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PART III Diagnosis and ResearchComplications of Infectious Agents INTRODUCTION Part III is intended to serve as an index for diagnostic problem solving in situations for which infectious agents of mice and rats may be responsible. Three index categories, clinical signs, pathology, and research complications, are listed in alphabetical order. When a problem suspected of being caused by an infectious agent is encountered, one or more of these lists should be consulted to identify quickly the most likely causative agents. One should then consult the informa- tion in Part II on the most likely candidate agents to narrow the list of possible causes and to devise further testing to make the definitive diagnosis. Once the precise causers) is known, specific corrective measures can be implemented. 70

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 71 CLINICAL SIGNS Abdominal Enlargement Kilham rat virus Leukemia viruses, murine Lymphocytic choriomeningitis virus Abortions and Stillbirths Strep to ba c illus mon iliform is Abscesses Cervical Pasteurella pneumotropica Facial, orbital, and tail Staphylococcus aureus Preputial gland Pasteurella pneumotropica Staphylococcus aureus Alopecia (See Dermatitis and Alopecia) Amputations, Necrotic, of Limbs or Tails Corynebacterium kutscheri Ectromelia virus Mycoplasma arthritidis Ringtail Streptobacillus moniliformis Annular Constrictions of Tail Ringtail Anorexia Corynebacterium kutscher' Ectromelia virus Ataxia Kilham rat virus Athymic (nu/nu) Mice, More Susceptible than Immunocompetent Mice to: Cytomegalovirus, mouse Encephalitozoon cuniculi Giardia muris Hepatitis virus, mouse Pneumocystis carinii Pneumonia virus of mice Polyoma virus Sendai virus Spironucleus muris Staphylococcus aureus Syphacia spp. Athymic (nu/nu) Mice, Equally or Less Susceptible than Immunocompetent Mice to: Bacillus piliformis Lymphocytic choriomeningitis virus Mycoplasma pulmonis Reovirus-3 Streptococcus pneumoniae Athymic (nu/nu) Mice, Not Susceptible to: Myobia musculi Myocoptes musculinus Birth Weight Reduced Salmonella enteritidis Sendai virus Cervical Edema Sialodacryoadenitis virus Chattering (Mice) Mycoplasma pulmonis Sendai virus Circling (or Rolling) Kilham rat virus Pseudomonas aeruginosa Streptobacillus moniliformis Theiler's virus Conjunctivitis Ectromelia virus

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72 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS Pasteurella pneumotropica Salmonella enteritidis Sialodacryoadenitis virus Staphylococcus aureus Streptobacillus moniliformis Convulsions Theiler's virus Corneal Ulceration Sialodacryoadenitis virus Cyanosis Salmonella enteritidis Streptobacillus moniliformis Deaths, High Mortality (greater there 50%) Possible Bacillus piliformis Citrobacter freundii (Biotype 4280) Ectromelia virus Hepatitis virus, mouse (infant mice) Salmonella enteritidis Streptobacillus moniliformis Theiler's virus Deaths in Neonates Hepatitis virus, mouse Sendai virus Deaths Unlikely (in uncomplicated infections) Adenoviruses, mouse Aspicularis tetraptera Coronavirus, rat Cytomegalovirus, mouse Encephalitozoon cuniculi Entamoeba muris Giardia muris Har~taviruses Hymenolepis nana H-1 virus Lactic dehydrogenase-elevating virus Minute virus of mice Mycoplasma arthritidis Pasteurella pneumotropica Pneumocystis carinii Pneumonia virus of mice Polyoma virus Pseudomonas aeruginosa Radfordia affinis Sialodacryoadenitis virus Spironucleus muris Syphacia spp. Theiler's virus Thymic virus, mouse Tritrichomonas muris Deaths, Usually Low Mortality Corynebacterium kutscheri Hepatitis virus, mouse Kilham rat virus Lymphocytic choriomeningitis virus Mycoplasma pulmonis Rotavirus, mouse Salmonella enteritidis Sendai virus Streptococcus pneumoniae Dehydration (See Diarrhea) Dermatitis and Alopecia Due to Infectious Agents Dermatophytes (fungi) Ectromelia virus Myobia musculi Myocoptes musculinus Pasteurella pneumotropica Papule virus, mouse Staphylococcus aureus Due to Noninfectious Causes Bite (fight wounds) "Whisker trimming" ("hair nibbling, " "barbering") Diarrhea Bacillus piliformis Citrobacter freundii (13iotype 4280)

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 73 Giardia muris (evidence uncertain' Hepatitis virus, mouse (infant mice) Reovirus-3 (evidence uncertain) Rotavirus, mouse (infant mice) Salmonella enteritidis Spironucleus muris (evidence uncertain) Dyspnea Cilia-associated respiratory bacillus Corynebacterium kutscheri Leukemia virus, murine Mycoplasma pulmonis Sendai virus Streptococcus pneumonias emaciation Lymphocytic choriomeningitis virus Salmonella enteritidis Streptobacillus moniliformis Facial Abscesses Staphylococcus aureus Facial Edema Ectromelia virus Gestation Prolonged Sendai virus Growth Retardation Cilia-associated respiratory bacillus Citrobacterfreundii (Biotype 4280) Hymenolepis nana Kilham rat virus Lymphocytic choriomeningitis virus Mycoplasma pulmonis Reovirus-3 (evidence uncertain) Sendai virus Sialodacryoadenitis virus Head Tilt Mycoplasma pulmonis Pseudomonas aeruginosa Theiler's virus Hemoglobinuria Streptobacillus moniliformis Hunched Posture (See Reluctance to Move) Hyperexcitability Theiler's virus Inapparent Infections (Agents that usually cause subclinical or latent infections under natural conditions) Adenoviruses, mouse Aspicularis tetraptera Bacillus piliformis Corynebacterium kutscheri Cytomegalovirus, mouse Dermatophytes Encephalito oon cuniculi Entamoeba muris Giardia muris Hantaviruses Hepatitis virus, mouse Hymenolepis nana Kilham rat virus Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Mammary tumor virus, mouse Minute virus of mice Rotavirus, mouse Jaundice Hepatitis virus, mouse (athymic mice) Kilham rat virus Reovirus-3 (evidence uncertain) Keratoconus Sialodar~ryoadenitis virus Kyphosis Streptobacillus moniliformis Litter Size Reduced Kilham rat virus

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74 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS Salmonella enteritidis Sendai virus Lymphadenopathy, Peripheral Leukemia viruses, mouse Myobia musculi Myocoptes musculinus Mastitis Pasteurella pneumotropica Ocular Discharge Sialodacryoadenitis virus Pallor (Anemia) Strep to ba c illus mon iliform is Panophthalmitis Pasteurella pneumotropica Papular Rash Ectromelia virus Paralysis of Rear Legs Lactic dehydrogenase-elevating virus (in C58 and AKR mice) Polyomavirus [in athymic (nu/nu) mice] Streptobacillus moniliformis Theiler's virus Photophobia Sialodacryoadenitis virus Streptobacillus moniliformis Pododermatitis Staphylococcus aureus Polypnea Cilia-associated respiratory bacillus Corynebacterium kutscheri Mycoplasma pulmonis Streptococcus pneumoniae Priapism Streptobacillus moniliformis Pruritis Dermatophytes (fungi) Myobia musculi Myocoptes musculinus Staphylococcus aureus Rectal Prolapse Citrobacterfreundii (Biotype 4280) Syphacia spp (evidence uncertain) Reluctance to Move (Animals often sit in hunched posture and have ruffled coats) Bacillus piliformis Ectromelia virus Lymphocytic choriomeningitis virus Mycoplasma pulmonis Salmonella enteritidis Respiratory Rales Cilia-associated respiratory bacillus Corynebacterium kutscheri Mycoplasma pulmonis Streptococcus pneumoniae Ruffled Hair Coat (See Reluctance to Move) Runting (See Wasting Syndrome) Scrotal Cyanosis Kilham rat virus Self-Mutilation of Penis Staphylococcus aureus Skin Ulceration Dermatophytes (fungi) Myobia musculi Myocoptes musculinus Staphylococcus aureus Sneezing Klebsiella pneumoniae

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 75 Mycoplasma pulmonis Sialodacryoadenitis virus Snuffling Cilia-associated respiratory bacillus Mycoplasma pulmonis Sendai virus Sialodacryoadenitis virus Streptococcus pneumonias Stunted Growth (See Growth Retardation) Subcutaneous Mass Mammary tumor virus, mouse Weight Loss Swelling (Edema) Feet and tail Ectromelia virus Ringtail Streptobacillus moniliformis Neck Sialodacryoadenitis virus Swollen, Reddened Joints Corynebacterium kutscheri Mycoplasma arthritidis Strep to bacillus mon ilifo rm is Tremors Theiler's virus Wasting Syndrome Hepatitis virus, mouse [athymic (nu/nu) mice] Polyoma virus [athymic (nu/nu) mice] Citrobacter freundii (Biotype 4280) Corynebacterium kutscheri Hymenolepis nana Kilham rat virus Mycoplasma pulmonis Salmonella enteritidis Sialodacryoadenitis virus Streptococcus pneumonias

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76 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS PATHOLOGY Abscesses Cervical lymph nodes Pasteurella pneumotropica Face, orbits, and tail Staphylococcus aureus Kidney Corynebacterium kutscheri Liver Bacillus piliformis Corynebacterium kutscheri Lung Cilia-associated respiratory bacillus Mycoplasma pulmonis Preputial glands Pasteurella pneumotropica Brain Staphlococcus aureus Mycoplasma arthritidis Mycoplasma pulmonis [athymic (nu/nu) mice] Streptobacillus moniliformis Ascites Encephalitozoon cuniculi Lymphocytic choriomeningitis virus Atelectasis (Lung) Cilia-associated respiratory bacillus Mycoplasma pulmonis Sendai virus Cerebellar hypoplasia Kilham rat virus Age-Dependent Polioencephalomyelitis Choroiditis Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Ependymitis Alopecia (See Dermatitis and Alopecia' Amputations, Necrotic, of Limbs or Tails Corynebacterium kutscheri Ectromelia virus Mycoplasma arthritidis Ringtail Streptobacillus moniliformis Amy loi do s i s Myobia musculi Anemia Leukemia viruses, murine Streptobacillus moniliformis Ankylosis Streptobacillus moniliformis Arthritis Corynebacterium kutscher' Lymphocytic choriomeningitis virus Glial nodules Encephalitozoon cuniculi Hemorrhage Kilham rat virus Intranuclear inclusions Kilham rat virus Leptomeningitis Encephalitozoon cuniculi Lymphocytic choriomeningitis virus Streptococcus pneumoniae Syncytial giant cells Hepatitis virus, mouse Bronchiectasis and Bronchiolectasis Cilia-associated respiratory bacillus Mycoplasma pulmonis Bronchiolar Scarring Cilia-associated respiratory bacillus Sendai virus

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 77 Bronchiolitis Obliterans Cilia-associated respiratory bacillus Cell Fragment Thrombi Salmonella enteritidis Cerebellar Hypoplasia Kilham rat virus Colon and Cecum Cecocolitis Bacillus piliformis Colonic hyperplasia Citrobacter freundii (Biotype 4280) Goblet cell hyperplasia Citrobacter freundii (Biotype 4280) Helminth parasites Aspicularis tetraptera Syphacia spp. Hyperplastic typhlocolitis Hepatitis virus, mouse tathymic (nu/nu) mice] Protozoan parasites Entamoeba muris Tritrichomonas muris Cutaneous Papules, Erosions or Encrustations Ectromelia virus Demyelination and Remyelination Theiler s virus Dermatitis and Alopecia (See Clinical Signs above) Ear Otitis interna Mycoplasma pulmonis Pseudomonas aeruginosa Strep to ba cillus mon iliform is Otitis media Cilia-associated respiratory bacillus Mycoplasma pulmonis Pasteurella pneumotropica Pseudomonas aeruginosa Streptococcus pneumoniae Ectromelia (See Amputations, Necrotic, of Limbs or Tails) Empyema Streptococcus pneumoniae Encephalitis Granulomatous Encephalitozoon cuniculi Hemorrhagic Kilham rat virus Nonsuppurative Hepatitis virus, mouse (See also Polioencephalomyelitis) Encephalomyelitis (See Polioencephalomyelitis) Endometritis Mycoplasma pulmonis Eosinophilic Crystals in Lung Sendai virus Eye (conjunctivitis, corneal ulceration, hyphema, hypopyon, keratitis, keratoconus, lenticular degeneration, megaloglobus, pannus, retinal degeneration, synechia) Sialodacryoadenitis virus Fetal Resorption Kilham rat virus Sendai virus Streptobacillus moniliformis Glial Nodules, Brain Encephalitozoon cuniculi

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78 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS Glomerulonephritis Embolic Corynebacterium kutscher' Immune complex Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Heart Myocarditis Bacillus piliformis Pericarditis Streptococcus pneumonias Hemoglobinuria Streptobacillus moniliformis Hemorrhage Central nervous system, epididymis, and testes Kilham rat virus Jejunum Ectromelia virus Peyers patches Ectromelia virus Hemorrhagic encephalopathy Kilham rat virus Hepatic Necrosis Bacillus piliformis Corynebacterium kutscheri (mice) Hepatitis virus, mouse Kilham rat virus Lymphocytic choriomeningitis virus Mousepox virus Reovirus-3 (evidence uncertain) Salmonella enteritidis Strep to ba cillus mon iliform is Hepatitis, Bacterial Streptococcus pneumonias Hypersensitivity, Cutaneous Myobia musculi Myocoptes musculinus Staphylococcus aureus Immune Complex Glomerulonephritis Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Inclusions Intracytoplasmic (skin) Ectromelia virus Intracytoplasmic and intranuclear (bronchi, ureters, and renal pelvis) Polyoma virus [athymic (nu/nu) mice] Intranuclear Harderian gland Sialodacryoadenitis virus Intestinal mucosa Adenovirus, mouse (MAd-2) Salivary gland Cytomegalovirus, mouse Thymus Thymic virus, mouse Infarcts Central nervous system, epididymis, and testes Kilham rat virus Spleen and testes Streptococcus pneumoniae Intestine, Small Blunting of villi Bacillus piliformis Hepatitis virus, mouse Rotavirus, mouse Enteritis Adenovirus, mouse (MAd-2) Bacillus piliformis Giardia muris . . . Hepat~t~s v~rus, mouse Hymenolepis nana Reovirus-3 (evidence uncertain) Salmonella enteritidis

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 79 Spironucleus muris Enteritis with ulceration Hepatitis virus, mouse Enteritis with ulceration and hemorrhage Bacillus piliformis Citrobacter freundii (Biotype 4280) Ectromelia virus Helminth parasite Hymenolepis nana Ileocecocolitis Bacillus piliformis Citrobacter freundii (Biotype 4280) Salmonella enteritidis Protozoan parasites Giardia muris Spironucleus muris Syncytial epithelial giant cells Hepatitis virus, mouse Keratitis Sialoacryoadenitis virus Kidney Cortical pitting and scarring Encephalitozoon cuniculi Nephritis Corynebacterium kutscheri Encephalitozoon cuniculi Protozoan parasite Encephalitozoon cuniculi Lacrimal Glands (dacryoadenitis, . . . . ntranuclear Inclusions, necrosis, squamous metaplasia) Sialodacryoadenitis virus . . Laryngitis Cilia-associated respiratory bacillus Mycoplasma pulmonis Leukemia and Lymphomas . . . Leukemia viruses, Duane Liver Biliary hyperplasia Kilham rat virus Intranuclear inclusions Kilham rat virus Inflammation, pyogranulomatous Salmonella enteritidis Necrosis Bacillus piliformis Corynebacterium kutscheri Ectromelia virus Hepatitis virus, mouse Kilham rat virus Lymphocytic choriomeningitis virus Salmonella enteritidis Streptobacillus moniliformis Streptococcus pneumonias Thrombi Salmonella enteritidis Lungs Abscesses Cilia-associated respiratory bacillus Corynebacterium kutscheri Mycoplasma pulmonis Atelectasis Cilia-associated respiratory bacillus Mycoplasma pulmonis Sendai virus Bronchiectasis and bronchiolectasis Cilia-associated respiratory bacillus Mycoplasma pulmonis Bronchiolitis, necrotizing, and granulomatous Cilia-associated respiratory bacillus Bronchiolitis obliterans Cilia-associated respiratory bacillus Bronchitis Cilia-associated respiratory bacillus Mycoplasma pulmonis Sendai virus Streptococcus pneumonias Peribronchial and perivascular

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80 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS lymphocyte cuffing Mycoplasma pulmonis Pneumonia (see Pneumonia) Squamoid change (peribronchiolar adematoid hyperplasia or alveolar bronchiolization) Sendai virus Lymphadenopathy Generalized Leukemia virus, murine Streptobacillus moniliformis Mesenteric Bacillus piliformis Peripheral ~ . . . LeuKemla virus, murlne Myobia musculi Myocoptes musculinus Lymph Nodes Abscesses Pasteurella pneumotropica Hyperplasia Bacillus piliformis Lymphocytic choriomeningitis virus Myobia musculi Myocoptes musculinus Salmonella enteritidis Necrosis Ectromelia virus Lymphocytopenia Lactic dehydrogenase-elevating virus Pericarditis Mammary Adenocarcinoma and Carcinosarcoma Mammary tumor virus, mouse Mastitis Pasteurella pneumotropica Me d i as tin i ti s Streptococcus pneumoniae Megaloileitis in Rats Bacillus piliformis Meningitis, Suppurative Streptococcus pneumoniae Meningoencephalitis Encephalitozoon cuniculi Lymphocytic choriomeningitis virus Necrotizing Tracheitis, Bronchitis, and Bronchiolitis Sendai virus Neoplasia Leukemias and lymphomas Leukemia viruses, murine Mammary glands Mammary tumor virus, mouse Salviary glands (also kidney, subcutis, mammary gland, adrenal, bone, cartiliage, blood vessels, and thyroid) Polyoma virus (experimental) Orchitis, Suppurative Streptococcus pneumoniae Ovary, Perioophoritis, Purulent Mycoplasma pulmonis Peribronchiolar Adenomatous Hyperplasia (synonym: adenomatous change, alveolar bronchiolization) Sendai virus Streptococcus pneumoniae Perioophoritis Mycoplasma pulmonis Peritonitis Corynebacterium kutcheri Salmonella enteritidis Streptococcus pneumoniae

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DIAGNOSIS AND RESEARCH COMPfICATIONS OF INFECTIOUS AGENTS 8 Pleuritis Corynebacterium kutscheri Streptococcus pneumoniae Pleural Effusion, Serous Sendai virus Pneumonia Bronchopneumonia Cilia-associated respiratory bacillus Mycoplasma pulmonis Streptococcus pneumoniae Embolic Corynebacterium kutscherz Interstitial Hepatitis virus, mouse Pneumocystis carinii Pneumonia virus of mice, (experimental) Sendai virus Sialodacryoadenitis virus Lobar Streptococcus pneumoniae Necropurulent Corynebacterium kutscheri Unspecified type Streptococcus pyogenes Pododermatitis, Traumatic Staphylococcus aureus Polioencephalomyelitis Lactic dehydrogenase-elevating virus (C58 and AKR mice) Polyoma virus [athymic (nu/nu) . mice] Theiler's virus Polyarthritis Mycoplasma arthritidis Pox Ectromelia virus Preputial Gland Abscesses Staphylococcus aureus Pasteurella pneumontropica Pseudotuberculosis Corynebacterium kutscheri Pyometra Mycoplasma pulmonis Rhinitis Cilia-associated respiratory bacillus Corynebacterium kutscheri Mycoplasma pulmonis Sendai virus Sialodacryoadenitis virus Streptococcus pneumoniae Salivary Glands Intranuclear inclusions Cytomegalovirus, mouse Necrosis Sialodacryoadenitis virus Neoplasms Polyomavirus Sialodenitis Sialodacryoadenitis virus Salpingitis Mycoplasma pulmonis Scrotal Hemorrhage Kilham rat virus Septicemia Bacillus piliformis Corynebacterium kutscheri Salmonella enteritidis Streptobacillus moniliformis Streptococcus pneumoniae Skin Ectoparasites Myobia musculi

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82 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS Myocoptes musculinus Radfordza affinis Papules Ectromelia virus Pox Ectromelia virus Spinal Cord Hemorrhage Kilham rat virus Spleen Infarction Streptococcus pneumonias Necrosis, Diffuse Ectromelia virus Necrosis, Multifocal Ectromelia virus Salmonella enteritidis Streptobacillus moniliformis Thrombi Salmonella enteritidis Streptococcus pneumonias Splenitis Acute bacterial Streptococcus pneumonias Pyogranulomatous Salmonella enteritidis Splenomegaly Corynebacterium kutscheri Ectromelia virus Hepatitis virus, mouse Lymphocytic choriomeningitis virus Myobia musculi Myocoptes musculinus Salmonella enteritidis Streptobacillus moniliformis Streptococcus pneumonias Synctial Giant Cells Brain Hepatitis virus, mouse Bronchial epithelium Mycoplasma pulmonis (mouse) Sendai virus Intestinal epithelium Hepatitis virus, mouse Multiple organs Hepatitis virus, mouse [athymic (nu/nu) mice] Nasal epithelium Mycoplasma pulmonis (mouse) Teratogenic Effects Kilham rat virus Testes Hemorrhage Kilham rat virus Infarction Kilham rat virus Streptococcus pneumonias Thrombocytopenia Cytomegalovirus, mouse Thrombosis Central nervous system, epididymis, and testes Kilham rat virus Liver and spleen Salmonella enteritidis Spleen and testes Streptococcus pneumonias Thymus Enlargement Leukemia viruses, murine Necrosis Ectromelia virus Lactic dehydrogenase-elevating virus Sialodacryoadenitis virus rT'1 . . ~ nym~c virus, mouse Tracheitis Cilia-associated respiratory bacillus

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 83 Corynebacterium kutscheri Mycoplasma pulmonis Sendai virus Sialodacryoadenitis virus Streptococcus pneumonias Typhlocolitis Hepatitis virus, mouse pathymic (nu/nu) mice] Ulcerative Cecitis in Rats Salmonella enteritidis Ulcerative Dermatitis Myobia musculi Uterus Myocoptes musculinus Staphylococcus aureus Endometritis Mycoplasma pulmonis Fetal resorption Kilham rat virus Sendai virus Streptobacillus piliformis Pyometra Mycoplasma pulmonis

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84 COMPANION GUIDE TO INFECTIOUS DISEASES OF MICE AND RATS RESEARCH COMPLICATIONS Altered Immune Response Cytomegalovirus, mouse Ectromelia virus Encephalitozoon cuniculi Giardia muris Hepatitis virus, mouse Kilham rat virus Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Minute virus of mice Mycoplasma pulmonis Myobia musculi Myocoptes musculinus Salmonella enteritidis Sendai virus Spironucleus muris Syphacia spp. Thymic virus, mouse Altered Physiologic, Pharmacologic, or Toxicologic Response Bacillus piliformis Hepatitis virus, mouse Kilham rat virus Lactic dehydrogenase-elevating virus Mycoplasma pulmonis Salmonella enteritidis Streptococcus pneumonias Altered Susceptibility to Other Infections Cytomegalovirus, mouse Encephalitozoon cuniculi . . . Hepatitis virus, mouse Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Mycoplasma pulmonis Rotavirus, mouse Salmonella enteritidis Sendai virus Sialodacryoadenitis virus Carcinogenesis or Spontaneous Neoplasia Citrobacter freundii (Biotype 4280) H-1 virus Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Mammary tumor virus, mouse Mycoplasma pulmonis Polyoma virus Sendai virus Contamination of Cell Cultures Kilham rat virus Lymphocytic choriomeningitis virus Minute virus of mice Mycoplasma arthritidis Mycoplasma pulmonis Polyoma virus Reovirus-3 Contamination of Transplantable Tumors and Altered Host Response Encephalitozoon cuniculi H-1 virus Kilham rat virus Lactic dehydrogenase-elevating virus Lymphocytic choriomeningitis virus Minute virus of mice Mycoplasma arthritidis Mycoplasma pulmonis Polyoma virus Reovirus-3 Sendai virus Inapparent Infection Exacerbated by Experimental Immunosuppression Bacillus piliformis Corynebacterium kutscheri Ectromelia virus Giardia muris Hepatitis virus, mouse

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DIAGNOSIS AND RESEARCH COMPLICATIONS OF INFECTIOUS AGENTS 85 Kilham rat virus Mycoplasma pulmonis Pneumocystis carinii Pseudomonas aeruginosa Salmonella enteritidis Spironucleus muris Zoonotic Agents (Infectious for Humans) Dermatophytes (fungi) Hantaviruses Hymenolepis nana Lymphocytic choriomeningitis virus Salmonella enteritidis Streptobacillus moniliformis Streptococcus pneumonias

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