Vaccine Safety Datalink (VSD) Project: to increase knowledge about vaccine adverse events, the Centers for Disease Control and Prevention have formed partnerships with nine large health management organizations (HMOs) to continually evaluate vaccine safety. The project contains data on more than 9 million people. Medical records are monitored for potential adverse events following immunization. The VSD project allows for planned vaccine safety studies as well as timely investigations of hypotheses.1

Varicella: an acute contagious disease, usually occurring in children, caused by the Varicella-zoster virus genus, Varicellovirus, a member of the family Herpesviridae, and marked by a sparse eruption of papules, which become vesicles and then pustules, like that of smallpox although less severe and varying in stages, usually with mild constitutional symptoms; incubation period is about 14-17 days.5


1Centers for Disease Control and Prevention as defined on the following webpage:

2Merriam-Webster Medical Dictionary, a source used by the National Institutes of Health’s Medline Plus website, which is produced by the National Library of Medicine. The citation for the Merriam-Webster Medical Dictionary term is Merriam-Webster Medical Dictionary [Internet]. [Springfield (MA)]: Merriam-Webster, Incorporated; © 2003, and the specific term can be obtained on the following website:

3A.D.A.M. Medical Encyclopedia, a source used by the National Center for Biotechnology Information, a division of the National Library of Medicine at the National Institutes of Health. The citation for the A.D.A.M. Medical Encyclopedia term is A.D.A.M. Medical Encyclopedia [Internet]. [Atlanta (GA)]: A.D.A.M., Inc.; © 2010, and the specific term can be obtained on the following website:

4A Dictionary of Epidemiology, fifth edition, a handbook sponsored by the International Epidemiology Association. The citation for the term is: Porta, M. 2008. A Dictionary of Epidemiology, 5th ed. New York, NY: Oxford University Press. © 2008.

5Stedman, Thomas Lathrop. 2006. Stedman’s medical dictionary. Philadelphia: Lippincott Williams & Wilkins. © 2006.

6C.P. Farrington. 2004. Control without separate controls: Evaluation of vaccine safety using case-only methods. Vaccine 22(15-16):2064-2070. Elsevier Ltd. © 2004.

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