drug discovery and development. Chapter 3 examines three case studies as illustrations of both the promise and the challenges of genomic-based drug discovery and development. Chapter 4 looks at the application of emerging technologies, such as next-generation sequencing, to this field. Chapter 5 examines several specific evolving paradigms in genomic-based drug development, approval, and prescribing. Finally, Chapter 6 features comments and discussions drawn from throughout the workshop on overcoming the challenges and achieving the promise of genomic-based drug discovery and development.