record through the original submitting institution. The ability to acquire additional data may also be constrained by ethical and legal restrictions, such as privacy laws, as noted briefly below.

Consent from the source might be inadequate for use, permission to recontact might be lacking, or recontact might be prohibitively expensive.

Although the acquisition of additional clinical data for a case may be technically possible, there may be circumstances where it would be prohibited or restricted by ethical or legal issues related to recontact or privacy laws, including the federal Health Insurance Portability and Accountability Act of 1996 (PL 104-191, 110 Stat. 1936, and accompanying regulations). In other situations—especially where a number of years have passed since the data or specimen were collected—it may require extensive research to locate the source individual. Those issues may render specific cases unusable for some types of research. Chapter 3 addresses consent and other ethical, legal, and regulatory aspects of use of the JPC materials for consultative, educational, and research purposes.


Aebersold R, Mann M. 2003. Mass spectrometry-based proteomics. Nature 422(6928):198-207.

Akalu A, Reichardt JK. 1999. A reliable PCR amplification method for microdissected tumor cells obtained from paraffin-embedded tissue. Genetic Analysis 15:229-233.

Asterand. 2008. Assessment of the Department of Defense’s tissue repository located at the Armed Forces of Pathology in Washington DC. Detroit, MI: Asterand, Inc.

Azimzadeh O, Barjaktarovic Z, Aubele M, Calzada-Wack J, Sarioglu H, Atkinson MJ, Tapio S. 2010. Formalin-fixed paraffin-embedded (FFPE) proteome analysis using gel-free and gel-based proteomics. Journal of Proteome Research 9(9):4710-4720.

Bataille F, Troppmann S, Klebl F, Rogler G, Stoelcker B, Hofstadter F, Bosserhoff AK, Rummele P. 2006. Multiparameter immunofluorescence on paraffin-embedded tissue sections. Applied Immunohistochemistry & Molecular Morphology 14(2):225-228.

Beck AH, Weng Z, Witten DM, Zhu S, Foley JW, Lacroute P, Smith CL, Tibshirani R, van de Rijn M, Sidow A, West RB. 2010. 3-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS One 5(1):e8768.

Becker JS, Jakubowski N. 2009. The synergy of elemental and biomolecular mass spectrometry: New analytical strategies in life sciences. Chemical Societies Review 38(7):1969-1983.

Bischoff K, Lamm C, Erb HN, Hillebrandt JR. 2008. The effects of formalin fixation and tissue embedding of bovine liver on copper, iron, and zinc analysis. Journal of Veterinary Diagnostic Investigation 20(2):220-224.

Bonin S, Hlubek F, Benhattar J, Denkert C, Dietel M, Fernandez PL, Hofler G, Kothmaier H, Kruslin B, Mazzanti CM, Perren A, Popper H, Scarpa A, Soares P, Stanta G, Groenen PJ. 2010. Multicentre validation study of nucleic acids extraction from FFPE tissues. Virchows Archiv 457:309-317.

Botling J, Edlund K, Segersten U, Tahmasebpoor S, Engström M, Sundström M, Malmström PU, Micke P. 2009. Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue. Diagnostic Molecular Pathology 18(1):44-52.

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