TABLE 3-1
A Snapshot of Data Required for SMART Vaccines 1.0

Parameter Data Available in the Public Domain Data Requiring User Estimation
Demographics

• Life Tablesa

• Standard Life Expectancya

• Health Utility Index 2

• Hourly Wage Rate

Disease Burden

• Incidence

• Case Fatality Rate

Disease Morbidity

• Disutility (Tolls)b

• Disability Weightsb

• Durationb

• Percent of Cases

• Costs (Hospital, Outpatient, Medication)b

Vaccine Characteristics

• Target Populationa

• Coverage

• Effectiveness

• Length of Immunity

• Doses Required per Person

• Herd Immunity

• Time to Adoption

• Cost per Dose

• Administration Cost

• Research and Development Costs

• Licensure Costs

• One-Time (Start-Up) Costs

a Standard data irrespective of the vaccine candidates.
b Requires case-by-case judgment and modification for specific vaccine complications or morbidity.

Data Sourcing and Quality

The data gathered by the committee are by no means the best or the most detailed estimates for each disease. They are neither precise projections nor comprehensive analyses. For example, there are data available on the burden of influenza and on the impact of seasonal influenza vaccines in the United States, but because there are no currently licensed vaccines for group B streptococcus, the only data available from the United States for that disease concern the disease burden, with nothing on the impact of a vaccine if it were licensed; thus, the vaccine information for group B streptococcus is largely hypothetical. In fact, much of the information required for SMART Vaccines, especially the information related to the use of the vaccines in low-income countries, was based on the opinions of the committee members.

A significant concern regarding the committee’s data analysis was the variability and the lack of standardization in surveillance methods. While data may be widely available for certain parameters, the committee thought it important to use only those data that had been collected using standard, comparable methodologies. To ensure the quality of the data, public sources such as peer-reviewed literature, the World Health Orga-



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