E. cuniculi can contaminate transplantable tumors and alter host responses during their passage in mice (Arison et al., 1966), rats (Petri, 1965, 1966, 1967, 1968, 1969), and hamsters (Meiser et al., 1971).

Mice experimentally infected with E. cuniculi have reduced humoral antibody titers to sheep erythrocytes and reduced proliferative spleen cell responses to mitogens (Niederkorn et al., 1981; Didier and Shadduck, 1988), and altered natural killer cell activity (Niederkorn et al., 1983; Niederkorn, 1985). Altered humoral immune responses due to E. cuniculi infection also have been reported in rabbits (Cox, 1977; Cox and Gallichio, 1978; Waller et al., 1978).

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