TABLE 1 Summary of Proposed AEGL Values for Five Aliphatic Nitriles Reviewed by the Committee


Classification 10 min 30 min 1 h 4 h 8 h End Point, Derivation Factors

Acetonitrile

AEGL-1 (nondisabling) 13 ppm (22 mg/m3) 13 ppm (22 mg/m3) 13 ppm (22 mg/m3) 13 ppm (22 mg/m3) Not recommended Slight chest tightness and cooling sensation in lung (1 of 3 human volunteers at 40 ppm); MF = 3
AEGL-2 (disabling) 80 ppm (130 mg/m3) 80 ppm (130 mg/m3) 50 ppm (84 mg/m3) 21 ppm (35 mg/m3) 14 ppm (24 mg/m3) One third of AEGL-3 values
AEGL-3 (lethality) 240 ppm (400 mg/m3) 240 ppm (400 mg/m3) 150 ppm (250 mg/m3) 64 ppm (110 mg/m3) 42 ppm (71 mg/m3) No-effect level for maternal and fetal lethality in rats (1,500 ppm, 6 h); UF = 30; n = 1.6 for time scaling

Isobutyronitrile

AEGL-1 (nondisabling) Not recommended Not recommended Not recommended Not recommended Not recommended Insufficient data
AEGL-2 (disabling) 2.5 ppm (7.1 mg/m3) 2.5 ppm (7.1 mg/m3) 2.0 ppm (5.7 mg/m3) 1.3 ppm (3.7 mg/m3) 0.83 ppm (2.3 mg/m3) One third of AEGL-3 values
AEGL-3 (lethal) 7.6 ppm (22 mg/m3) 7.6 ppm (22 mg/m3) 6.1 ppm (17 mg/m3) 3.8 ppm (11 mg/m3) 2.5 ppm (7.1 mg/m3) No-effect level for maternal lethality (100 ppm, 6 h); UF = 30; default time scaling

Propionitrile

AEGL-1 (nondisabling) Not recommended Not recommended Not recommended Not recommended Not recommended Insufficient data
AEGL-2 (disabling) 3.7 ppm (8.3 mg/m3) 3.7 ppm (8.3 mg/m3) 3.0 ppm (6.8 mg/m3) 1.9 ppm (4.3 mg/m3) 1.3 ppm (2.9 mg/m3) One third of AEGL-3 values
AEGL-3 (lethal) 11 ppm (25 mg/m3) 11 ppm (25 mg/m3) 9.1 ppm (20 mg/m3) 5.7 ppm (13 mg/m3) 3.8 ppm (8.6 mg/m3) No-effect level for maternal and fetal mortality (50 ppm, 6 h); UF = 30); default time scaling

Chloroacetonitrile

AEGL-1 Not Not Not Not Not Insufficient data
(nondisabling) recommended recommended recommended recommended recommended  
AEGL-2 (disabling) 8.0 ppm (25 mg/m3) 8.0 ppm (25 mg/m3) 5.0 ppm (15 mg/m3) 2.1 ppm (6.5 mg/m3) 1.4 ppm (4.3 mg/m3) Derived by analogy to AEGL-2 values for acetonitrile
AEGL-3 24 ppm 24 ppm 15 ppm 6.4 ppm 4.2 ppm Derived by analogy to
(lethal) (74 mg/m3) (74 mg/m3) (46 mg/m3) (20 mg/m3) (13 mg/m3) AEGL-3 values for acetonitrile

Malononitrile

AEGL-1 (nondisabling) Not recommended Not recommended Not recommended Not recommended Not recommended Insufficient data
AEGL-2 (disabling) 1.2 ppm (3.3 mg/m3) 1.2 ppm (3.3 mg/m3) 0.77 ppm (2.1 mg/m3) 0.32 ppm (0.87 mg/m3) 0.22 ppm (0.59 mg/m3) Derived by analogy to AEGL-2 values for acetonitrile
AEGL-3 (lethal) 3.7 ppm (10 mg/m3) 3.7 ppm (10 mg/m3) 2.3 ppm (6.2 mg/m3) 0.98 ppm (2.7 mg/m3) 0.65 ppm (1.7 mg/m3) Derived by analogy to AEGL-3 values acetonitrile

Accordingly, emphasis on fetal death should be reflected in the summary table on page II-35, Appendix II-B, where detailed data were given for maternal death but not fetal resorption/nonsurviving implants.



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