Meeting Objectives:

• Discuss key issues that contribute to poor translation of animal models in nervous system disorders.

o Examine case studies that highlight successes and failures in the development and application of animal models.

• Consider strategies to increase the scientific rigor of preclinical efficacy testing.

o Explore the benefits and challenges to developing standardized animal and behavioral models.

o Identify methods to facilitate development of corresponding animal and clinical endpoints.

• Identify methods that would maximize bidirectional translation between basic and clinical research.

• Determine the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

DAY ONE

1:30 p.m. Opening Remarks

RICHARD HODES, Co-Chair

STEVEN PAUL, Co-Chair

SESSION I: EVALUATION OF CURRENT ANIMAL MODELS

Session Objective: Identify critical limitations impacting translation of therapies from animal models to clinical practice. Explore current expectations of animal models to predict therapeutic efficacy. Determine the impact of generalization of animal model capabilities. Examine the role of animal model–derived data in making decisions about moving therapeutics into clinical trials.

1:40 p.m. Overview and Session Objectives

STEVIN ZORN, Session Chair



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