4.11   How Can Sugars Be Reassembled to Develop Materials with Tailored Properties and Functionality?

4.12   Summary

5     The Toolkit of Glycoscience

5.1     Synthesis

5.1.1     General Aspects

5.1.2     Synthetic Tools

5.1.3     Manipulating Glycans by Pathway Engineering

5.1.4     Synthesis of Standards for Mass Spectrometry

5.1.5     Key Messages on Glycan Synthesis

5.2     Analysis

5.2.1     Analysis of Primary Glycan Structures

5.2.2     Analysis of Glycoconjugates

5.2.3     Analysis of Glycan-Protein Interactions

5.2.4     Analysis of the Roles of Some Glycans in Metabolic Pathways Related to Energy Metabolism

5.2.5     Analysis Techniques That Relate Glycan Structures and Their Synthetic Enzymes

5.2.6     Analysis of Locations of Specific Glycan Structures in Organisms Through Various Imaging Techniques

5.2.7     Key Messages on Glycan Analysis

5.3     Computational Modeling

5.3.1     Computational Modeling of Oligo- and Polysaccharides

5.3.2     Protein-Glycan Interactions

5.3.3     Atomistic Modeling of Crystalline Cellulose

5.3.4     Key Messages on Computational Analysis of Glycans

5.4     Glycoenzymes

5.4.1     Classes of Glycoenzymes

5.4.2     Applications of Glycosyltransferases and Other Glycoenzymes

5.4.3     Key Messages on Glycoenzymes

5.5     Systems Glycobiology

5.6     Informatics and Databases

5.6.1     Limited Successes in Developing Broadly Available Informatics Tools

5.6.2     Critical Need for Development of a Single Integrated Database

5.6.3     Key Messages on Glycan Bioinformatics and Databases

5.7     Summary and Findings

The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement