearpharmacy.uams.edu/resources/PackageInserts.asp [accessed October 24, 2011].



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