D

SUMMARY OF FEDERALLY FUNDED RESEARCH RELATED TO OEF AND OIF POPULATIONS

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Table D.1 lists federally funded research related to Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) populations, including completed studies, ongoing studies, and studies that had missing or incomplete information such that the committee was unable to determine their status. The table is incomplete due to the difficulty in finding some of the information; however, it provides the reader with an idea of the breadth of the numerous studies that are being conducted and/or funded by the U.S. government.



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D SUMMARY OF FEDERALLY FUNDED RESEARCH RELATED TO OEF AND OIF POPULATIONS Table D.1 lists federally funded research related to Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) populations, including completed studies, ongoing studies, and studies that had missing or incomplete information such that the committee was unable to determine their status. The table is incomplete due to the difficulty in finding some of the information; however, it provides the reader with an idea of the breadth of the numerous studies that are being conducted and/or funded by the U.S. government. D-1

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D-2 TABLE D.1 Summary of Federally Funded Research Related to OEF and OIF Populations Principal End Date Title Study Population and Methods Investigator/Sponsor Completed Studies 2008-04 Evaluation of Two Telehealth The study targeted newly returned veterans from the Iraq and Afghanistan Barbara L. Niles Interventions Targeting Post- conflicts. Specifically, researchers compared the relative efficacy of an alternative (principal Trauma Stress in Combat therapeutic approach, a mindfulness-based treatment, with a psychoeducation investigator)/VA Veterans: Comparing treatment in reducing symptoms of posttraumatic stress disorder (PTSD) and more Mindfulness and Psychoeducation generalized psychiatric symptoms, while increasing quality of life. Of note, both treatment conditions consisted of two in-person sessions and six brief, weekly telephone calls. Participants were 58 veterans (29 per condition) recruited from the Department of Veterans Affairs (VA) Boston Healthcare System. Assessment occurred before and after the delivery of the intervention. It was hypothesized that while both treatments will result in improved outcomes the mindfulness intervention will promote more healing than the psychoeducation intervention (Final N = 33). 2008-09 Tracking OEF/OIF Transition The primary objectives of the study were to establish the feasibility of Department Laurel Anne from DOD to VA of Defense (DOD)-to-VA protected health information transfer on a local level, and Copeland, VA South to assess the rate of transition to VA from Brooke Army Medical Center (BAMC) Texas Health Care for the cohort of BAMC patients seen during fiscal year (FY) 2002–FY2007. System/VA Cohort included 994 OEF/OIF seriously wounded warriors cared for at and discharged from BAMC during FY2002–FY2006. 2009-03 Evaluation of Polytrauma Brain Objectives of this 6-month evaluation using multimethods were to (1) identify Steven G. Scott, Injury Rehabilitation Transitional learning needs (skills, knowledge, attitudes) of providers in the transitional James A. Haley Program program at one VA Medical Center (VAMC) as perceived by staff as well as Veterans patients and family members; (2) determine the content and processes of an Hospital/VA educational program to meet the needs of providers; and (3) determine feasibility, test burden, and content validity of a battery of outcome measures for patients and families. 2009-04 Treatment of Insomnia in Military A 4-week behavioral treatment that targets chronic insomnia (lasting >1 month) Anne Germain, Veterans: Phase 1 was tested in 12 service members returning from OEF/OIF. University of Pittsburgh 2009-05 Rural/Urban Differences in Data from the OEF/OIF registry and the Veterans Integrated Service Network Teresa J. Hudson, Service Utilization Among (VISN) 16 data warehouse were used to identify OEF/OIF veterans (n = 32,164) PharmD Central OIF/OEF Veterans who were enrolled in VISN 16 since September 11, 2001. Demographic, service Arkansas VHS, use, alcohol use disorders, depression and PTSD screening, and pharmacy records Eugene J. Towbin were extracted for the 6 months following the index dates for VA first encounter. Healthcare Center/VA

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2009-05 Assessment of the Health Care The National Survey of Women’s Veterans (NSWV) is a nationwide telephone Donna L. Needs and Barriers to VA Use survey of women veterans, including both VA users and VA nonusers, with Washington, VA Experienced by Women oversampling of OIF/OEF veterans. Survey items included measures of Greater Los Angeles demographic and military service characteristics, health status, VA- and non-VA Healthcare ambulatory care use, and determinants of and barriers to VA health care use (N = System/VA ?). 2009-06 Team Based Initiative Support This study investigated family needs of six rural families caring for a veteran with Linda Olivia (pilot study) traumatic brain injury (TBI) 1 to 5 years post-injury. Unmet needs were indentified, Nichols, Memphis, training about TBI and a resource book with information on TBI diagnosis, TN/VA prognosis, and symptoms provided to families. 2009-07 Forgiveness-Based Writing to A forgiveness-based writing intervention was evaluated in 20 OEF/OIF veterans Catherine R. Prevent PTSD in OEF/OIF who recently experienced combat-related trauma. Barber/South Veterans Central VA 2009-08 Visual Dysfunction in MTBI: A In this study, 75 patients diagnosed with PTSD but with no history of mild Gregory Goodrich, Comparison Group Study traumatic brain injury (mTBI) completed a visual screen (assessments of visual VA Palo Alto acuity, visual field, self-reported visual function, and measures of accommodative Health Care function, vergence, pursuit, and saccades). The results were compared to data from System/VA the ongoing study of visual dysfunction in patients diagnosed with mTBI. 2009-08 The Use of Anti-Oxidants to This study compared the effectiveness of the observation and administration of N- Michael E. Reduce Sequela of Mild TBI acetyl-cysteine (7 days) to placebo in 150 individuals with mTBI on hearing and Hoffer/Brooke (mTBI) After Blast Exposure balance function. Army Medical Center 2009-09 Motivational Interviewing to In this study, a randomized controlled trial of 1,000 OEF/OIF veterans was used to Karen H. Seal/San Engage OEF/OIF Veterans in evaluate the efficacy of telephone-administered motivational interviewing Francisco VA Mental Health Treatment compared to informational support sessions. 2009-09 Telephone Based Care for In this study, 20 patients with a clinical diagnosis of PTSD were followed by a case Bradford L. Felker, OIF/OEF Veterans With PTSD manager for up to 6 months to evaluate the feasibility of augmenting standard Puget Sound VA PTSD treatment with Translating Initiatives for Depression into Effective Solutions Health Care (TIDES)-based telephone-based nurse-care management. System/VA 2009-09 Impact of Practice Structure on This study examined changes in how VA women’s health care was organized over Elizabeth M. Yano, Quality of Care for Women time, conducting analyses of VA women’s health organizational surveys VA Greater Los Veterans (Phase 2) administered in 2001 and 2006–2007 to the census of VAMCs and large Angeles Health Care community-based outpatient clinics (CBOCs) that served 300 or more women System/VA veterans, based on prior year. D-3

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D-4 Principal End Date Title Study Population and Methods Investigator/Sponsor 2009-10 The Efficacy of Virtual Reality In this study, 136 service members with PTSD related to service in Iraq or Brenda (VR) as an Adjunct Therapy for Afghanistan were randomly assigned to receive either the virtual reality treatment Wiederhold/Office Acute Combat-Related Post- or usual treatment. of Naval Research, Traumatic Stress Disorder Virtual Reality (PTSD) in Non-Combatants Medical Center 2009-10 Dissemination Evaluation of A postdeployment education materials booklet was disseminated to 3,400 veterans Constance R. Educational Materials for Puerto and family members at the “Welcome Home” event in San Juan, Puerto Rico. Uphold, North Rican OIF/OEF Veterans and Partners, champions, and other providers disseminated 10,326 additional booklets Florida/South Families to Puerto Rican veterans and family members. The webpage on the VA Caribbean Georgia Veterans Health Care was accessed 263 times. Health System/VA 2009-10 Implementation and Researchers designed and conducted semistructured telephone interviews of a Elizabeth M. Yano, Sustainability of VA Women’s national sample of clinic directors of special women veterans’ mental health VA Greater Los Mental Health Clinics programs (n = 35 VA mental health clinicians and administrators); interviewed a Angeles HCS/VA small pilot sample (n = 9) of women veterans based at the VA Greater Los Angeles Healthcare System to explore their needs, preferences, utilization, and experiences in seeking and obtaining VA mental health care services; conducted two focus groups of OEF/OIF women veterans (VA users and nonusers). 2009-11 Testing the Use of Interoceptive In this study, 40 male OEF/OIF veterans with combat-related PTSD randomized to Kevin S. Del Exposure to Reduce Barriers to either receive 4 weeks of supportive counseling or interoceptive exposure to test Ben/G.V. (Sonny) Psychotherapy anxiety sensitivity and avoidance. Assessments were conducted prior to and 5 to 6 Montgomery VA weeks after therapy. Medical Center 2009-12 Prazosin vs Paroxetine in Combat This study involved a placebo-controlled 12-week clinical trial of prazosin versus Elaine Peskind, VA Stress Symptoms in OIF/OEF paroxetine in 210 OEF/OIF veterans to evaluate efficacy and tolerability of Puget Sound Health Returnees prazosin. The study assessed trauma-related nightmares, sleep disturbance, and Care System, change in global clinical status at baseline, 6, and 12 weeks. Seattle/VA 2009-12 Implementing Integrated Care for The objective of this study was to assess the organization and degree of integrated Amy M. Kilbourne, Veterans with Serious Mental care for substance use and general medical services in Veterans Health VA Ann Arbor Illness Administration (VHA) mental health programs and to evaluate the association Healthcare between underlying organizational characteristics (e.g., staffing, information System/VA technology, performance incentives), degree of clinical integration (e.g., coordination, comprehensiveness, and continuity of care), and patient-level outcomes (e.g., quality of care).

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2009-12 Effects of Performance The aim of this study was to develop an in-depth understanding of positive and Adam A. Powell, Measurement on Healthcare negative unintended effects of primary care clinical performance measurement on VA Medical Center, Systems care delivery processes, on health care providers, and on patients. Researchers Minneapolis/VA conducted semistructured in-person individual interviews of staff members at four VA facilities between February and July 2009. A total of 60 interviews were conducted, including 44 with primary care staff and 16 interviews with facility administrators. 2010-04 Process Quality Measures of The objectives of this study were to determine the degree of association between Alex H.S. Harris, Addiction Care: Validation and meeting the process of care criteria at the patient level with outcome quality VA Palo Alto Refinement measures; determine the degree of association between facility-level rates of Health Care meeting the process of care measures with outcome quality measures (e.g., average System/VA patient outcomes), structural quality measures (e.g., number of substance use disorders (SUD) beds, patient-to-staff ratios), and other process measures (e.g., adherence to clinical practice guidelines). Researchers examined three preexisting samples of VA SUD patients (n = 5,723; 3,450; and 340,000, respectively) and evaluated the degree of association between the three process-of-care quality measures and outcome quality measures (e.g., SUD symptom and psychosocial improvement) and structural quality measures. 2010-04 VA’s Quality Transformation: The purpose of the study was to integrate and analyze a series of highly unique data Elizabeth M. Yano, Lessons for Evidence-Based sources that span VA’s reorganization launched in 1996 with Kizer’s Vision and VA Greater Los Management Journey for Change policy documents, starting from a pre-directive year (1993), Angeles HCS/VA through early (1996) and later reorganization (1999–2000). The objective was, therefore, to evaluate organizational and contextual determinants that contributed to VA’s quality transformation. 2010-05 Benzodiazepine Receptor in This project examined binding of the benzodiazepine receptor in Iraq combat James Douglas, PTSD veterans with and without PTSD and to see if it can predict which returning Emory University veterans will develop chronic PTSD. Bremner/National Institute of Mental Health (NIMH) 2010-05 The Effect of EFT (Emotional In this study, those with a PTSD-positive assessment on the PTSD Checklist- Dawson Freedom Techniques) on Military (PCL-M) were randomized into two groups. Control group continued to Church/Soul Psychological States in a receive standard of care (SOC) from providers. Experimental group received SOC Medicine Institute Veterans Population: A plus emotional freedom techniques coaching. Assessments were made after 6 Randomized Controlled Trial completed sessions and after 3 and 6 months (N = ?). D-5

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D-6 Principal End Date Title Study Population and Methods Investigator/Sponsor 2010-06 Improving Quality-of-Life and This pilot study of potential benefit, feasibility, and safety of the Vets Prevail Benjamin Depressive Symptoms for Program Intervention consisted of a single group (pre-/post-comparison) of 50 VanVoorhees, Rise OEF/OIF Combat Veterans: recent OEF/OIF veterans in the frame work of a phase 1 clinical trial (phase 1). Consulting, Assessing the Benefits of Feasibility (adherence and satisfaction), evidence of clinical benefit, would be LLC/Prevail Health Interactive, Internet-based evaluated through changes in the following clinical self-report measures: (1) Solutions, LLC Psychotherapy and Peer-to-Peer symptoms of depressed mood (Center for Epidemiologic Studies Depression Support Scale), (2) PTSD (PCL-M), and (3) functional status (Short Form 12), as well as changes in key attitudes toward mental health care seeking (intent to seek treatment, mental health self-efficacy, and stigma). 2010-06 Participation in PTSD: Who This pilot study sampled over a 1-year period veterans with no non–substance Michele R. Spoont, Starts, Who Stays and Who Drops abuse mental health–related visits in the prior year who received a PTSD diagnosis PhD, Minneapolis Out (n = 20,284). Objectives were to (1) fill the gap in the PTSD treatment evidence VA Health Care base by ascertaining rates and extent of treatment participation among veterans for System, whom PTSD was recently identified as a problem; (2) identify patient, treatment, Minneapolis, and contextual factors associated with treatment dropout or lack of followup in the MN/VA 6 months following receipt of a PTSD diagnosis; and (3) identify specific targets in the PTSD treatment pathway amenable to intervention. 2010-07 Exposure Therapy for Chronic In this study, 36 OEF/OIF veterans with chronic PTSD of at least 3 months Sheila Rauch, Ann PTSD: Efficacy and Mechanisms duration were randomly assigned to 15 sessions of either prolonged exposure (PE) Arbor Healthcare therapy or present-centered therapy. System/VA 2010-07 Randomized Trial of a Self- This study was a randomized trial Internet-based intervention aimed at reducing Juesta M. Caddell, Management Early Intervention PTSD symptomatology and associated functional impairment among combat- RTI/NIMH for Combat-Related PTSD exposed soldiers. The intervention was designed to be both efficacious in reducing PTSD symptomatology and attractive to soldiers returning from combat who are experiencing PTSD symptoms but fear seeking formal mental health treatment because of the stigma and the perceived negative career impact (N = ?). 2010-08 Development of a Family-Based, This pilot study assessed the feasibility and acceptability of the Family Intervention Ivan W. Miller, Post-Deployment Intervention Telephone Tracking-Deployment Readjustment intervention in returning military Butler personnel and their partners (N = ?). Hospital/NIMH

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2010-08 MST Effects on PTSD and Health In this study, relationships between military sexual trauma (MST) and respondents’ Jillian C. Shipherd, Behavior: A Longitudinal Study functioning approximately 11 years after joining the Marines were evaluated VA Boston of Marines utilizing a sample of 1,847 Marine recruits as part of a prospective longitudinal Healthcare study. The objectives were to (1) identify premilitary risk factors for MST; (2) System/VA evaluate MST impact on mental health, health risk behaviors, and functional health outcomes; (3) examine PTSD severity as a mediator of MST and health risk behaviors, and between MST and functional health outcomes; (4) identify risk and resilience factors that moderate the impact of MST on health outcomes; and (5) identify risk factors for suicide. This study is the fifth wave of data collection (T5) in a longitudinal investigation of 1,847 Marines. T5 occurred approximately 10 years after recruit training. 2010-08 Imagery Rescripting for In this study, 7 veterans with combat nightmares and PTSD tested a technique that Mary E. Long, (ter- Posttraumatic Nightmares in teaches specific skills to help improve their sleep habits and decrease the frequency DeBakey minated) Rural Operation Enduring and severity of their nightmares, decrease symptoms of depression and PTSD, and VAMC/VA Freedom (OEF)/Operation Iraqi improve sleep quality and quantity. Freedom (OIF) Veterans With Posttraumatic Stress Disorder (PTSD) 2010-09 Efficacy of Mantram Repetition This study was a randomized, controlled clinical trial to compare a mantram group Jill E. Bormann, VA on PTSD Symptoms in Veterans intervention (6 weeks, 90 minutes per week in small groups) to a delayed treatment San Diego Health control group on outcomes of self-reported PTSD symptoms, psychological Care System/VA distress, and quality of life (N = 146). 2010-09 Evaluation of Family Outreach No additional information found. Heather Reisinger, Mental Health Programs for Iowa City OEF/OIF Veterans VAMC/VA 2010-09 Pilot Test of Preference-Based The specific aims of the pilot test were to evaluate the feasibility of implementing Dana R. Epstein, Insomnia Treatment for OEF/OIF preference-based insomnia treatment and examine its preliminary effectiveness in Phoenix VA Health Veterans improving self-reported insomnia and daytime functioning. Twenty-six veterans Care System/VA participated in a one-group prepost design pilot intervention study. 2010-09 Placebo-Controlled Study of In this study, 100 OEF/OIF veterans with PTSD were randomized to either Lori Lynne Davis, Mirtazapine for PTSD in mirtazapine or placebo to study efficacy and tolerance to the drug. Tuscaloosa OIF/OEF Veterans VAMC/VA 2010-09 Supported Education for OI/EF A Participatory Action Research approach was utilized via assembling a Marsha Langer Veterans with Disabilities development team. The development team was tasked with conducting a needs Ellison, Edith assessment and an implementation assessment for supported education. Data was Nourse Rogers collected through focus groups with OIF/OEF veterans with self-reported Memorial Veterans symptoms of PTSD. Researchers prepared a supported education practice Hospital/VA D-7 curriculum and implementation guidelines based on data collected (N = ?).

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D-8 Principal End Date Title Study Population and Methods Investigator/Sponsor 2010-09 Physical and Sexual Assault in Phase 1 of this study used focus groups to refine the study interview, pilot the Anne G. Sadler, VA Deployed Women: Risks, interview protocol, and ascertain its psychometric properties. Phase 2 involved the Medical Center, Outcomes and Services identification and successful interviewing of 500 women, using random sampling Iowa City/VA with stratification. The telephone interview was used to assess sociodemographic variables, trauma exposures, health history, current health status, military environmental factors (organizational and situational factors), military and VA health care and barriers to this care, and self-reported service use. 2010-09 Outpatient Waiting Times, This project explained the variation within the VA in how long veterans wait for Steven Daniel Pizer, Outcomes, and Cost for VA outpatient care with supply and demand characteristics and examined the potential VA Medical Center, Patients with Diabetes effects of waiting for outpatient care on health outcomes and health care cost. This Jamaica Plain research used VA administrative data and other publicly available Medicare and Campus/VA Medicaid data from the Centers for Medicare and Medicaid Services. 2010-09 Predicting Post-Deployment The goal of this study was to understand risk and resilience factors that predict Susan V. Eisen, Mental Health Substance Abuse development of a psychiatric or substance-abuse disorder and associated mental Edith Nourse and Services Needs health and/or substance-abuse service use. A national, stratified random sample of Rogers Memorial 1,300 veterans enrolled for VA care served as the study sample. Veterans Hospital/VA 2010-09 Treatment of OEF/OIF Veteran Website intervention was developed for OEF/OIF veterans and their families to Armando J. Neuropsychiatric Outcomes treat veteran and family stresses from neuropsychiatric/behavioral consequences of Rotondi, VA Following TBI complicated mild TBI (cm-TBI). The feasibility and acceptability of the websites Pittsburgh Health was tested via a random controlled trial, which enrolls 25 cm-TBI veterans Care System/VA assigned in a 2 (treatment as usual [TAU], n = 10):3 (intervention, n = 15) ratio. 2010-09 Measuring and Improving This research project was designed to examine the issue of sustainability as it Dean D. Krahn, Sustainability in Mental Health relates to the VA Mental Health Systems Redesign (MHSR) initiative. The project MD, William S. System Redesign had three specific objectives: (1) Describe the array of systems redesign projects Middleton Memorial and their outcome measures that had been started in the first phase of the MHSR Veterans Hospital, project. (2) Use the 10-item British National Health Service Sustainability Index to Madison/VA (a) describe the variability in sustainability factors across VISNs and facilities; (b) describe the predictors of sustainability index scores for the various projects; and (c) predict outcome measures and their sustainability for individual projects. The model posits that sustained change is related to ten metrics that can be group as process, organization, and staff factors, which are included in the sustainability index. (3) Interview a random sample of systems redesign team members, including VISN 2 and 12 leadership, facility-level leadership, and clinical and administrative staff, to better understand the factors that facilitate and impede change and sustainability.

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2010-09 CSP 575—PTSD Genomewide The PATRIOT research project was designed to identify possible genetic variations Murray B. Stein and Association Study of OEF/OIF that may influence risk for combat stress reactions. The study was completed in Joel Gelernter/VA Deployed Military Personnel: two stages: (1) feasibility study to test out the study process and (2) use the results Phase I (Feasibility Study) from the feasibility study as a guide for the structure of the second study. The second part of the study will aim to identify genes that may contribute or protect against PTSD (N = 20,000). 2010-10 Advanced MRI in Blast-Related The purpose of this study was to examine the usefulness of magnetic resonance David L. TBI imaging (MRI) scans in predicting memory loss, attention deficit, depression, or Brody/Washington PTSD in 100 active-duty military personnel serving in Iraq or Afghanistan with University School of TBI and other injury control 6 to 12 months postinjury. Medicine 2010-10 Online Interventions for Female Phase 1 of this study identified a random sample of 137 OEF/OIF Reserve/National Anne G. Sadler, VA OEF/OIF Reserve/National Guard Guard (R/NG) service women from a five-state Midwest area who returned from Medical Center, War Vets deployment in Iraq or Afghanistan in the prior 12 months. Phase 2 involved 37 Iowa City/VA follow-up telephone interviews with a trained coordinator who also provided information about VHA resources and facilitated access to care as indicated. The long-term goal was to improve R/NG servicewomen’s knowledge about their own postdeployment adjustment and improve their willingness to access VA mental health care. 2010-10 Innovative Practices for This study identified and evaluated the effectiveness of DOD-sponsored programs Robin Weinick, Psychological Health and TBI designed to support psychological health and TBI among service personnel and RAND their families. Corporation/DOD 2010-12 Treatment of Moderate to Mild In this study, 50 OIF/OEF individuals with chronic mild to moderate TBI were Robert S. Cognitive Dysfunction Caused by assigned to an intervention (100% oxygen at 2.4 ATA in three 30-minute periods Michaelson/San Traumatic Brain Injury (TBI) separated by 10 minutes of breathing air at 2.4 ATA; ATA = atmosphere absolute) Antonio Military With Hyperbaric Oxygen Therapy or sham arm. Assessments (computer based cognitive tests) conducted pre- Medical Center (HBOT) exposure, after 15 HBOT, and 6 weeks post-HBOT. 2010-12 Combined Exposure Therapy and In this study, 40 participants with 9/11-related or Iraq War–related PTSD were JoAnn Difede/Weill D-Cycloserine vs Placebo for assigned to one of two programs—both included Virtual Reality Exposure Therapy Medical College of Posttraumatic Stress Disorder and standard cognitive-behavioral therapy techniques. One group received Cornell University cycloserine (seromycin), and one group received a placebo. 2010-12 PTSD Symptom Reduction by In this study, 76 OEF/OIF veterans meeting Diagnostic and Statistical Manual of Scott P. Orr, VA (ter- Propranolol Given After Memory Mental Disorders, 4th Edition (DSM-IV) criteria for chronic PTSD were randomly Medical Center, minated) Activation assigned to the propranolol or placebo drug condition. Six memory reactivation Manchester/VA sessions were immediately followed by administration of propranolol or placebo. Assessments were conducted immediately after and 6 months after the treatment sessions. D-9

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D-10 Principal End Date Title Study Population and Methods Investigator/Sponsor 2010-12 Blast-Related Health Problem This 2-year population-based study characterized the OEF/OIF experiences with Steven G. Scott, Identification and Polytrauma polytrauma and blast-related injuries (PT/BRI) among the 10,000 current members James A. Haley Taxonomy of the Florida National Guard. The purpose of project was to be able to modify the Veterans natural history of these blast-related injuries, minimizing the adverse sequelae and Hospital/VA maximizing recovery. 2010-12 Identifying Potential Demand for The objective of this research was to improve access to rehabilitation services for W. Bruce Vogel, VA Rehabilitation Services for OEF/OIF veterans with spinal cord injury (SCI), TBI, and amputations. North Florida/South OEF/OIF Veterans Researchers identified those geographic areas and their injured OEF/OIF veteran Georgia Veterans cohorts that have the greatest potential demand for VHA rehabilitation services. Health System/VA Researchers used Geographic Information System tools previously applied to both the VHA TBI population and, more recently, to the FY2003 and FY2004 OEF/OIF traumatically injured veterans who used VHA services. 2011-00 A Needs Assessment of The objective of this project is to assess the physical health, mental health, and Terry Schell, RAND Returning Veterans and their social service needs of veterans and their family members residing in New York Corporation Families in NY State State. 2011-01 Risperidone Treatment for In this study, 400 veterans with the diagnosis of military-related PTSD were John H. Krystal, VA Military Service Related Chronic enrolled at 20 VAMC hospitals over a 2-year period. Patients were randomized in a Connecticut Health Post-Traumatic Stress Disorder double-blind manner to risperidone or placebo. Comparison between groups were Care System/VA made at 6 months. 2011-01 Effects of Escitalopram on In this study, researchers studied if taking escitalopram normalized heart rate Sriram Autonomic Reactivity in Post variability and decreased (or no effect implying a lack of serious cardiac side Ramaswamy, VA Traumatic Stress Disorder Among effects), including QT variability in veterans with PTSD. Primary outcome Nebraska Western Veterans of Operation Enduring measures were to (1) investigate the effects of escitalopram on cardiac vagal Iowa Health Care Freedom and Iraqi Freedom function as measured by R-R interval variability, especially in the high-frequency System/VA (OEF/OIF) (0.15–0.5 Hz) band in OEF/OIF veterans with PTSD [time frame: 12 weeks; designated as safety issue: Yes]; and (2) investigate the effects of escitalopram on an absolute or relative decrease in cardiac sympathetic function and serious cardiac side effects as measured by QT interval variability in OEF/OIF veterans with PTSD (N = 30). 2011-02 Applying Rapid Assessment In this study, participants were recruited from key stakeholder groups within the Patrick E. Link, VA Process to Health Outreach to 22nd VISN geographic area: (1) OEF/OIF veterans; (2) OEF/OIF veteran’s social Greater Los Angeles OIF/OEF Veterans contacts important to their health care seeking; and (3) outreach, policy, and Healthcare administrative personnel from the VA. Semistructured interviews were performed System/VA with outreach staff, policy and administrative personnel, and veteran’s social contacts. OEF/OIF veterans were to participate in focus groups and complete a short survey (N = ?).

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2011-03 Early Intervention for PTSD in In this study, 160 OIF veterans who returned from Iraq in the past 6 months and Doug Bremner, (with- Iraqi Veterans who meet criteria for early PTSD were randomized to receive either paroxetine or Atlanta VA Medical drawn) placebo. PTSD symptoms, brain markers, neuropsychological testing of memory, and Rehab Center, and cortisol response to an Iraq-related traumatic script before and after the Decatur/VA intervention were assessed. 2011-03 Evaluation of TBI Screening The aims of this study were to examine factors associated with receipt of the TBI Bridget Smith, Processes and Healthcare clinical reminder (CR) and the association between the results of the TBI CR, Edward Hines, Jr. Utilization veteran characteristics, and subsequent VA health care utilization and costs. VA Hospital/VA 2011-03 Identifying Patterns of BMI The objective of this pilot proposal was to identify patterns of body mass index Patricia Hirt Change in OEF/OIF Veterans (BMI) change in veterans returning from Afghanistan (OEF) and from Iraq (OIF). Rosenberger, VA Researchers created and analyzed a longitudinal database using VA electronic Connecticut record data (N = 16,656). Healthcare System West Haven Campus/VA 2011-03 Mission Reconnect: Promoting In this study, 40 veterans and their chosen partners participated in focus groups and William B. Resilience and Re-Integration of workshops and to test prototype materials with the overall goal of producing a Collinge, Collinge Post-Deployment Vet multimedia educational intervention that will support OEF/OIF veterans and their and partners with instruction in cognitive and behavioral processes at home. Associates/NIMH 2011-03 Perspectives on Enhancing This study involved approximately 160 participants (80 veterans and 80 family Ellen P. Fischer, Family Involvement in Treatment members). Researchers used qualitative methods to identify the needs and Central Arkansas for PTSD preferences of OIF/OEF veterans and family members and assessed the VHS Eugene J. implications of study findings for program design. Researchers conducted Towbin Healthcare individual and group interviews in Little Rock and Oklahoma City with 40 male Center/VA veterans. Researchers conducted separate individual and group interviews in Little Rock and Oklahoma City with 40 female veterans and with 80 family members of participating veterans in those cities. Interviews addressed perceived needs, desires for family involvement in treatment, types of services that are attractive/unattractive, elements of alternative approaches to meeting needs that are attractive/unattractive, as well as logistic considerations (e.g., timing and frequency of meetings, mode of meeting, child care). Researchers used the techniques of constant comparison and content analysis to analyze interview data (N = 160). 2011-03 Psychophysiological Reactivity to No additional information found. VA Identify and Treat Veterans at Risk for PTSD 2011-03 Treatment of Comorbid Insomnia In this study, 40 OEF/OIF returnees were randomized to either the brief behavioral Anne Germain, in Military Veterans treatment of insomnia intervention or to information control condition. Sleep University of measures, as well as measures of PTSD, anxiety, depression, and perceived Pittsburgh/NIMH D-11 physical health, were measured.

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D-54 Principal End Date Title Study Population and Methods Investigator/Sponsor 2015-04 Neural Correlates of Cognitive The longitudinal research design for this project will be a three factor mixed Brian Rehabilitation in Posttraumatic factorial design with between subject factors of PTSD (+PTSD × –PTSD) and Schweinsburg, VA Stress Disorder cognitive remediation (learning-based cognitive training [LBCT] × nonlearning Connecticut training [NLT]) and the within subject variable of time tested (pretraining, Healthcare System, posttraining, 3-month follow-up). In this study, 40 participants will be enrolled in Yale University/VA four groups of 10 each: (1) +PTSD/LBCT, (2) +PTSD/NLT, (3) –PTSD/LBCT, and (4) –PTSD/NLT. All groups will receive 40 hours of computerized training. Outcomes will be measured at baseline (i.e., pretreatment), after an average of 8 weeks of treatment and at 6 months posttreatment. The active treatment is the Posit Science visual cognitive remediation paradigm (i.e., InSight), while the control treatment will utilize games face valid for cognitive training. This study will examine the effects of a standardized cognitive rehabilitation program on neurocognitive functioning and brain functional activation in OEF/OIF veterans with PTSD (N = 40). 2015-05 Integrated Treatment of OEF/OIF The proposed study will test the feasibility and preliminary efficacy of an Sudie E. Back, Veterans with PTSD and integrative behavioral intervention for the treatment of co-occurring SUDs and Medical University Substance Use Disorders PTSD modified for use among U.S. military personnel (including National Guard of South Carolina/ and reservists) who have served in OEF/OIF. The intervention, called “Concurrent NIDA Treatment with Prolonged Exposure” (COPE), represents a novel treatment that integrates cognitive-behavioral therapy for SUDs with prolonged exposure therapy for PTSD. In this hybrid Stage Ib/Stage II study, researchers will (1) use a manualized, well-tolerated behavioral treatment for SUDs and PTSD (COPE); (2) employ a two-arm randomized between-groups experimental design (COPE versus a modified TAU; and (3) examine standardized, repeated dependent measures of clinical outcomes and process variables at five time points (pre-, mid-, and post- treatment and 3- and 6-month follow-up).

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2015-05 Predicting Treatment Response The specific aims of the study are to (1) evaluate the clinical utility of John Spollen, MD, Using Psychophysiologic psychophysiologic reactivity measures to predict overall PTSD symptom response Central Arkansas Reactivity Measures among OEF/OIF/OND veterans receiving treatment for PTSD and (2) evaluate the Veterans Healthcare clinical utility of psychophysiologic reactivity measures to predict psychosocial System/VA functioning and health-related quality of life response among OEF/OIF/OND veterans in treatment for PTSD. Develop psychophysiologic, neuropsychological, and/or self-report models to predict PTSD symptom response to pharmacotherapy, psychotherapy, and combined pharmacotherapy/psychotherapy. Investigators will divide psychophysiologic reactivity predictors into two groups: heart rate variability and attentional bias (eye gaze tracking and modified Stroop). Investigators will collect observational and longitudinal data from a treatment- seeking sample of 50 OEF/OIF/OND veterans with PTSD recruited from the Central Arkansas Veterans Healthcare System Mental Health Clinics (N = 50). 2015-06 Stress-Induced Drinking in The proposed clinical laboratory project will use a three-group design. The target Ananda B. OEF/OIF Veterans: The Role of OIF/OEF population will have no trauma exposure (control group), combat trauma Amstadter, Medical Combat History and PTSD exposure without PTSD, and combat trauma exposure with PTSD. This project will University of South use a well-established clinical laboratory paradigm of stress induction employed by Carolina/NIAAA the group, the Trier Social Stress Test (TSST), to investigate the role of a history of exposure to combat trauma on reactivity to the TSST and on stress-induced voluntary drinking. First specific aim examines the effect of combat trauma history on stress reactivity, using subjective, neuroendocrine, and physiological measures of stress. The second specific aim will examine the effect of combat trauma history on subsequent drinking behavior and subjective response to alcohol using established procedures in a clinical laboratory paradigm (N = ?). 2015-07 Exposure Therapy for Veterans This study is the first systematic investigation of a time-limited, multicomponent Ellen Teng, Michael with PTSD and Panic Attacks cognitive-behavioral treatment for veterans with specific comorbid anxiety E. DeBakey VAMC/ problems. The purpose of the first phase of the study is to evaluate the feasibility VA and acceptability of the multicomponent cognitive-behavioral treatment in an open trial. The purpose of the second phase of the study is to evaluate the effectiveness of the multicomponent cognitive-behavioral treatment in comparison to standard PTSD treatment in military personnel returning from active duty (N = ?). D-55

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D-56 Principal End Date Title Study Population and Methods Investigator/Sponsor 2015-08 Veteran Reintegration, Mental The specific aims of the project are as follows: Andrew L. Golub, Health and Substance Use in the • Aim A—Substance use. To understand changes over time in substance use National Inner-City (including illegal drugs, psychotherapeutic drugs without a prescription, alcohol, Development and and tobacco), problem use, treatment experiences, and barriers to treatment among Research veterans returning from Afghanistan OEF/OIF to the inner city. Institutes/NIAAA • Aim B—Mental health disorders. To document the path to mental health problems (especially PTSD, consequences of TBI and depression) among OEF/OIF veterans returning to the inner city, as well as factors that promote or impede resilience and effective use of treatment. • Aim C—Civilian reintegration. To identify successful coping strategies that promote healthy, productive reintegration to civilian life in the inner city, as well as personal problems, unproductive behaviors, and social forces that challenge veterans with regard to family, HIV infection/risk, work, and community life. 2015-08 Central Auditory Processing This research team has established that recently blast-exposed soldiers show Frederick Gallun, Deficits Associated with Blast differences from controls on tests of central auditory function. This project will (1) Portland VAMC, Exposure develop a more accurate estimate of the prevalence of central auditory dysfunction Portland, OR/VA among veterans exposed to blasts over the past 10 years, (2) identify the functional outcomes associated with abnormal performance on tests of central processing, and (3) improve understanding of the ways in which blast-exposure resembles and differs from both the normal aging process and non-blast-related TBI in terms of performance on tests of central auditory processing (N = 200). 2015-08 Homeless Solutions in a VA The objectives of this study are to (1) identify organizational facilitators and Stefan G. Kertesz, Environment (H-SOLVE) barriers to implementation of Housing First in a VA context through qualitative VAMC, data collection among four VA facilities that are currently adopting this approach, Birmingham, AL/ in contrast to four VA facilities that are not adopting Housing First; (2) provide a VA manual identifying manipulable service elements for VA facilities seeking to implement Housing First programs with the use of presently available housing vouchers; (3) compare homeless vulnerability indicators (homeless chronicity, homelessness immediately preceding referral, health diagnoses, utilization history) among veterans served through more traditional homeless veteran programs at four VA sites, in contrast to veterans served at four VA sites that have implemented a Housing First approach; and (4) assess whether VA-based Housing First programs achieve results that are superior to conventional programs in regard to housing.

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2015-09 Integrated vs Sequential The investigators hypothesize that veterans in the integrated conditions will show David W. Oslin, Treatment for PTSD and greater reductions in substance abuse and PTSD symptom severity at the end of University of Addiction Among OEF/OIF treatment and at 6- and 9-month follow-ups. The investigators further hypothesize Pennsylvania/VA Veterans that offering veterans PE therapy at the onset of treatment in the integrated condition will leader to greater retention and satisfaction than in the sequential treatment design (N = 200). 2015-09 Improving PTSD Outcomes in This study seeks to examine the efficacy of hydrocortisone administration in the Rachel Yehuda, OIF/OEF Returnees: A augmentation of the therapeutic effects of PE therapy, an empirically tested James J. Peters Randomized Clinical Trial of treatment shown to be effective in the treatment of PTSD. The augmentation builds VAMC/Mount Sinai Hydrocortisone Augmentation of on both the translation of neuroscience findings demonstrating the effects of School of Medicine Prolonged Exposure Therapy glucocorticoids on learning and on empirical clinical findings from other investigators demonstrating beneficial effects of glucocorticoids in reducing traumatic memories in trauma-exposed persons (N = 60). 2015-09 Diagnosing mild TBI in VA and There are three specific aims in the proposed study. The first aim will investigate Mingxiong Huang, Active Duty Military Patients the diagnostic value of the integrated magnetoencephalography (MEG)-diffusion VA San Diego Using MEG and DTI tensor imaging (DTI) approach in VA and active duty patients with mTBI by Healthcare detecting neuronal injuries (locus of the injury as well as affected neuronal System/VA networks) not visible with conventional neuroimaging methods (e.g., computed tomography [CT] and MRI). Preliminary data show that pathological MEG slow- waves, reduced MEG functional connectivity, and reduced DTI anisotropy are characteristics of axonal injury due to tissue shearing and stretching in mTBI, with markedly better sensitivity than CT/MRI in diagnosing individual mild TBI patients. The second aim is to study the neurophysiological basis of the cognitive impairments using N-back working memory MEG task in active-duty and VA patients with mTBI. The third aim will study the relationship between post- concussive symptoms, cognitive deficits as measured by neuropsychological exams, and the neuroimaging measurements with MEG and DTI in VA and active- duty patients with mTBI. To achieve these aims, the study proposes to develop new imaging analysis tools: frequency-domain VESTAL for accurately localizing pathological MEG slow-waves; Dual-core Beamformer for reliably obtaining the neuronal networks with reduced functional connectivity using MEG under the condition of poor signal to noise ratio; and a platform for integrating the functional MEG findings in the gray matter with structural DTI findings in the white-matter fiber tracts (N = ?). 2015-09 Measuring Quality of Life in Abstract is under review as of September 14, 2012. Stephen Lee Luther, Veterans with Deployment- James A. Haley Related PTSD Veterans’ Hospital, D-57 Tampa, FL/VA

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D-58 Principal End Date Title Study Population and Methods Investigator/Sponsor 2015-10 Neural Markers and Although the relationship between combined TBI/PTSD diagnoses and Eric B. Elbogen/ Rehabilitation of Executive postdeployment adjustment problems has been demonstrated, there has been little University of North Functioning in Veterans with TBI research into clinical interventions designed to reduce the severity of cognitive and Carolina, Chapel and PTSD affective symptoms in veterans with both TBI and PTSD. Therefore, the Hill investigators propose a randomized clinical trial involving a cognitive rehabilitation intervention that targets improved executive functioning, with the participation of n = 100 veterans diagnosed with both TBI and PTSD (n = 50 in experimental group and n = 50 comparison). 2015-10 Brain Training to Enhance This study is being done to improve the ability to diagnose and to achieve higher Daniel Krawczyk/ Frontal Lobe Reasoning in levels of functional recovery in soldiers and civilians who have suffered either The University of Soldiers and Civilian Adults with mTBIs or moderate-to-severe TBIs at chronic stages of brain recovery (greater than Texas, Dallas, TBI 12 months). This study will examine short-term effects of treatment on cognition University of Texas and real-life outcomes in soldiers and civilians with TBI. Participants will undergo Southwestern neuropsychological testing posttraining (10 weeks) as well as 3 months posttraining Medical Center (N = 100). 2015-10 Brain Training to Enhance This study is being done to improve the ability to diagnose and to achieve higher Daniel Krawczyk/ Frontal Lobe Reasoning in levels of functional recovery in soldiers and civilians who have suffered either University of Texas, Soldiers with TBI mTBIs or moderate-to-severe TBIs at chronic stages of brain recovery (greater than Dallas 12 months) (N = ~100). 2015-12 Randomized Trial of Sertraline, This study aims to compare the effectiveness of two proven treatments for PTSD: Sheila Rauch, VA Prolonged Exposure, and their PE, sertraline, and their combination. In addition, the investigators are examining Ann Arbor Combination for Post-Traumatic predictors of response to these two treatments and how PTSD symptoms, thoughts, Healthcare System/ Stress Disorder (PTSD) in and biological factors may be changed by such treatments. In addition, the VA Operation Enduring investigators will examine acceptability of each treatment and reasons for ending Freedom/Operation Iraqi treatment. PTSD symptoms as measured by the Clinician Administered Freedom (OEF/OIF) Posttraumatic Stress Disorder Scale (N = 441).

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Principal End Date Title Study Population and Methods Investigator/Sponsor 2016-01 Accuracy and Validity of ICD9 The purpose of this study was to examine the validity of three algorithms tested Thad Abrams, MD, Codes for PTSD in Veterans against medical chart evidence for two different types of basic research questions Iowa City VAMC/ (1) which definitions best predict for a diagnosis of PTSD and (2) which definitions VA best predict for the receipt of medication treatment for PTSD. Investigators will use electronically stored medical record data to examine 600 veterans, 300 with PTSD and 300 without any administrative data evidence for PTSD. Charts will be reviewed specifically to determine whether the treating providers’ presented evidence of either the identification of PTSD or treatment for PTSD. Data will be extracted using a structured chart abstraction form and will be done by trained research assistants with formal psychological training. Medical record evidence of the identification of PTSD and/or treatment of PTSD will be gathered and then scored based on a 5-point Likert scale indicating the degree of certainty that PTSD was being actively monitored and/or treated. 2016-03 Improving PTSD Service The aim of this study is to compare the efficacy of PE for PTSD plus TAU Anouk L. Grubaugh, Delivery for Veterans with Severe (PE+TAU) relative to TAU alone using a randomized, between groups, repeated Ralph H. Johnson Mental Illness measures design. In this study 156 ethnically/racially diverse male and female VAMC/VA veterans with PTSD and SMI will be recruited from the Charleston VA and affiliated CBOCs during the study time frame. Veterans will be randomized 1:1 to one of two conditions: PE+TAU or TAU. The active intervention phase is 12 weeks. Veterans randomized to TAU will receive support services through the VA, potentially inclusive of case management, psychotropic medication management, and/or supportive counseling, and veterans randomized to PE plus TAU will receive 12 weekly sessions of PE in addition to TAU. All participants will be assessed at baseline, 6 weeks, posttreatment, and at 3 and 6 months. 2017-04 Neuroimaging and Cognitive This study will address some of these gaps in the literature by evaluating the neural Kathleen Pagulayan, Correlates of Repetitive Blast- underpinnings of persisting cognitive difficulties in veterans with a history of VA Puget Sound Related mTBI repeated blast-related mTBI. Specifically, preliminary research involving OEF/OIF Healthcare System veterans with a history of blast-related mTBI has found evidence of both reduced working memory on neuropsychological measures and cerebellar abnormalities that are visible on neuroimaging. A large-scale brain system that includes both cortical and cerebellar components is involved in verbal working memory, and this Career Development Award will enable the investigation of the functional and structural integrity of that system. Two complementary neuroimaging methodologies (resting state functional connectivity fMRI and diffusion tensor imaging) will be used to investigate the functional connectivity of the cerebral components of this network with the cerebellar components and the integrity of the white matter tracts that physically mediate this connectivity. D-59

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D-60 Principal End Date Title Study Population and Methods Investigator/Sponsor 2020-01 Millennium Cohort Study This study will evaluate the long-term health effects of military service, including Nancy F. Crum- (estimate) deployments. About 150,000 current participants are expected, with low response Cianflone, Naval rates. Health Research Center, San Diego, CA/DOD Awaiting The Soldier’s Life Study No additional information found. Terry L. Schell, ARI (Expansion to Deployment Life RAND Corporation/ approval Study) U.S. Army and Army data for sampling (as of 09/2012) Data Welcome Back Veterans No additional information found. Terri Tanielian and collection Performance Monitoring Center Laurie Martin, and RAND Corporation/ analysis McCormick under way Foundation (as of 09/2012) Data Informing the Department of No additional information found. Rajeev Ramchand, collection Defense Strategy on Prevention RAND Corporation/ and of Suicide by Members of the DOD analysis Armed Forces under way (as of 09/2012) Awaiting Preventing and Managing No additional information found. Rosalie Pacula, IRB Prescription Drug Misuse Among RAND Corporation/ approval Military Personnel DOD (as of 09/2012) Preparing Family Resilience in the Military No additional information found. Sarah Meadows, IRB RAND Corporation/ application DOD (as of 09/2012)

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Principal End Date Title Study Population and Methods Investigator/Sponsor Preparing Framework for Quality No additional information found. Carrie Farmer, IRB Assessments of Department of RAND Corporation/ application Defense Traumatic Brain Injury DOD (as of and Psychological Health 09/2012) Systems of Care Preparing Stigma Reduction Efforts in the No additional information found. Joie Acosta, RAND IRB Department of Defense Corporation/DOD application (as of 09/2012) Preparing Availability and Efficacy of No additional information found. Ryan Brown and IRB Military-Culture Appropriate Grant Marshall, application Psychological Health Treatment RAND Corporation/ (as of for Geographically Distant DOD 09/2012) Service Members and Their Families Preparing Sleep in the Military: An No additional information found. Regina Shih and IRB Evaluation of Military Programs Wendy Troxel, application and Policies RAND Corporation/ (as of DOD 09/2012) Phase I Review of DOD Suicide No additional information found. Rajeev Ramchand, Complete; Prevention Programs RAND Corporation/ Phases II DOD and III expected early 2013 Recruit- Systematic Treatment No additional information found. Lisa Jaycox, RAND ment under Engagement for Posttraumatic Corporation (in way (as of Stress Disorder Using Primary partnership with 09/2012) Care (STEP-UP) RTI International, Uniformed Services University, and the Deployment Health Clinical Center/ Congressionally Directed Medical D-61 Research Program

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D-62 Principal End Date Title Study Population and Methods Investigator/Sponsor Baseline The Deployment Life Study This study is examining how deployment affects the health and well-being of Benjamin Karney recruitment military families over the course of 3 years. The success of military operations and Terri Tanielian, completed depends not only on the preparation of service members, but also on the RAND Corporation/ among preparation of their families—a concept known as family readiness. This study, DOD three which is being conducted by the RAND Corporation, will help researchers learn services, more about the skills and tools that military families need in order to handle the follow-up stresses associated with deployments. waves ongoing (as of 09/2012) Several Innovative Practices to Support No additional information found. Carrie Farmer, reports Psychological Health and Well- RAND Corporation/ available Being DOD on RAND website, several others forth- coming Studies with Missing or Incomplete Information* NA (Award Identification of Abuse and In this study, a random sample of 2,000 military women screened for intimate Jacquelyn C. Amount: Health Consequences for Military partner abuse; 200 cases and 200 controls selected for in-depth interviews and Campbell (Johns $1,134,157) and Civilian Women medical record reviews. The civilian comparison sample of 2,000 women enrolled Hopkins in Kaiser Permanente HMO. Interview data will include a lifetime history of abuse University)/DOD and opinions about domestic violence screening and reporting. (CDMRP) NA (Award Health Status of Military Women A survey will be mailed to active-duty Army, Air Force, and Guard/reserve Robert M. Bray Amount: in the Total Force personnel in all military branches. Data will be combined with comparable data (Research Triangle $1,874,879) from a survey of active-duty Navy and Marine Corps personnel under way by the Institute)/DOD Naval Health Research Center. (CDMRP)

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Principal End Date Title Study Population and Methods Investigator/Sponsor Unknown The Wellbeing of Army The central hypothesis of the proposed research is that individuals in dual-military Ann Huffman, Personnel in Dual-Military marriages are exposed to unique stressors and benefits in the work and family Northern Arizona Marriages domain and that those in dual-military marriages who receive little or no support University from either domain will experience both negative health and lower subjective feelings of well-being. The proposed research will utilize interviews and surveys. Since there is little empirical research examining dual-military marriages, a qualitative research design (interviews) (Phase I) will be used to examine potential relationships between variables. Phase II of the study will consist of survey administrations. Questionnaires will be administered to individuals who are currently in dual-military marriages and those who have previously been in a dual- military marriage. Unknown Identifying Military and Combat- This proposal seeks to extend the current investigation of identifying risk and Julie Wargo-Atkins, Specific Risk Factors for Child resilience factors in children ages 3–7 of military families with a combat-deployed University of Adjustment: Comparing High and parent by (1) surveying civilian families so as to identify those risk and resilience Connecticut, Storrs Low Risk Military Families and factors specific to a military family and (2) surveying military families with a Civilian Families parent deployed in a support/noncombat role so as to identify those risk and resilience factors specific to high-risk deployments. Researchers predict that military families with a high-combat exposure deployed parent will show unique parent and child risk factors in comparison to military families with a low-combat exposure deployed parent and civilian families. Using a similar survey as with this ongoing work with military families, researchers will assess 200 civilian families with children ages 3–7 from the greater Watertown, New York, area. The study will also survey 200 military families from deployed support brigades of Fort Drum, New York. Unknown Post-Traumatic Stress Disorder This study will evaluate the feasibility and efficacy of a treatment delivery method Alan Peterson, In-Home Therapy Clinical Trial that could help overcome these barriers to care and make effective PTSD treatment University of Texas, Award more accessible to underserved military personnel and veterans. It will evaluate one Health Science of the leading treatments for PTSD, a form of counseling known as Cognitive Center at San Processing Therapy, when delivered in service members’ and veterans’ homes, Antonio either through in-person therapist visits or via the technology of telebehavioral health, as compared to standard, face-to-face treatment in a therapist’s office. Unknown Using Complementary and The project utilizes a placebo-controlled, randomized, single-blind design to Theresa Hernandez, Alternative Medicine (CAM) to determine acupressure’s efficacy at improving mental health and stress reactivity in University of Promote Stress Resilience in veterans with co-occurring mTBI and PTSD. Veterans returning from deployment Colorado Boulder/ those with Co-Occurring Mild in Iraq or Afghanistan will be recruited and after informed consults is obtained, unknown funding TBI and PTSD each will be screened for study eligibility, including the presence of mTBI and source comorbid PTSD (N = ?). D-63

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D-64 Principal End Date Title Study Population and Methods Investigator/Sponsor Unknown Structural and Functional Objectives of this study are to evaluate changes in brain function in recent combat Eric M. Neuroimaging Studies of Combat veterans that may be related to PTSD or postconcussive syndrome (N = 260). Wassermann, Veterans National Institute of Neurological Disorders and Stroke (NINDS)/ NINDS Unknown A Clinic-Based Intervention to Abstract is under review as of April 20, 2012. Additional information not found. Steven R. Simon, Promote Veteran Enrollment in BS, MD, VA Boston My HealtheVet Healthcare System Jamaica Plain Campus, Jamaica Plain, MA Unknown Testing and Evaluation of a This study proposes to test and evaluate a group-based, combat-relevant, Laurel Hourani, Predeployment Stress Inoculation predeployment stress inoculation training (PreSTINT) program designed to help RTI/funder Training Program (PreSTINT) deploying personnel better cope with combat-related stressors and reduce the unknown negative behavioral effects of trauma exposure. The PreSTINT program includes an educational component in which two arousal reduction techniques are presented. During a virtual reality simulated mission, soldiers are trained to control excessive arousal levels while focusing on the mission at hand. Their speed and accuracy in responding to threats as well as their ability to focus and maintain attention are assessed. Two phases of study will test and evaluate the effectiveness of the PreSTINT training program. The effectiveness of the PreSTINT program for arousal and attentional control will undergo testing in year 1, and its ability to reduce postdeployment distress will be examined in years 2 and 3. FY 2011 Using Complementary and The proposed project will utilize a placebo-controlled, randomized, single-blind Theresa Hernandez, Award Alternative Medicine (CAM) to design to determine acupressure’s efficacy at improving mental health and stress Institution Amount: Promote Stress Resilience in reactivity in veterans with co-occurring mTBI and PTSD. Veterans returning from Receiving Award: $260,100 those with Co-Occurring Mild deployment in Iraq or Afghanistan will be recruited and after informed consults is University of TBI and PTSD obtained, each will be screened for study eligibility, including the presence of Colorado, Boulder mTBI and comorbid PTSD. Program: DMRDP *The committee was not able to accurately group these studies into the other two categories.