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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This project was supported by the National Institutes of Health under contract N01-OD-4-2139, TO#251, the National Science Foundation under grant CHE-1138764, the U.S. Department of Energy under contract DE-SC0007069, the Food and Drug Administration under contract HHSF223200810020I, TO#HHSF22301023, and the Howard Hughes Medical Institute. The views expressed herein are those of the authors and do not necessarily reflect the views of the organizations or agencies that provided support for the project. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

International Standard Book Number-13: 978-0-309-26083-1
International Standard Book Number-10: 0-309-26083-3

Additional copies of the report are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

Cover: Imaging of glycans in Chinese hamster ovary cells. Glycans are labeled in red and cell nuclei and Golgi apparatus are labeled in blue and green, respectively. Image courtesy of Carolyn Bertozzi, Scott Laughlin, and Jeremy Baskin. Source: Baskin J. M., J. A. Prescher, S. T. Laughlin, N. J. Agard, P. V. Chang, I. A. Miller, A. Lo, J. A. Codelli, and C. R. Bertozzi. 2007. Copper-free click chemistry for dynamic in vivo imaging. Proceedings of the National Academy of Sciences of the United States of America 104(43):16793-16797.

Copyright 2012 by the National Academy of Sciences. All rights reserved.

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