A21-3    Pinecone fish

A21-4    Female anglerfish with attached male

A21-5    Fire shooter squid

A21-6    The life-cycle of the nematode host of the bioluminescent bacterium Photorhabdus luminescens

A22-1    The two-group model of the intestinal microbiota with antibiotic-sensitive and antibiotic-tolerant bacteria

A22-2    Multistability and hysteresis in a simple model of the intestinal microbiota

A22-3    Most probable microbiota states change from bistable scenario to mono-stable coexistence with increasing noise

A22-4    Microbiota resident time in antibiotic-tolerant domination as a function of the: antibiotic action (ε) and social interaction (ψ) parameters

A22-5    Analysis of microbiota response to the antibiotic ciprofloxacin from three subjects using singular value decomposition identifies antibiotic-sensitive and antibiotic-tolerant bacteria

A22-S1  Vectorial field of forces and the phase-plane analysis for bistable conditions

A22-S2  Model nullclines analysis in the absence of noise

A22-S3  Normalized-to-one areas of the basins of attraction, corresponding to sensitives (green curve) and tolerants (red curve), versus the antibiotic-killing y (A) or the social interaction e (B)

A22-S4  Time evolution of the sensitive (green) and tolerant (red) densities obtained by solving the Langevin equations for f = 1.1, y = 0.7, e variable with time (see Panel A) and three different noise regimes

A22-S5  A: most probable bacterial density r change with respect the noise parameter D when the boundary condition are fixed at negative values far enough from the location of the stable states; B: plot of four different stationary distributions

A22-S6  Stationary path connecting the stable points 1 and 2

A22-S7  Plot of the correlation with principal component 2 (PC2) versus correlation with principal component 1 (PC1) for all the phylotypes detected in each subjects (A-C)

A22-S8  Log2 abundance versus samples for all the phylotypes detected in each subject (A-C)

A22-S9  Ordination plot of the time samples based on their first two principal components



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