This report describes SMART Vaccines—Strategic Multi-Attribute Ranking Tool for Vaccines—an early-stage prototype software application based on multi-attribute utility theory. This report does not provide a ranking of vaccine priorities. It describes the committee’s modeling strategy and assumptions in order to demonstrate a proof of concept.

The SMART Vaccines software application is intended to serve only as a decision-support tool. Specific decisions about priorities should not be made solely on the basis of SMART Vaccines. The examples that appear in this report are limited to comparing hypothetical vaccines only.

The National Academy of Sciences and the Institute of Medicine do not warrant the completeness of the model, the accuracy of the software in development, or the reliability of any data presented in this report.

September 2013

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