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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences. National Academy of Engineering, and Institute of Medicine.

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and upon its own initiative to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine.

The National Research Council was established by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and National Academy of Engineering in the conduct of their services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice-chairman, respectively, of the National Research Council.

This project was supported by the National Cancer Institute, National Institutes of Health, under contracts NO1-CM-57644 and NO1-CM-07316. administered by the Division of Cancer Treatment.

Infectious diseases of mice and rats / Committee on Infectious Diseases of Mice and Rats. Institute of Laboratory Animal Resources. Commission on Life Sciences. National Research Council.

p. cm.

Includes bibliographical references.

Includes index.

ISBN 0-309-06332-9

1. Mice—Infections. 2. Rats—Infections. 3. Laboratory animals—Infections. 4. Mice as laboratory animals. 5. Rats as laboratory animals. I. Institute of Laboratory Animal Resources (U.S.) Committee on Infectious Diseases of Mice and Rats.

[DNLM: 1. Animals, Laboratory. 2. Communicable Diseases—veterinary. 3. Mice. 4. Rats. QY 60.R6 I43]

SF996.5.I54 1990

636'.93233—dc20

DNLM/DLC

for Library of Congress 90-6152

CIP

Copyright © 1991 by the National Academy of Sciences

No part of this book may be reproduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher, except for the purposes of official use by the United States Government.

Printed in the United States of America

First Printing, May 1991

Second Printing, May 1997

Third Printing, November 1998



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