ORGANIZATION OF THE REPORT

This report is organized into seven chapters and seven appendixes. Chapter 2 provides background on how vaccines are developed and recommended for U.S. children. Chapter 3 details existing surveillance and data systems for evaluating vaccine safety. Chapter 4 reports on the committee’s review of stakeholder concerns. Chapter 5 describes the methods used to perform and the results of a literature review on the scientific findings of studies of selected health outcomes and the recommended immunization schedule. Chapter 6 presents several methodological approaches for future studies. Chapter 7 summarizes the committee’s findings, conclusions, and recommendations. The appendixes include ACIP’s 2012 recommended immunization schedule for children (Appendix A), a glossary (Appendix B), a list of acronyms used in this report (Appendix C), the commissioned paper by Martin Kulldorff (Appendix D), agendas from public meetings held by the committee (Appendix E), biographical sketches of the committee members (Appendix F), and a chronological list of the IOM’s vaccine publications (Appendix G).

REFERENCES

CDC (Centers for Disease Control and Prevention). 2011a. General recommendations on immunization—recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommendations and Reports: Morbidity and Mortality Weekly Report 60(2):1-64.

CDC. 2011b. Immunization Safety Office scientific agenda. Atlanta, GA: Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention.

CDC. 2012a. Final 2011 reports of nationally notifiable diseases. Morbidity and Mortality Weekly Report 61(32):624-637.

CDC. 2012b.Vaccination coverage among children in kindergarten—United States, 2011-12 school year. Morbidity and Mortality Weekly Report 61(33):647-652.

Dempsey, A.F., S. Schaffer, D. Singer, A. Butchart, M. Davis, and G.L. Freed. 2011. Alternative vaccination schedule preferences among parents of young children. Pediatrics 128(5):848-856.

Felkin, D.R., D.C. Lezotte, R.F. Hamman, D.A. Salmon, R.T. Chen, and R.E. Hoffman. 2000. Individual and community risks of measles and pertussis associated with personal exemptions to immunization. Journal of the American Medical Association 284(24): 3145-3150.

Fineberg, H.V. 2011. A perspective on vaccines: President’s address. Paper presented at Institute of Medicine Annual Meeting, Washington, DC.

Gregson, A.L., and R. Edelman. 2003. Does antigenic overload exist? The role of multiple immunizations in infants Immunology and Allergy Clinics of North America 23(4):649-664.

IOM (Institute of Medicine). 2002. Immunization safety review: Multiple immunizations and immune dysfunction. Washington, DC: National Academy Press.

IOM. 2012. Adverse effects of vaccines. Washington, DC: The National Academies Press.



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