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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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Appendix B

Workshop Agenda

U.S. AND EUROPEAN ANIMAL RESEARCH REGULATIONS: IMPACT ON NEUROSCIENCE RESEARCH

July 26-27, 2011
Kavli Royal Society International Centre, Chicheley Hall Buckinghamshire, United Kingdom

Background: Numerous regulations, laws, directives, and policies are in place to ensure the ethical use of animals in medical and life sciences research. These regulations are intended to ensure that humane care and use is provided to animals in research and that practical steps are taken to use the smallest number of animals to give significant results while ensuring that each individual animal experiences minimum pain or distress. The goal of the workshop is to bring together researchers, legal scholars, administrators, and other key stakeholders to discuss current trends and differences in animal regulations. Particular attention will be paid to identifying potential implications of new regulations on neuroscience research. The workshop will also provide an opportunity for international dialog about engaging public opinion regarding animal use in research and the development of core principles and outcomes for animal care and use.

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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Meeting Objectives:

With particular reference to neuroscience research, to:

 

•   Identify and discuss international differences in animal research regulations:

      o   Discuss current and emerging issues.

•   Discuss legal trends and activity in the courts that may impact research.

•   Examine the implications of regulations on the neuroscience research enterprise.

•   Discuss current communication strategies regarding animal research.

•   Explore the feasibility of developing a set of global core principles and outcomes for animal care and use.

DAY ONE

8:00 a.m.

Breakfast

8:30 a.m.

Welcome, Introductions, and Objectives
COLIN BLAKEMORE, Co-Chair
ARTHUR SUSSMAN, Co-Chair

   
8:45 a.m.

Animal Research in the Neurosciences
COLIN BLAKEMORE

SESSION I: CURRENT REGULATIONS AND EMERGING ISSUES

Session Objective: Highlight current animal research regulations, policies, and guidance. Review differences in approaches to regulations and practices exemplified by the United States and European Union and new regulations currently being proposed in emerging regions (e.g., Asia and South America). Include a review of current and emerging issues in animal research regulations.

9:15 a.m.

Overview and Session Objectives
JUDY MacARTHUR CLARK, Session Chair

   
9:25 a.m.

Europe
KARIN BLUMER
Scientific Affairs
Novartis, Switzerland

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
9:50 a.m.

United States
TAYLOR BENNETT
Senior Scientific Advisor
National Association for Biomedical Research

   
10:15 a.m.

Asia
JIANFEI WANG
Director, Laboratory Animal Science
GlaxoSmithKline, R&D China

   
10:40 a.m.

South America
EKATERINA RIVERA
Professor, Biological Sciences Institute
University of Goias

   
11:05 a.m.

Panel Discussion with Speakers and Participants:

•   What is the basis for regulatory differences among countries?

•   What are emerging key issues surrounding animal research regulations?

   
12:00 p.m.

LUNCH

SESSION II: IMPACT OF LEGAL TRENDS ON ANIMAL RESEARCH

Session Objective: Discuss changes to laws regarding animal rights on regulations and research. Explore emerging laws and legal strategies that have the potential to directly influence the use of animals in medical research.

1:15 p.m.

Overview and Session Objectives ARTHUR SUSSMAN, Session Chair

   
1:25 p.m.

Animal Rights Laws

•   Examine the interplay between the legal system and animal use regulatory system.

•   What are the potential implications of changes in regulations to the legal rights of animals? Research?

•   What are current trends, United States versus European differences?

       MARGARET FOSTER RILEY
            Professor
            University of Virginia, School of Law

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
1:45 p.m.

Freedom of Information and Openness

•   How are these laws being used by the animal rights movement?

•   Are there limitations to the type of information that can be obtained?

•   Can greater transparency lead to less effort needed in response to Freedom of Information Act demands?

     MARGARET SNYDER
           Freedom of Information Act Coordinator
           Office of Extramural Research
           National Institutes of Health

   
2:05 p.m.

State Sunshine Laws

•   How are these laws being used by the animal rights movement?

•   Are there limitations to the type of information that can be obtained?

•   Can greater transparency reduce requests for information?

     RICHARD CUPP
           John W. Wade Professor of Law
           Pepperdine Law School

   
2:15 p.m.

Discussion with Speakers and Participants

   
2:40 p.m.

BREAK

SESSION III: THE IMPACT OF REGULATIONS ON ANIMAL-BASED NEUROSCIENCE RESEARCH

Session Objective: Discuss the impact of current regulations, policies, guidance, and economic considerations on the conduct of animal-based neuroscience research. Consider the role that animals have played in neuroscience research: the benefits achieved, but also the costs. Include examination of the administrative load and economic cost associated with animal research regulations and response of researchers and funders to cost implications.

3:10 p.m.

Overview and Session Objectives
ROBERTO CAMINITI, Session Chair

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
3:20 p.m.

Panelists:

Use of Rodent Models in Neuroscience
      BILL YATES
      Professor
      University of Pittsburgh

When Should Non-Human Primates Be Used as Animal Models?
      ROGER LEMON
      Sobell Chair of Neurophysiology
      University College London Institute of Neurology

The Ethical and Practical Dilemmas of Research on Non-Human Primates
      STUART ZOLA
      Director
      Yerkes National Primate Research Center

Administrative and Economic Costs
      CHARLES J. HECKMAN
      Professor
      Northwestern University Feinberg School of Medicine

   
4:40 p.m.

Discussion with Speakers and Participants:

•  How has the implementation of current and new regulations impacted the speed and quality of research, positively and negatively?

•  Has the pressure for reduction of numbers, use of “lower†species, reduction of cost, and replacement of animals distorted the balance of neuroscience research in ways that impede the rate of discovery?

•  How can we assess costs to animals, especially cumulative severity in long-term animal studies, including NHPs?

•  How can administrators and scientists work together to balance the economic costs of animal research regulations while maintaining public confidence?

   
5:30 p.m.

ADJOURN AND DINNER IN THE HALL’S DINING ROOM

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

DAY TWO

8:00 a.m. Breakfast

SESSION IV: IMPACT OF 3Rs ON THE NEUROSCIENCE RESEARCH ENTERPRISE

Session Objective: Examine experiences of applying the 3Rs (replacement, refinement, and reduction) in neuroscience research, including consideration of opportunities for enhanced scientific outcomes as well as welfare benefits and potential limitations. Examine the influence that non-researchers and others have on neuroscience researchers working with animals. Consider the role of systematic reviews, or the review and synthesis of all relevant studies by the application of scientific strategies.

8:30 a.m. Overview and Session Objectives
    COLIN BLAKEMORE, Session Chair
   
8:40 a.m. Panelists:

Replacement Strategies in Neuroscience Research: Focus on Spinal Cord Injury
      SUE BARNETT
      Professor of Cellular Neuroscience
      University of Glasgow

Refinement and Reduction Strategies: Improving Models
of Disease and Using Translational Approaches in Epilepsy
and Parkinson’s Disease
      GAVIN WOODHALL
      Reader in Neuropharmacology
      ston University

The Role of Systematic Reviews
      ANNE MURPHY
      Associate Professor
      University of California, San Diego

Future Considerations and Impact of 3Rs
      JACKIE HUNTER
      OI Pharma Partners

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
10:20 a.m. Discussion with Speakers and Participants:

•   How can the 3Rs best be used effectively to deliver advancements in neuroscience?

•   For what areas of neuroscience research is replacement a realistic long-term goal? How can this objective be most effectively pursued?

•   Are current regulations causing neuroscientists to move away from animal work or to use less strictly regulated models?

•   Are new regulations impeding the progress of neuroscience, or leading to neuroscience advancements?

•   Is collaboration between sectors (industry/academia) effec tive and what is the impact of greater globalization of research?

•   Critical analysis of systematic reviews—do they play a role? If so, should there be a new approach to experimental design to facilitate such reviews?

   
11:00 a.m. BREAK

SESSION V: ENGAGING AND INFORMING THE PUBLIC

Session Objective: Provide an opportunity for international dialog around communication strategies regarding animal use in research. Examine successes and failures in the engagement of the public, politicians, and the media in productive discussions of the use of animals in research. Identify opportunities to educate non-researchers in the animal use regulatory system.

11:15 a.m. Overview and Session Objectives
    FRANKIE TRULL, Session Chair
11:25 a.m. Panelists:

   Neuroscientist
      RANDALL NELSON
      Professor
      The University of Tennessee Health Science Center

   Science Writer
      MARK HENDERSON
      Science Correspondent
      The Times

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

   Patient Group Administrator
      TIM COETZEE
      Chief Research Officer
      National Multiple Sclerosis Society

12:25 p.m. Discussion with Speakers and Participants:

•   What is the responsibility of individual scientists, patient groups, and organizations to engage the public in dialogue about animal research?

•   Are there teachable examples of successful engagement and dialogue by animal researchers with the public?

   
1:00 p.m. LUNCH

SESSION VI: CORE PRINCIPLES FOR ANIMAL RESEARCH REGULATION

Session Objective: Provide an opportunity for international dialog around communication strategies regarding animal use in research. Examine successes and failures in the engagement of the public, politicians, and the media in productive discussions of the use of animals in research. Identify opportunities to educate non-researchers in the animal use regulatory system.

2:00 p.m. Overview and Session Objectives
   RICHARD NAKAMURA, Session Chair
11:25 a.m. Panelists:

    European Government Regulator
        JUDY MacARTHUR CLARK
        Chief Inspector
        UK Home Office

   U.S. Government Regulator
        PATRICIA BROWN
        Director
        Office of Laboratory Animal Welfare

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

   Industry Representative
        MARGARET LANDI
        Vice President, Global Laboratory Animal Science;
        Chief of Animal Welfare and Veterinary Medicine
        GSK Pharmaceuticals

   ILAR Council Member
        TIMO
        NEVALAINEN
        Professor
        University of Eastern Finland

3:30 p.m. Discussion with Speakers and Participants:

•   Are there core principles and outcomes specific to regulations for animal use in neuroscience research?

   
4:15 p.m. MEETING WRAP-UP WITH SESSION CHAIRS

 

Panelists:
Session I:      JUDY MacARTHUR CLARK
Session II:     ARTHUR SUSSMAN
Session III:    ROBERTO CAMINITI
Session IV:    COLIN BLAKEMORE
Session V:     FRANKIE TRULL
Session VI:    RICHARD NAKAMURA

   
5:00 p.m. FINAL REMARKS
    COLIN BLAKEMORE, Co-Chair
    ARTHUR SUSSMAN, Co-Chair
   
5:30 p.m. ADJOURN
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×
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International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary Get This Book
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Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research.

To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

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