tion and made freely available in an open-source environment to all decision makers and developers around the world.

As a strategy relating to this principle, the committee believes that it would be most beneficial if the National Vaccine Program Office of the Department of Health and Human Services identifies a host for SMART Vaccines and its future versions. Moreover, any decision-support system such as SMART Vaccines has no intrinsic value without accurate and relevant data. Consequently, the committee places the highest importance on creation of a data architecture and expanding data collection for use in SMART Vaccines.

A Vision for the Future

Consistent with this guiding principle and strategy, the committee believes that SMART Vaccines will achieve optimal value if the following events occur:

1. SMART Vaccines and its future versions are hosted in an open-source setting on a widely trusted website with a distinct identity and appropriately protected from unwarranted modifications or intrusions.

2. The host organization creates, maintains, funds, and facilitates a community of users to curate and manage further development of SMART Vaccines and supporting data.

3. The community of users includes decision makers involved in research, development, regulation, and implementation of new vaccines as well as developers with expertise in such areas as modeling, epidemiology, demography, software engineering, database management, and visual design.

4. The community of users—independently or in collaboration with the host organization—establishes an advisory group to help plan future versions and facilitate the adoption of SMART Vaccines.

5. The community of users, together with the host and sponsors, develops mechanisms to encourage the development and updating of data for populations at regional, national, and sub-national levels; for the disease burdens these populations confront; for the costs of preventing and treating those diseases in each distinct environment; and for the productivity losses associated with these disease burdens. These data are accessible in a standardized format, shared with other users through the common website that

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