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FIGURE 20-1 A digital commons for community-based analysis.

There are different types of data that the platform hosts and they come from different sources. For example, data can be obtained from pharmaceutical companies, disease consortia, investigators, patient advocacy organizations, and from government sponsored studies. There are seven stages in the data processing pipeline. The pipeline requires as input a combination of phenotypic, genetic, and expression data that need to be processed to determine a list of genes associated with diseases. The following figure shows an (idealized) description of these steps, each of which is likely to be performed by a different scientist who specializes in that area. One scientist acts as the project lead.

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FIGURE 20-2 Stages in lifecycle.

Stage 1: Data Curation— This consists of basic data validation to ensure integrity and completeness of the data (although some files use common formats, others have considerable variety.) The datasets include microarray data and clinical data. This step ensures that the format of the data is understood and the required metadata is present.

Stage 2: Statistical QC— Actual values in data are validated for quality to check for experimental artifacts. The checks made are dependent on the type of data set and involves the



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