This report is organized into seven chapters and seven appendixes. Chapter 2 provides background on how vaccines are developed and recommended for U.S. children. Chapter 3 details existing surveillance and data systems for evaluating vaccine safety. Chapter 4 reports on the committee’s review of stakeholder concerns. Chapter 5 describes the methods used to perform and the results of a literature review on the scientific findings of studies of selected health outcomes and the recommended immunization schedule. Chapter 6 presents several methodological approaches for future studies. Chapter 7 summarizes the committee’s findings, conclusions, and recommendations. The appendixes include ACIP’s 2012 recommended immunization schedule for children (Appendix A), a glossary (Appendix B), a list of acronyms used in this report (Appendix C), the commissioned paper by Martin Kulldorff (Appendix D), agendas from public meetings held by the committee (Appendix E), biographical sketches of the committee members (Appendix F), and a chronological list of the IOM’s vaccine publications (Appendix G).


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IOM (Institute of Medicine). 2002. Immunization safety review: Multiple immunizations and immune dysfunction. Washington, DC: National Academy Press.

IOM. 2012. Adverse effects of vaccines. Washington, DC: The National Academies Press.

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