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APPENDIX C PROPOSAL REVIEW CRITERIA The committee used the points below to help guide its review of the proposals. The reviewers were asked to comment on the strengths and weaknesses of the proposals by considering the following: Level of scientific merit 1. Potential to advance understanding of an important problem or question in the field; potential for breakthrough science resulting in new discoveries and understanding 2. Impact that successful completion of the proposed research would have on the knowledge, methods, and current barriers in the field 3. Project is scientifically and technologically feasible with clear, well-developed, and appropriate goals, objectives, and approach to the proposed studies Justification for requested time allocation 1. Clear and well-justified need for multi-microsecond simulation time 2. Clear and convincing justification that the length and number of proposed simulation runs and node-hours requested are necessary and sufficient to achieve the scientific objectives Investigator qualifications and past accomplishments 1. Appropriate experience and training to successfully conduct the proposed studies 2. Evidence of knowledge and prior experience with molecular simulations 3. Past publications 11