FIGURE 2-1 Glycoscience research spans a diversity of fields, as indicated by the Web of Science subject categories associated with published research. Results from the WOS citation search described above were sorted by WOS subject category, and the top 20 subject areas are depicted above.

resources for glycomics profiling, carbohydrate compounds and reagents, microarray analysis, mouse phenotyping, glycan array screening, and glycan databases.

Similarly, a number of U.S. research programs and clusters of research expertise were identified during the committee’s data-gathering process. These span the country and may involve multiple researchers, providing a concentration of expertise across different aspects of glycoscience. Although many more examples are provided in Appendix B, one example of a center of excellence for glycoscience research in the United States is the Complex Carbohydrate Research Center (CCRC), located at the University of Georgia. The CCRC includes a cluster of centers that address plant, microbial, and human carbohydrates, along with research resources in areas such as nuclear magnetic resonance analysis and computational modeling.

Glycoscience research is also conducted across the globe in projects that cut across disciplines. Although not described here, examples of research activities and investments from Canada, the United Kingdom, Germany, Japan, China, Taiwan, Australia, New Zealand, and Brazil are provided in the appendix. Glycoscience also has significant relevance to companies invested in the development of protein-based biotherapeutics or vaccines containing carbohydrate antigens (discussed in Chapter 3). Other companies interested in glycoscience include those that use carbohydrate-based materials for drug delivery and tissue engineering applications, those interested in the development of cellulose-based biofuels and products derived from agricultural sources and by custom chemical producers. Representative examples are provided in Appendix B.

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