Representative Priorities or Interest Areas

Nongovernmental and Other Organizations: International vaccine initiatives, private foundations, and multinational groups.

• Cost-effectiveness and effective implementation for each vaccine.

• Special attention for countries with poor resources.

• Logistics of vaccine delivery with a regional and local resolution than a national focus.

• Consideration of operational criteria for vaccines—availability of cold chain and trained human resources.

• Consideration of public perception of risk and the acceptance of vaccines.

• Availability of effective surveillance strategies and technologies.

• Alternative methods to prevent the disease.

• Availability of sufficient number of doses of quality vaccines for distribution.

trials performed sequentially. The requirement for sequential trials further extends the development period and cost.

With the newest technologies, however, the hope is that the development of new vaccines can be accelerated. Systems biology and the adaptive design of clinical trials may help reduce development time by allowing more rapid identification of vaccine candidates and making it possible to conduct the exhaustive and monitored Phase I and Phase II trials in parallel (Rappuoli and Aderem, 2011).

Stakeholder priorities

Various stakeholders are involved in the development and deployment of vaccines. To better understand the different priorities of the public sector, private sector, and nongovernmental groups, the committee organized information-gathering sessions in meetings I and II. Representative priorities and interest areas are listed in Table 1-1.

It became clear to the committee that in order to create a broad-based decision framework that would be relevant to multiple stakeholders and communities, the committee needed to consider not only the vibrancy of the vaccine enterprise but also the specific needs and interests of these stakeholders. The modeling strategy of the committee is discussed in Chapter 2.

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