INDEX

A

Abdominal enlargement, 260

hemopoietic system infections, 219

multiple system infections, 238

Abortions and stillbirths. 178, 260

Abscesses, 45, 49, 176, 178, 189, 260, 266

cervical, 74, 76, 189

face, orbits, and tail, 183-184

kidneys, 56, 74

liver, 56, 76, 129

lung, 45, 49

Adenovirus, 10, 123-126, 194

Age factors

digestive diseases, 85, 86, 93, 96, 99, 105, 107, 112-113, 117, 148 , 158

hemopoietic system infections, 201, 209, 213

multiple system infections, 238-239, 249

respiratory infections, 48, 83, 102

Agents (characterization)

central nervous system infections, 223. 227

definition of term, 32

digestive system infections, 86, 87, 91, 94-95, 98, 103-104, 112, 116-117, 119-120, 123-124, 127-128, 132-133, 139-140, 142, 146, 151 , 156-157, 159, 160, 162

genitourinary system infections. 232, 234

hemopoietic system infections. 199-200, 206, 212, 215, 218

multiple systems infections, 237, 241, 244, 248, 252-253

respiratory system infections, 36, 43-44. 48-49. 51-52, 54-55. 59, 62, 65-66, 70. 72, 73. 75. 77-78, 80. 81-82

skin and joint infections, 166-167, 172, 174-175, 177, 182-183, 186 , 188. 190, 192

see also Bacterial infections (agent characterization);

Viral agents;

Zoonotic agents

Airflow systems, general, 19-20

Alopecia, see Dermatitis and alopecia

Amputations, 164, 169, 172, 178, 197. 260

Amyloidosis, 181, 266

Anemia, 178. 211, 212, 213, 214, 263, 266

Ankylosis. 178, 266

Anorexia. 56. 172, 260

Arthritis, 11, 45. 47. 56. 94, 158, 164, 165, 173-176, 178, 266

Ascites, 123, 201. 211. 228, 247. 267

Aspicularis tetraptera, 159-160

Ataxia, 238, 260

Atelectasis. 83, 267

Athymic (nu/nu) mice, immune response, 260-261



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--> INDEX A Abdominal enlargement, 260 hemopoietic system infections, 219 multiple system infections, 238 Abortions and stillbirths. 178, 260 Abscesses, 45, 49, 176, 178, 189, 260, 266 cervical, 74, 76, 189 face, orbits, and tail, 183-184 kidneys, 56, 74 liver, 56, 76, 129 lung, 45, 49 Adenovirus, 10, 123-126, 194 Age factors digestive diseases, 85, 86, 93, 96, 99, 105, 107, 112-113, 117, 148 , 158 hemopoietic system infections, 201, 209, 213 multiple system infections, 238-239, 249 respiratory infections, 48, 83, 102 Agents (characterization) central nervous system infections, 223. 227 definition of term, 32 digestive system infections, 86, 87, 91, 94-95, 98, 103-104, 112, 116-117, 119-120, 123-124, 127-128, 132-133, 139-140, 142, 146, 151 , 156-157, 159, 160, 162 genitourinary system infections. 232, 234 hemopoietic system infections. 199-200, 206, 212, 215, 218 multiple systems infections, 237, 241, 244, 248, 252-253 respiratory system infections, 36, 43-44. 48-49. 51-52, 54-55. 59, 62, 65-66, 70. 72, 73. 75. 77-78, 80. 81-82 skin and joint infections, 166-167, 172, 174-175, 177, 182-183, 186 , 188. 190, 192 see also Bacterial infections (agent characterization); Viral agents; Zoonotic agents Airflow systems, general, 19-20 Alopecia, see Dermatitis and alopecia Amputations, 164, 169, 172, 178, 197. 260 Amyloidosis, 181, 266 Anemia, 178. 211, 212, 213, 214, 263, 266 Ankylosis. 178, 266 Anorexia. 56. 172, 260 Arthritis, 11, 45. 47. 56. 94, 158, 164, 165, 173-176, 178, 266 Ascites, 123, 201. 211. 228, 247. 267 Aspicularis tetraptera, 159-160 Ataxia, 238, 260 Atelectasis. 83, 267 Athymic (nu/nu) mice, immune response, 260-261

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--> B Bacillus piliformis, 12, 86, 126-131 Bacterial infections (agent characterization) arthritis, 165 barrier systems, 19, 20 digestive system infections, 126, 127-128, 131-132, 139-140, 142 genitourinary system infections, 232, 234 hemopoietic system infections, 212, 215 prevalence, general, 10, 11-12 respiratory. 43-44. 48-49, 51, 55, 62, 70, 72, 73, 75, 77-78, 80 skin and joint infections, 174-175, 177, 181, 182-183, 188 tests for. 22-24 see also specific agents Barbering, 196 Barrier techniques, 5, 6, 14-15, 17-20 central nervous system infections, 223, 226 digestive system infections. 109, 126, 138, 146, 150, 153 multiple system infections, 240, 246, 251 respiratory infections, 41, 47, 54, 61, 79, 81 skin and joint infections, 178-179 Behavioral trauma. 182, 195-197, 207 chattering (mice), 37, 44, 70, 261 circling and rolling, 143, 224, 261 hyperexcitability, 224, 263 reluctance to move, 44, 49, 70. 129, 134, 149, 201, 264 self-mutilation, 184, 185, 195 Birth weight reduced, 38, 134, 261 Biting, 195-196, 207 Bordetella bronchiseptica, 35 Brain, 78, 106, 107, 202, 228, 229, 238, 239, 246, 250, 267 Breeding, 13-16, 17-20 digestive system infections, 97, 99, 101 multiple system infections, 240 respiratory infections, 47 see also Cesarean derivation Bronchiectasis and bronchiolectasis, 42, 45, 49, 267 C Cages, general, 20 Canada, 7-8, 9, 10 Carcinogenesis/spontaneous neoplasia digestive system, 140, 141 hemopoietic system infections, 79. 171, 205-206, 217-221 leukemia, 79, 171, 205, 217-221, 240, 243, 245, 246, 247, 270 mammary glands, 192-195 multiple systems infections. 242, 247, 250 respiratory system, 47 salivary glands, 249 skin and joint infections, 192 Cell/tissue cultures, 22. 24, 276 central nervous system infections, 227 digestive system infections. 93, 101. 107, 122, 123, 137 genitourinary system infections, 232 hemopoietic system infections, 204. 206, 210-211 multiple system infections. 238, 244, 248, 250 prevalence data and, 11-12 respiratory infections, 40, 46, 48, 53, 57, 64, 71, 74, 79, 81, 82 skin and joint infections, 176, 183. 187, 203-204 Central nervous system infections. 222-230 agents, 223, 227 clinical signs, 224, 228 control225-226, 229 diagnosis, 225, 229 epizootiology, 223-224, 227-228 hosts, 223, 227 pathology, 224-225, 228-229 research history/prevalence, 222-223, 226-227, 237, 241 research interference, 226, 229-230 see also Brain; specific agents Cervical edema, 99, 261 Cesarean derivation central nervous system infections, 226 digestive system infections, 92, 102, 109, 115, 126, 128, 129, 131 , 138, 144, 146, 150, 153 genitourinary system infections, 233 hemopoietic system infections, 204, 213, 216 multiple systems infections, 246, 251 respiratory infections, 46, 50, 54, 58, 61, 69, 77, 79, 81, 83 skin and joint infections, 170, 175, 177, 178, 181, 186, 187, 190 Chattering (mice), 37, 44, 70, 261 Chlamydia psittaci, 35, 72 Chlamydia trachomatis, 35, 69-72, 188

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--> Cilia-associated respiratory bacillus (CAR), 34. 38, 48-50 Circling and rolling, 143, 224, 261 Citrobacter freundii. 86, 139-141 Clinical signs, 259-265 central nervous system infections, 224, 228 definition of term, 32 digestive system infections, 88, 92, 95, 99-100, 105, 113. 117, 121 , 125, 129, 134, 140, 143, 149, 152, 155, 157, 160, 161, 163 genitourinary system infections, 189, 233, 234 hemopoietic system infections, 201-202, 207, 212, 215, 219 multiple systems infections. 238, 242, 245, 249, 254-255 respiratory system infections, 37-38, 44, 49, 52, 56, 60, 63, 66, 70, 72, 74, 76, 78, 80, 82, 172, 189 skin and joint infections, 168, 172-173, 175, 178, 180, 183-184, 186, 188, 193 Colon and cecum, 107, 129, 130, 139, 140-141, 157, 158, 159, 161, 162, 163, 249, 267 Complement fixation (CF) central nervous system infections, 229 digestive system infections, 88, 89, 95, 96, 100, 108, 122, 126, 128 multiple system infections, 241, 243, 246 Conjunctivitis, 78, 80, 97, 99, 134, 178, 189, 261 Control techniques central nervous system infections, 225-226, 229 definition of term, 32 digestive system infections, 90, 93-94, 97, 101-102, 103, 106, 115-116 , 118, 122 genitourinary system infections, 233, 235 hemopoietic system infections, 204, 209-210, 213, 216, 221 multiple systems infections, 240, 243, 246, 251-252, 256 respiratory system infections, 40-41, 46-47, 50, 54, 58, 61, 64, 69, 71, 72, 75, 77, 79, 81, 83 skin and joint infections, 170-171, 173, 176, 178-179, 181, 185, 187, 190, 191, 194 see also Barrier techniques; Cesarean derivation; Monitoring and monitored animals; Vaccination Conventional animal, defined, 9 Convulsions, 224, 261 Corneal ulceration, 99. 261 Corynebacterium kutscheri.11-12. 34, 35. 54-58, 164, 178 Cutaneous papules, 191, 267 Cyanosis, 66, 70, 178, 238, 261 Cytomegalovirus, 87-94 D Dacryoadenitis, 189 Deaths, high and low mortality, 261-262 central nervous system infections, 224 digestive system infections, 105, 131. 140, 143 hemopoietic system infections, 201 skin and joint infections, 168, 172, 178, 179 Defined flora, 6, 9 Definitional issues, see Terminology Dehydration, see Diarrhea Demyelination and remyelination, 223, 225, 250, 267 Dermatitis and alopecia, 164. 262 infectious agents, 180, 181, 182, 183, 186, 191 noninfectious causes, 195-197 Dermatophytes, 185-187 Diabetes, 145, 205 Diagnosis, 259-274 central nervous system infections, 225, 229 definition of term, 32 differential diagnosis, 195-197 digestive system infections, 89-90, 93, 96, 101, 106, 115, 117-118, 122, 126, 130-131, 137, 141, 144, 150, 153. 155, 158, 160, 161, 163 genitourinary system infections, 233, 235 hemopoietic system infections, 203-204, 209, 213, 216, 220-221 laboratories for, 27 multiple systems infections, 239, 242-243, 246, 250, 255-256 respiratory system infections, 40, 46. 50, 53-54, 57-58, 61, 64, 67-68, 71, 72. 74, 77, 79, 81, 83 skin and joint infections, 164, 169-170, 173, 175, 181, 185, 187, 188-189, 191, 194, 195-197 see also Cell/tissue cultures: Clinical signs; Pathology; Serologic tests; Stain techniques

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--> Diarrhea, 20, digestive system infections, 102, 105. 111-118, 121, 129, 134, 140 , 149 hemopoietic system infections, 202, 262 skin and joint infections, 178 Differential diagnosis, skin infections, 195-197 Digestive system infections, 85-163 agents. 87, 91, 94-95, 98, 103-104, 11, 116-117, 119-120, 123-124, 127-128, 132-133, 139-140, 142, 146, 151, 156-157, 159. 160, 162 clinical signs, 88, 92, 95, 99-100, 105, 113, 117, 121, 125, 129, 134, 140, 143, 149, 152, 155, 157, 160, 161, 163 control, 75, 90, 93-94, 97, 101-102, 106, 115-116, 118, 122, 126, 131, 137-138, 141, 144-145, 150, 153, 156. 159. 161, 163 diagnosis, 89-90, 93, 96, 101, 106, 115, 117-118, 122, 126, 130-131, 137, 141, 144, 150, 153, 155, 158, 160, 161, 163 epizootiology, 88, 91-92, 95, 99, 104, 112-113, 117, 120-121, 124-125, 128-129, 133-134, 140, 142-143, 149, 152, 155, 157, 159, 161, 163 historic perspectives, 87, 91, 94, 97-98, 102-103, 111-112, 116, 118-119, 123-124, 127, 132, 139, 141-142 hosts, 87-88, 91, 95, 98-99, 104, 107-108, 112, 120, 124, 133, 142 , 149, 152, 155, 157, 159, 161, 162 parasites, 127. 145-163 pathology. 88-89, 92-93, 95-96, 100-101, 105-106, 113-114, 117, 121-122 , 125, 129-130, 134-137, 140-141, 143-144, 149-150, 152-153, 155, 158, 160, 161, 163 research interference, 90-91, 94, 97, 102, 109-111, 116, 118, 122-123, 126, 131, 138-139. 141, 145, 150-151, 153-154, 156, 158, 160, 161, 163 see also specific agents and organs DNA viruses (agent characterization) digestive system infections, 87, 91, 94-95, 123-124 multiple system infections, 237, 241, 244. 248 respiratory infections, 81 skin and joint infections, 166-167 see also specific agents Dwarf tapeworm, 154-156 Dyspnea, 44. 52, 56. 66, 70, 212, 219, 262 E Ear pathologies, 53, 63, 76, 143, 189. 195, 267-268 Ectromelia virus, 164, 165-171 Ectoparasites, 179-195 Empyema, 74, 268 Encephalitis, 102, 107, 224-225, 239, 268 Encephalitozoon cuniculi.222, 226-230 Encephalomyelitis, 102, 209, 222-225, 228, 250 Endometritis, 45, 268 Endoparasites, 144-163 Entamoeba muris, 12, 160-161 Enzyme-linked immunosorbent assay (ELISA), 22, 23 central nervous system infections, 229 digestive system infections, 88, 89-90, 93, 95, 96, 97, 101, 103, 108, 115, 122, 130 hemopoietic system infections, 203 multiple system infections, 242, 246, 250 respiratory infections, 40, 43, 46, 47, 50, 54, 57, 61, 81 skin and joint infections, 166, 169-170, 175 Eosinophilic crystals in lung, 39, 268 Eperythrozoon coccoides.198, 214-217 Epizootiology central nervous system infections, 223-224, 227-228 definition of term, 32 digestive system infections, 88, 91-92, 95, 99, 104, 112-113, 117, 120-121, 124-125, 128-129, 133-134, 140, 142-143, 149, 152, 155, 157, 159, 161, 163 genitourinary system infections, 232-233, 234 hemopoietic system infections, 200-201, 207, 212, 215, 219 multiple systems infections, 237-238, 242, 245, 248-249, 254 prevalence data, general, 7-12 respiratory system infections, 37-38, 44, 49, 52, 55-56, 59-60, 62-63 , 66, 70, 73, 76, 78, 82, 248, 254 skin and joint infections, 167-168, 172, 177, 180, 186, 188, 191, 193 Escherichia coli, 126 Exanthema, 173. 268 Eye pathologies, 44, 49, 97, 100, 102, 189 see also Conjunctivitis; Lacrymal glands

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--> F Facial abscesses, 183-184 G Genitourinary system infections, 231-235 agents, 232, 234 clinical signs, 189, 233, 234 control, 233, 235 diagnosis, 233, 235 epizootiology, 44, 232-233, 234 hosts, 232, 234 pathology, 45. 233, 235 research history/prevalence, 231-232, 234 research interference, 234, 235 see also specific agents and organs Germfree animal, defined, 6 see also Pathogen-free animal Giardia muris, 12, 86, 151-154 Glomerulonephritis, 56, 202, 209, 268 Gnotobiotic animal and methods, defined, 6, 9 Growth retardation, 37, 102, 117, 262 H Haemobartonella muris, 198, 211-214 Hair digestive system infections, 149, 152, 157 respiratory infections, 66 skin conditions, noninfectious, 196, 197 Hantaviruses, 251-256 Harderian glands, 101 Head tilt, 44, 49, 263 Heart, 129, 268 Hemagglutination inhibition test (HAI), 45, 61, 83, 120, 122, 170, 173, 225, 241, 243, 246 Hemopoietic system infections, 198-221 agents, 199-200, 206, 212, 215, 218 clinical signs, 201-202, 207, 212, 215, 219 control, 204, 209-210, 213, 216, 221 diagnosis, 203-204, 209, 213, 216, 220-221 epizootiology, 200-201, 207, 212, 215, 219 hosts, 200, 206, 212, 215, 218 leukemia, 79, 171, 205, 217-221, 240, 243, 245, 246, 247 pathology, 202-203, 207-209, 212-213, 215-216, 219-220 research history/prevalence, 199. 205-206, 211, 214, 217 research interference, 204-205, 210-211, 213-214, 216-217, 221 see also specific agents and organs Hemoglobinuria, 178, 212, 213. 263 Hemorrhages. 268 intestines, 130. 140 multiple system infections, 239, 254-255 skin and joint infections, 173. 193 Hepatic system, see Liver Hepatitis virus, 20, 84, 86, 98. 102-111, 112 Herpesviruses, 87. 94 Historical perspectives/disease prevalence, 7-8, 9-10 central nervous system infections, 222-223, 226-227, 237, 241 definition of term, 32 digestive system infections, 87, 91, 94, 97-98, 102-103, 111-112, 116, 118-119, 123-124, 127. 132, 139, 141-142 genitourinary system infections, 231-232, 234 gnotobiotic methodology, 4, 9 hemopoietic system infections, 199, 205-206, 211, 214, 217 multiple systems infections, 236-237, 241, 243, 247, 252 respiratory system infections, 35-36, 42-43, 48, 51, 54-55, 59, 62 , 65, 69, 72, 73, 75, 77, 80, 81, 97-98, 187-188 skin and joint infections, 166, 171-172, 173-174, 177, 179-180, 182 , 185, 187-188, 190, 192 Hosts central nervous system infections, 223, 227 definition of term, 32 digestive system infections, 87-88, 91, 95, 98-99, 104, 107-108, 112, 120, 124, 133. 142, 149, 152, 155, 157, 159, 161, 162 genitourinary system, 232, 234 hematopoietic system infections, 200, 206, 212, 215, 218 multiple systems infections, 237, 241. 245, 248, 253-254 respiratory system infections, 36-37, 44. 49, 52, 55, 59, 62, 66, 70, 72, 73, 75, 78, 82 skin and joint infections, 167, 172, 175, 177, 180, 183, 186, 188, 191, 193 see also Zoonotic agents; Transplants, tissues and organs

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--> Hunched posture, see Reluctance to move Hymenolepis nana.154-156 Hyperexcitability. 224, 263 Hypersensitivity. cutaneous. 181, 184, 269 H-1 virus, 240-243, 246 I Immune response, 275 athymic (nu/nu) mice, immune response, 260-261 central nervous system infections, 228, 229, 230 digestive system infections, 89, 96, 107-108, 109-110, 114, 125, 130, 135, 137, 143, 144, 151, 153, 154, 158 glomerulonephritis, 56, 202, 209 hemopoietic system infections, 198, 202, 203, 208-209, 210, 211, 212, 216-217 multiple system infections, 240, 243, 247, 249 respiratory infections, 35, 39, 41-42, 45-46, 50, 58, 64, 66, 67, 68, 69 skin and joint infections. 171, 176, 180, 185, 194 see also Serologic tests Inapparent infections, see Subclinical infections Inclusions, 269 intracytoplasmic, skin, 169, 191 intracytoplasmic and intranuclear, 250 intranuclear, 83, 88, 92, 96, 125 Indirect immunofluorescent antibody test (IFA), 22, 23 central nervous system infections, 229 digestive system infections, 88, 89, 95, 96, 101, 115, 117-118, 128 , 130 hemopoietic system infections, 200, 203, 216, 204, 221 multiple system infections, 242-243, 246 respiratory infections, 40, 50, 68, 71 skin and joint infections, 170 Infarcts, 53, 239, 269 Interference with research, see Research complications Intestines, small, 269 blunting of villi, 107, 114, 117, 125 enteritis, 107, 117, 121, 125, 129, 130, 150, 152-153, 154-155 helminth parasite, 156 ileocecocolitis, 130, 136 protozoan parasites, 146, 149-151, 152-153 syncytial epithelial giant cells, 107, 117 J Japan. 7-8, 10, 12 Jaundice. 105, 121, 238, 239, 263 Joints, see Skin and joint infections K Keratitis, 100 Keratoconus. 99, 181, 263 Kidneys digestive system infections, 91, 92, 98, 121, 122, 126 genitourinary system infections, 228, 229, 233 multiple systems infections, 244, 248. 249. 250. 254 respiratory infections. 56, 74 Kilham rat virus, 10, 58, 236-240, 241. 242, 246 Klebsiella pneumoniae, 35, 72-75 K virus, 35, 81-84 Kyphosis, 178, 263 L Lacrymal glands, 92, 93, 97, 99, 100, 102 Lactic dehydrogenase-elevating virus, 198, 205-211, 216 Laryngitis, 45, 49, 270 Leptospira interrogans serovar ballum.231-234 Leukemia. 79. 171, 205, 217-221, 240, 243, 245, 246, 247, 270 Life cycles, parasites digestive system, 146, 152, 154-155, 157, 159, 160-161, 162 skin and joints, 180 Listeria monocytogenes.211 Litter size reduced, 37, 134, 263 Liver, 268, 270 central nervous system infections, 226 digestive system infections, 86, 98, 102-111, 112, 121, 129, 135, 136, 138 hemopoietic system infections, 202-203, 207, 216 hepatitis, 20, 53, 84, 86, 98, 102-111, 112, 268-269 jaundice, 105, 121, 238, 239, 263 multiple system infections, 238, 239, 243, 249 respiratory infections, 53, 56, 63, 74, 84 skin and joint infections, 169, 178

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--> Lung pathology. 10, 35, 39, 45, 49, 52, 73, 83, 173, 249, 254, 255 Lymphadenopathy. 74, 76, 129, 178, 181, 219, 263, 270 Lymph nodes, 263, 271 digestive system infections, 95, 96, 100, 136 hemopoietic system infections, 207, 208, 219 respiratory infections, 63, 74, 76 skin and joint infections, 169, 178, 181, 189 Lymphocytic choriomeningitis virus, 10, 198, 199-205, 216 Lymphocytopenia, 208, 271 M Malaria, 211, 214, 217 Mammary tumor virus, 192-195 Mastitis, 189, 263, 271 Mediastinitis, 53 Minute virus of mice, 243-247 Mites, 12, 179-182 Monitoring and monitored animals, 9, 13, 14, 15, 18, 21-27 digestive system infections, 97, 100 skin and joint infections, 179 Mouse adenovirus, 10, 123-126 Mouse cytomegalovirus, 87-91, 145 Mouse hepatitis virus, 84, 102-111 Mouse mammary tumor virus, 192-195 Mouse minute virus, 243-247 Mouse papule virus, 190-191 Mouse rotavirus, 20, 86, 111-116 Mouse thymic virus, 94-97 Mousepox virus, 164-171 Multiple systems infections, 236-256 agents, 237, 241, 244, 248, 252-253 clinical signs, 173, 238, 242, 245, 249, 254-255 control, 240, 243, 246, 251-252, 256 diagnosis, 239, 242-243, 246, 250, 255-256 epizootiology, 237-238, 242, 245, 248-249, 254 hosts, 237, 241, 245, 248, 253-254 pathology, 238-239, 242, 245-246, 249-250, 255 research history/prevalence, 236-237, 241, 243, 247, 252 research interference, 240, 243, 246-247, 252, 256 Murine respiratory mycoplasmosis (MRM), 44-45, 46. 47. 48, 49, 50 Mycobacterium avium-intracellulare.62-64 Mycoplasma arthritidis.11, 164. 173-176 Mycoplasma collis.35, 80-81 Mycoplasma muris.231, 234-235 Mycoplasma neurolyticum.35, 77-79 Mycoplasma pulmonis, 33-34, 36, 38, 40, 42-48, 50, 174, 188, 231 Myobia musculi, 179-182 Myocoptes musculinus.182 N Necropsy digestive system infections, 108, 117, 130, 158 respiratory infections, 53, 68, 74 Nematodes, 156-157, 159 Neoplasia, 271 leukemia, 79, 171, 205, 217-221, 240, 243, 245, 246, 247. 270 mammary glands, 192-195 salivary glands, 249 see also Carcinogenesis/spontaneous neoplasia O Otitis media, 143, 195, 189, 267 P Pallor, see Anemia Panophthalmitis, 189, 263 Papule virus, 190-191 Paralysis, 178, 207, 209, 224, 249, 250, 263-264 Parasitic infections, 45 blood. 214, 216, 217 digestive system, 127, 145-163 ectoparasites, 179-195 endoparasites. 144-163 genitourinary system, 226-230 multiple systems, 250 prevalence data, 12 skin and joints, 179-185 testing for, 24 see also Life cycles, parasites; Protozoa Pasteurella pneumotropica.11, 35, 187-190 Pathogen-free animal, 6, 9, 13-16 see also Specific pathogen-free animal

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--> Pathology, 266-274 central nervous system infections, 224-225, 228-229 definition of term, 32 digestive system infections, 88-89, 92-93, 95-96, 100-101, 105-106, 113-114, 117, 121-122, 125, 129-130, 134-137, 140-141, 143-144, 149-150 , 152-153, 155, 158, 160, 161, 163 genitourinary system infections, 233, 235 hemopoietic system infections, 202-203. 207-209, 212-213, 215-216, 219-220 multiple systems infections, 238-239, 242, 245-246, 249-250, 255 respiratory system infections, 38-40, 44-45, 49-50, 52-53, 56-57, 60-61, 63, 66-68, 71, 72, 74, 76, 78-79, 81, 82-83, 105, 106, 107, 121, 173, 255 skin and joint infections, 168-169, 173, 175, 178, 180-181, 184-185, 186, 188, 191, 193-194 see also Clinical signs; specific organs and systems Peritonitis, 53, 57, 136, 271 Pharmacokinetics, 131, 275 Photophobia, 99, 178, 264 Pinworm, 20, 156-160 Pleural effusion, 39, 173, 271 Pleuritis, 53, 57, 271 Pneumocystis carinii, 35, 64-69 Pneumonia, 10, 76, 173, 271-272 broncho, 45, 49, 53 embolic, 56 interstitial, 38, 60, 71, 83. 100, 106-107 Pneumonia virus of mice. 35, 50, 59-62, 82 Pododermatitis, 184, 264, 272 Polioencephalomyelitis, see Encephalomyelitis Polyoma virus. 19, 81, 205, 247-251 Polyplax serrata, 215 Polypnea. 44, 264 Poxviruses, 164-171, 171-173, 178 Preputial gland abscesses, 184 Priapism, 178, 180, 264 Protozoa central nervous system infections, 227 digestive system infections, 146, 149-153, 160, 162 respiratory infections, 65 serologic tests, 22 Pruritis, 178, 180, 183, 264 Pseudomonas aeruginosa, 11, 141-145 Pseudotuberculosis, 57 R Radfordia affinis.182 Radioimmunoassays. 54, 115 Rat coronavirus, 58 Rat cytomegalovirus, 91-94 Rat rotavirus, 116-118 Rectal prolapse, 139, 140, 157, 264 Reluctance to move, 44, 49, 70, 129, 134, 149, 201, 264 Reovirus-3, 10, 19. 118-123 Research, see Historical perspectives/disease prevalence Research complications, 3, 275-276 central nervous system infections, 226, 229-230 definition of term, 32 digestive system infections. 90-91, 94, 97, 102, 109-111, 116, 118 , 122-123, 126, 131, 138-139, 141, 145, 150-151, 153-154, 156, 158 , 160, 161, 163 genitourinary system infections, 234, 235 hemopoietic system infections, 204-205, 210-211, 213-214, 216-217, 221 multiple systems infections, 240, 243, 246-247, 252, 256 respiratory system infections, 41-42, 47-48, 50. 54, 58, 61-62, 64 , 69, 72, 75, 77, 79, 81, 84, 102, 123 significance, general definition, 31 skin and joint infections, 171, 173, 176, 179, 181-182, 185, 187. 190, 191, 194-195 Respiratory system infections, 33-84, 231 agents, 34, 36, 43-44, 48-49, 51-52, 54-55, 59, 62, 65-66, 70, 72, 73, 75, 77-78, 80, 81-82 airflow barrier systems. 19-20 clinical signs, 37-38, 44, 49, 52, 56, 60, 63, 66, 70, 72, 74, 76, 78, 80, 82, 172, 189 control techniques, 40-41. 46-47, 50, 54, 58, 61, 64, 69, 71, 72, 75, 77, 79, 81, 83 diagnosis. 40, 46, 50, 53-54, 57-58, 61, 64, 67-68, 71, 72, 74, 77 , 79, 81, 83 epizootiology. 37-38, 44, 49, 52, 55-56, 59-60, 62-63, 66, 70, 73, 76, 78, 82, 248, 254 hosts, 36-37, 44, 49, 52, 55, 59, 62, 66, 70, 72, 73, 75, 78, 82 pathology, 38-40, 44-45, 49-50, 52-53, 56-57, 60-61, 63, 66-68, 71 , 72, 74, 76, 78-79, 81, 82-83, 105, 106, 107, 121, 173, 255

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--> research history/prevalence, 33, 35-36, 42-43, 48, 51, 54-55, 59, 62, 65, 69, 72, 73, 75, 77. 80, 81, 97-98, 103, 187-188 research interference, 41-42, 47-48, 50, 54, 58, 61-62, 64, 69, 72 , 75, 77, 79, 81, 84, 102, 123 see also specific agents and organs Rhinitis, 45, 53, 76, 272 Ringtail. 164, 197 RNA viruses (agent characterization) central nervous system infections, 223 digestive system infections, 86, 98, 103-104, 112, 116, 119-120 hemopoietic system infections, 199-200, 206, 218 multiple systems infections. 252-253 respiratory infections, 36, 59, 84, 98 skin and joint infections, 192 see also specific agents Rolling, see Circling and rolling Rotavirus, 20, 86, 111-118 Runting, see Wasting syndrome S Salivary glands and saliva, 87, 88, 91-92, 95, 96, 99, 100, 101, 102, 249, 272 Salmonella enteritidis,11, 86, 132-139, 169, 178 Salpingitis, 45 Sampling, 25-26 Scrotal cyanosis, 238 Scrotal hemorrhage, 239 SDA/RCV, 10 Self-mutilation, 184, 185, 195 Sendai virus, 10, 34, 35-41, 50, 58 Sentinel animals, 27 Septicemia, 272 digestive system infections, 136, 143, 144, 145 genitourinary system infections, 233 respiratory infections, 54, 56-57 skin and joint infections, 178, 203 Serologic tests, 22-24 central nervous system infections, 225-226, 227, 229 digestive system infections. 101, 103, 117-118, 124, 128, 133 genitourinary system infections, 232, 233 multiple system infections, 237, 239-243, 246, 255 respiratory infections, 43, 54, 61, 68, 74, 75 skin and joint infections. 169, 175 see also Enzyme-linked immunosorbent assay; Hemagglutination inhibition test; Indirect immunofluorescent antibody test Sialodacryoadenitis virus, 35, 43, 45, 58, 97-102, 189 Silver stain, see Stain techniques Skin and joint infections. 164-197 agents, 166-167, 172, 174-175, 177, 182-183, 186, 188, 190, 192 clinical signs. 168, 172-173, 175, 178, 180, 183-184, 186, 188, 193 control, 170-171, 173, 176, 178-179, 181, 185, 187, 190, 191, 194 diagnosis, 164, 169-170, 173, 175, 181, 185, 187, 188-189, 191, 194 epizootiology, 167-168, 172, 177, 180, 186, 188, 191, 193 hosts, 167, 172, 175, 177, 180, 183, 186, 188, 191, 193 pathology, 168-169, 173, 175, 178, 180-181, 184-185, 186, 188, 191 , 193-194 parasites, 179-182 research history/prevalence. 166, 171-172, 173-174, 177, 179-180, 182, 185, 187-188, 190, 192 research interference, 171. 173, 176, 179, 181-182, 185, 187, 190, 191, 194-195 see also Dermatitis and alopecia; specific agents Skin conditions, noninfectious, 195-197 Skin ulceration, 180, 183, 186, 264 Sneezing, 44, 74, 99, 264 Snuffling, 44, 52, 264 Social behavior, see Behavioral trauma Specific pathogen-free animal, 6, 9 central nervous system infections, 226 digestive system infections, 153 hemopoietic system infections, 204, 216 multiple system infections, 240, 246, 255 skin and joint infections. 176 Spinal cord, 239, 250, 272 Spironucleus muris, 12, 86, 146, 149-151 Spleen, 239, 272-273 central nervous system infections, 226, 230 digestive system infections, 92, 95, 96, 106, 135, 136, 151 hemopoietic system infections, 207, 213, 214, 215-216

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--> respiratory system infections, 41, 51, 63 skin and joint infections, 169, 171, 178 Stain techniques digestive system infections, 130, 150, 161, 163 hemopoietic system infections, 213, 216, 218 respiratory infections, 50, 68 Standards, 13-14, 21 Staphylococcus aureus.123, 164-165, 182-185 Streptobacillus moniliformis, 164, 169, 176-179 Streptococcus pneumoniae, 34, 51-54 Streptococcus pyogenes, 35, 75-77 Subclinical infections, 263, 276 central nervous system infections, 224 digestive system, 87, 88, 92, 95, 97, 99-100, 105, 111, 128, 129, 131, 132, 134, 149, 151, 152, 157, 160, 161 genitourinary system infections, 233 hemopoietic system infections. 201, 207, 210, 212, 214 multiple system infections, 238, 240, 242, 245 respiratory, 33, 37, 44, 46, 47, 54, 55, 57, 60, 66, 69, 70, 72, 78, 80, 82, 174 skin and joints, 11, 168, 172, 174, 175, 176, 178, 180 Surveillance, see Monitoring and monitored animals Swelling (endema), 99, 169, 178, 197, 264 Symptoms, see Clinical signs; specific symptoms Syphacia obvelatalmuris, 20, 156-158 Synctal giant cells. 38, 45, 107, 117, 273 T Terminology agent characterization, 31-32 barrier techniques, 6, 17-18 infection vs disease, 3-4 microbial and pathogen terms, 4-9, 13 Teratogenic effects, 239, 273 Testes, 53, 239, 273 Theiler's virus, 10-11, 222-226 Thrombosis, 239, 273 Thymus, 94-97, 100, 207, 208, 220, 273 Tissue cultures, see Cell/tissue cultures Toolan H-1 virus, 10 Tracheitis, 39, 45, 49, 273 Transplants, tissue and organs, 276 central nervous system infections, 228, 230 digestive system infections, 86, 90, 94, 104, 107, 121, 122-123, 131, 138 hemopoietic system infections, 198, 199, 200, 203-211, 213, 214 multiple system infections, 238, 240, 243, 245, 246, 249, 250, 251 , 255-256 respiratory infections, 41, 42, 84, 84 skin and joint infections, 176 Transportation of animals, general, 13-14 Tremors, 224, 264 Tritrichomonas muris.12, 162-163 Tumors, 276 central nervous system infections, 228, 230 digestive system infections, 86, 90, 94, 104, 107, 121, 122-123, 131, 138 hemopoietic system infections, 198, 199, 200, 203-211, 213, 214 multiple system infections, 238, 240, 243, 245, 246, 249, 250, 251 , 255-256 respiratory infections, 41, 42, 48, 84 skin and joint infections, 176, 192-195, 199 see also Neoplasia Tyzzer's disease, 127-131 U United Kingdom, 7-8, 9, 10 Uterine pathologies, 45, 239, 274 V Vaccination digestive system infections, 116, 144-145 respiratory infections, 41, 54 skin and joint infections, 170-171 Viral agents prevalence, general, 7-8, 9-10 respiratory, 54 skin and joint infections, 190 tests for, 22-24 see also DNA viruses (agent characterization); Poxviruses; RNA viruses (agent characterization); specific agents W Wasting syndrome, 105, 238, 246, 249, 265 see also Anorexia: Weight loss Weaning behavior, 195-196

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--> Weight loss birth weight reduced, 38, 134, 261 digestive system infections, 102, 105, 116, 134, 140, 149, 151, 152 , 155 emaciation, 262 hemopoietic system, 201, 212 multiple systems, 238, 250 respiratory infections, 44, 52, 56, 66, 67, 70 skin and joint infections, 178 West Germany, 12 Whisker-trimming, 196 Wounds, 195-196 X X-irradiation, 92, 131, 152, 154, 171, 205, 209, 214 Z Zoonotic agents. 276 central nervous system infections, 229 digestive system infections, 116, 118, 133, 138, 154, 156 genitourinary infections, 230, 232, 233, 234 hemopoietic system infections. 199, 200, 201-202, 204, 205 multiple system infections, 251-256 respiratory infections. 52 skin and joint infections, 172, 177, 178, 179, 185-187