NMR data with isothermal titration calorimetry assays and conformational modeling using ultra-long molecular mechanics calculations performed on the ANTON platform provides atomistic ensembles with high spatial and temporal resolution, as well as mechanistic insight into disordered protein function. The Showalter laboratory also applies similar biophysical techniques to study non-specific double-stranded RNA binding by double-stranded RNA binding proteins involved in microRNA maturation. Dr. Showalter received his Ph.D. from Washington University School of Medicine in St. Louis, MO, where he was an NSF predoctoral fellow. He was an NIHNRSA postdoctoral fellow at the National High Magnetic Field Laboratory in Tallahassee, FL.
Feng Wang, Ph.D., is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Arkansas. He was formerly an Assistant Professor in the Department of Chemistry at Boston University from 2005 to 2012. Dr. Wang’s research focuses on developing high quality force fields, free energy calculations, and enhanced sampling. He received his B.S. in Chemistry from Peking University (1998) and Ph.D. in Theoretical Chemistry from the University of Pittsburgh (2003) with Prof. Kenneth D. Jordan. He did post-doctoral research in computational physical chemistry at the University of Utah with Professor Gregory A. Voth. While at the University of Pittsburgh, Dr. Wang received an IBM graduate student award in 2001 and a Mellon Fellowship in 2002. He received a NSF CAREER Award in 2007 and an HP outstanding Junior Faculty Award in 2010.
Arieh Warshel, Ph.D., is a Distinguished Professor of Chemistry and Biochemistry at the University of Southern California. Dr. Warshel is known for his work on computational biochemistry and biophysics, in particular for pioneering computer simulations of the functions of biological systems, and for developing what is known today as Computational Enzymology. Dr. Warshel made major contributions in introducing computational methods for structure function correlation of biological molecules, pioneering and co-pioneering programs, methods and key concepts for microscopic studies of functional properties of biological molecules including Cartezian based force field programs, the QM/MM method for simulating enzymatic reactions, the first molecular dynamic simulation of a biological process, microscopic electrostatic models for proteins, and free energy perturbation in proteins and other key advances. He received his BS degree in Chemistry, Summa Cum Laude, from Technion Israel in 1966, and his M.S. and Ph.D. degrees in Chemical Physics in 1967 and 1969, respectively, from the Weizmann Institute of Science, Israel. After his PhD, he did postdoctoral work at Harvard University. From 1972 to 1976, he was at the Weizmann Institute and at the MRC Laboratory for Molecular Biology in Cambridge, England. In 1976 he joined the faculty of the Department of Chemistry at USC. He is an elected member of the United States National Academy of Sciences (2009), a fellow of the Royal Society of Chemistry (2008), a fellow of the Biophysical Society (2000), and an Alfred P. Sloan fellow (1978). He has received awards including the Annual Award of the International Society of Quantum Biology and Pharmacology (1993); Tolman Medal (2003); President’s award for computational biology from the ISQBP (2006); and RSC Soft Matter and Biophysical Chemistry Award (2012).