tice? Is it the models themselves, research expectations, how models are used to make predictions and decisions, or perhaps the level of knowledge about underlying pathophysiology for any given disease? At each step of the therapeutic development pathway, speakers and participants suggested specific areas for improvement, including the validation of targets, the design of experiments, how results are statistically analyzed, and the way in which positive and negative results are reported. Many participants supported increasing cross-sector collaboration, strengthening training programs and improving the reproducibility of research with a goal of improving translational efforts. Finally, several participants pointed to the need to merge new tools, technologies, and techniques with current research methods, including animal models, as a way to accelerate therapeutic development for nervous system diseases and disorders.