Chapter 2 of this report describes the planned chemical weapons destruction processes to be employed at the two ACWA demilitarization facilities and analyzes the probable secondary waste streams and planned waste treatment and disposal activities. Current Army methods for monitoring chemical agent contamination of secondary waste materials as well as equipment, machinery, and structural components during agent changeout and plant closure activities are first presented in Chapter 2 and then elaborated on in Chapter 3. Chapter 3 also presents potential scenarios in which real-time surface or condensed phase agent measurements might be useful. Chapter 4 reviews the current state of the art of analytical ambient ionization mass spectrometry and discusses potential analysis tasks and technology implementations. An analysis of statistical sampling design methods and information on their application to chemical agent surface contamination measurements in relevant chemical demilitarization plant scenarios are presented in Chapter 5. The committee’s findings and recommendations are compiled in Chapter 6. As previously indicated, Appendix A contains short biographical sketches of the committee members and Appendix B provides details of committee meeting activities. Appendix C lists some known current sources of commercially available ambient ionization mass spectrometry equipment in support of the technical presentation in Chapter 4. Appendix D on statistical calibration and Appendix E on sampling variability and uncertainty analyses supplement the statistical presentation in Chapter 5.