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Index A Abdomen abdominal breathing, 54 enlargement, 28, 44,71 legions, 54 Abortions and stillbirths, 53, 71 Abscesses, 12, 14, 17, 25, 38,52,53, 71,73,76 Adenoviruses, 9-10 Age factors bacterial infections, 10, 13 viral infections, 22,30, 44, 48,76 Agents (characterization), see Bact- erial infections: agent character- ization; Viral agents; Zoonotic agents Airflow systems, 41 Alopecia, see Dermatitis and alopecia Amputations, 71, 76 Amyloidosis, 59, 76 Anemia, 23,53,76 Ankylosis, 53, 76 Anorexia, 15,71 Arthritis, 35, 37,53,54, 76 Ascites, 30,76 87 Aspicularis tetraptera, 61 Ataxia, 71 Atelectasis, 12, 48, 76 Athymic (nulnu) mice, immune re- sponse,10,15,22,23,30-31,36, 39,40,41,48,52,62,63,65,66,71 B Bacillus piliformis, 10-12 Bacterial infections age factors, 10, 13 agent characterization, 1,4, 10, 12, 13,38, 42, 45,51,53,54 arthritis, 35, 37,53, 54,76 barrier systems, l 1, 13,14, 36, 53, 54 bronchiectasis and bronchiolectasis, 12,36 . . , carc~nogenes~s/spontaneous neoplasia, 11,37 cell/tissue cultures, 35, 37, 46,52 cesarean control, 11, 12, 13, 14, 15, 36,37,38,43,47,53,54 clinical signs, 10, 12, 13, 14-15,35, 36, 38,41,42,45-46,52,54 colon and cecum, 10, 11, 14, 46

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88 INDEX control techniques, general, 13, 37, 38,47,52,53,54 diagnosis, general, 11, 13, 14, 15, 35, 36-37,38,41~2, 46, 51 digestive system, 42-43, 45-46, 52 ectoparasites, secondary infection, 59 ELISA, 13, 15, 35, 37, 38 epizootiology, 10, 13, 14, 36, 38, 42,45,52,53,54 eyes, 11 hyperplasia, 14, 36 immune response, 10, 14,36,42,43 intestines, 10, 13, 38, 47 liver, 10, 11, 15, 46, 47, 53 lymph nodes, 11, 14, 46 mortality, 10, 13, 37, 42, 43, 53 pathology, general, 10, 13-14, 15, 36,38,42,46,52,53,54 reluctance to move, 11, 14, 45,54 research complications, general, 11, 13, 14, 15, 35, 36,43,47, 52, 53,54 respiratory, 12, 14, 15, 36-37, 38, 53, 54 skin and joints, 38, 52, 53 stain techniques, 11, 12, 13 subclinical, 10, 11, 14, 15, 35, 36, 37,38,42,53,54 tumors/transplants, 35, 37 weight loss, 13,14, 36, 45~6, 53, 54 X irradiation, 42, 43 zoonotic, 42, 45, 47, 51, 53, 54 see also specific agents Bamer techniques bacterial infections, 11, 13, 14, 36, 53,54 fungi, 57, 58 parasites, 59, 63, 64 viral infections, 17, 22, 31, 33, 40, 44,51,55 Behavioral trauma, 59 chattering (mice), 36, 48, 71 circling and rolling, 42, 55, 71 head tilt, 11, 36, 73 hyperexcitability, 55, 73 reluctance to move, 11, 14, 30, 45, 54, 74 self-mutilation, 52,74 Brain, 19, 22, 42, 76, 77 Breeding, 2, 23, 49, 51 see also Cesarean derivation Bronchiectasis and bronchiolectasis,76 bacterial infections, 12, 36 viral infections, 48 C Carcinogenesis/spontaneous neoplasia, 84 bacterial infections, 11, 37 leukemia, 28-29, 79 mammary glands, 28, 32-33 Cell/tissue cultures, 4, 84 bacteria, 35, 37, 46, 52 viruses, 9, 51 Cervical edema, 50, 71 Cesarean derivation, 2 bacterial infections, 11, 12, 13, 14, 15,36,37,38,43,47,53,54 fungi, 57 parasites, 59, 63, 64, 67 viral infections, 9, 18, 22, 25-26, 34,40,41,44,49,56 Chattering (mice), 36, 48, 71 Cilia-associated respiratory bacillus (CAR), 12-13, 36 Circling and rolling, 42, 55, 71 Citrobacterfreundii, 13-14 Clinical signs, 71-75 bacterial infections, 10,12,13,1= 15, 35,36, 38,41,42, 45~6,52,54 fungi, 57-58 parasites, 59, 62, 64, 65, 67 viral infections, 17, 24-33, 40, 41, 44,48,50,55 Colon and cecum, 77

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INDEX 89 bacterial infections, 10, 11, 14, 46 parasites, 66, 67, 68 viral infections, 44, 48 Complement fixation (CF), 3 bacterial infections, 11 viral infections, 44, 55 Conjunctivitis, 38, 46, 50, 53, 71-72 Control techniques airflow systems, 41 bacterial infections, 13, 37, 38, 47, 52,53,54 fungi, 57-58 gnotobiotic animal and methods, 39,43 parasites, 59, 63, 64, 66, 67, 68 pathogen-free animals, 2, 27 protozoa, 19, 39, 66, 67, 68 vaccination, 17, 49 viral infections, 16, 17-18, 21, 22, 24,25-26,27,31,33,34,41, 48,49,51,56 see also Barrier techniques; Cesarean derivation; Specific pathogen-free animals Convulsions, 55,72 Corneal ulceration, 72 Corynebacterium kutscheri, 14-15, 53 Cyanosis, 53, 72 Cytomegalovirus, 15-16 D Dacryoadenitis, 38 Deaths, high and low mortality, 72 bacterial infections, 10, 13, 37, 42, 43,53 parasites, 64 viral infections, 17, 30, 55 Dehydration, see Diarrhea Demyelination and remyelination, 77 Dermatitis and alopecia, 52, 59, 71, 72, 76 pododerrnatitis, 74, 81 Dermatophytes, 57-58 Diabetes, 31 Diagnosis, 3, 4, 70-83 bacterial infections, 11, 13, 14, 15, 35, 36-37, 38, 41~2, 46, 51 DNA probes, 13 fungi, 57-58 laboratories for, 6-7 parasites, 59, 62, 63, 64, 65, 67, 68 protozoa, 19, 39, 65-66, 67, 68 stain techniques, 11, 12, 13, 39 viral infections, 9, 16, 17, 21, 22, 25,27,29,31,33,34,40,41, 43-44, 44~5, 48-49,51,56,57 see also Cell/tissue cultures; Clinical signs; Pathology; Serologic tests Diarrhea, 44,46, 53, 72, 73 Digestive system infections bacterial agents, 42~3, 45-46, 52 parasites, 62, 63, 64, 65, 66, 67 viral agents, 22 see also Intestines; specific agents and organs DNA probes, 13 DNA viruses (agent characterization) 9, 15, 16,24,25,33,41 see also specific agents Dyspnea, 14, 54, 73 J' E Ear pathologies, 77 otitis media, 36, 38, 42, 77 Ectoparasites, 58-60 Ectromelia virus, 16-18,53 Empyema, 54, 77 Encephalitis, 19, 77 Encephalitozoon cuniculi, 18-20 Encephalomyelitis, 28, 55-56, 77, 81 Endoparasites, 61-69 Entamoeba muris, 61-62 Enzyme-linked immunosorbent assay (ELISA), 3-4 bacterial infections, 13,15, 35, 37, 38

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90 INDEX viral infections, 9, 16, 17, 21, 22, 24, 25, 31, 34, 40, 41, 43, 44, 48~9, 51, 56, 57 Eosinophilic crystals in lung, 77 Epizootiology bacterial infections, 10, 13, 14, 36, 38,42,45,52,53,54 fungi, 57 parasites, 59, 61,62,64, 65, 67, 68 protozoa, 19, 39, 65, 67, 68 viral infections, 9, 15-17, 20, 22, 24,25,26,28,30,32,33,40, 41,43,44,46,50,55,57 Escherichia coli, 9 Eyes, 77 bacterial infections, 11 conjunctivitis, 38, 46, 50, 53, 71-72 lacrimal glands, 50, 51, 79 F Fungi, 39-40, 57-58, 59 Fur, see Hair G Germfree animal, see Pathogen-free animal Giardia muris, 62-64 Gnotobiotic animal and methods, 39, 43 Growth retardation, 64, 73 H H-1 virus, 24-25 Hair, 52, 57, 58 mites, 58-60 ruffled, 17, 36, 45, 74 Hantaviruses, 20-21 Head tilt, 11, 36, 73 Heart, 10, 78 Hemagglutination inhibition test (EIAI),3,4,17,21,24,25,41,56 Hemoglobinuria, 53, 73 Hemorrhages, 20, 25, 78 Hepatic system, see Liver Hepatitis, 54, 78 Hepatitis virus, 21-24, 63, 66 Herpesviruses, 56-57 Hosts bacterial infection, 52 viral infection, 20 see also Transplants, tissues and organs; Zoonotic agents Hunched posture, see Reluctance to move Hymenolepis nana, 6~65 Hyperexcitability, 55, 73 Hyperplasia bacterial infections, 14, 36 ectoparasites, 59 viral infections, 30 Hypersensitivity, cutaneous, 78 I Immune response, 39, 84-85 athymic (nulnu) mice, 10, 15, 22, 23, 30~31, 36, 39, 40, 41, 48, 52,62,63,65,66,71 bacterial infections, 10, 14, 36, 42,43 parasites, 62, 63, 65 viral infections, 15, 17, 22, 23, 26, 27,30,31,33,40,41,49 see also Serologic tests Inapparent infections, see Subclinical . . . Infections Inclusions, 78 Indirect immunofluorescent antibody test (IFA), 3 bacterial infections, 11, 12 protozoa, 19, 39 viral infections, 9, 16, 21, 22, 25, 31,34,44,51,57 Infarcts, 78 Intestines, 78-79 bacterial infections, 10, 13, 38, 47 parasites, 62, 63, 64, 65, 66 viral infections, 9, 22, 44, 55

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INDEX 9 1 J Jaundice, 73 Joints, see Skin and joints K Keratitis, 79 Keratoconus, 50, 73 Kidneys, 9, 15, 20, 43, 44, 79 Kilham rat virus, 25-26 Kyphosis, 53, 73 L Lacrimal glands, 50, 51, 79 Lactic dehydrogenase-elevating virus, 26-28 Laryngitis, 36, 79 Leukemia, 28-29, 79 Life cycles, parasites, 58-59, 61, 62, 64,65,66,67 Litter size reduced, 74 Liver, 79 bacterial infections, 10, 11, 15, 46, 47,53 hepatitis, 21-24, 54 jaundice, 73 parasites, 64 viral infections, 9, 17, 21-24, 25, 30,54,63,66 Lung pathology, 39, 77, 79-80 bacterial infections, 12, 15 eosinophilic crystals, 77 parasites, 64 pneumonia, 5, 38~1, 48, 54-55, 81 viral infection, 20, 21, 48, 51 Lymph nodes, 80 bacterial infections, 11,14, 46 parasites, 59, 64 viral infections, 17, 5~51, 55, 57 Lymphadenopathy, 53, 74, 80 Lymphocytic choriomeningitis virus, 30~32 Lymphocytopenia, 80 M Mammary tumors, 28, 32-33, 80 Mastitis, 38, 74, 80 Microscopic procedures, 4, 59 Microsporum spp., 57-58 Minute virus of mice, 33-34 Mites, 58-60 Monitoring and monitored animals, 2, 3-6 Mouse hepatitis virus, 21-24, 63, 66 Mouse mammary tumor virus, 32-33 Mouse minute virus, 33-34 Mouse rotavirus, 44 45 Mouse thymic virus, 56-57 Murine respiratory mycoplasmosis (MRM), 36-38 Mycoplasma arthritidis, 35 Mycoplasma musculinus, 60 Mycoplasma pulmonis, 36-38 Myobia musculus, 60 Myocoptes masculines, 59 N Neoplasia, 27-28, 80 leukemia, 28-29, 79 mammary glands, 28, 32-33 see also Carcinogenesis/spontane- ous neoplasia o Otitis media, 36, 38, 42, 77 p Pallor, see Anemia Panophthalmitis, 38, 74 Paralysis, 42, 53, 74 Parasitic infections, 19, 55 barrier techniques, 59, 63, 64 cesarean derivation, 59, 63, 64, 67 clinical signs, general, 59, 62, 64, 65, 67 colon and cecum, 66, 67, 68 control techniques, 59, 63, 64, 66, 67,68

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92 INDEX diagnosis, 59, 62, 63, 64, 65, 67, 68 digestive system, 62, 63, 64, 65, 66, 67 ectoparasites, 58-60 endoparasites, 61-69 epizootiology, 59, 61, 62, 64, 65, 67,68 immune response, 62, 63, 65 intestinal, 62, 63, 64, 65, 66 lymph nodes, 59, 64 pathology, general, 59, 60, 62-63, 64,65,67,68 research complications, 59, 60, 63, 64,66,67,68 respiratory system, 36, 64 skin and joints, 59~0 subclinical infections, 62, 64, 67 weight loss, 62, 64 X irradiation, 65, 66 zoonotic, 62, 64 see also Life cycles, parasites; Protozoa Pasteurella pneumotropica, 38-39 Pathogen-free animals, 2, 27 gnotobiotic animal and methods, 39,43 see also Specific pathogen-free animals Pathology, 76-83 bacterial infections, 10, 13-14, 15, 36, 38, 42, 46,52, 53,54 fungi, 57-58 parasites, 59, 60, 62-63, 64, 65, 67, 68 protozoa, 19, 39, 65, 67, 68 viral infections, 9, 16, 17, 21, 22, 24,25,27,29,30-31,32-33, 40, 41, 44, 48, 50-51,55 see also Clinical signs; specific organs and systems Peritonitis, 46, $0-81 Photophobia, 50, 53, 74 Pinworm, 61, 66-67 Pleuritis, 54, 81 Pneumocystis carinii, 39-40 Pneumonia, 5, 38-41, 48, 54-55, 81 Pneumonia virus of mice, 5, 40~1 Pododermatitis, 74, 81 Polioencephalomyelitis, see Encepha- lomyelitis Polyoma virus, 41-42 Polypnea, 36,74 Poxviruses, 81 Preputial gland abscesses, 52, 81 Priapism, 53, 74 Protozoa, 18-20, 39-40, 65, 67-68 Pruritis, 59, 74 Pseudomonas aeruginosa, 42-43 Pseudotuberculosis, 81 R Radfordia aJ7:inis, 60 Radioimmunoassays, 44 Rectal prolapse, 13, 74 Reluctance to move, 74 bacterial infections, 11, 14, 45, 54 viral infections, 30 Reovirus-3, 43-44 Research complications, 70, 84-85 bacterial infections, 11, 13, 14, 15, 35,36,43,47,52,53,54 parasites, 59, 60, 63, 64, 66, 67, 68 protozoa, 19, 39, 66, 67, 68 viral infections, 9, 18, 23, 24, 26, 27-28,29,31, 33,34, 41~2, 44,49,51,56,57 see also Zoonotic agents Respiratory rates, 14, 36, 74 Respiratory system, 39-40 bacterial infections, 12, 14, 15, 36- 37,38,53,54 bronchiectasis and bronchio- lectasis, 12, 36, 48, 76 dyspnea, 14, 54,73 parasites, 36, 64 sneezing, 50, 74

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INDEX 93 snuffling, 36, 54,74 tracheitis, 83 viral infections,21,22,47-48,51,55 see also Lungs Rhinitis, 36, 54, 81 RNA viruses (agent characterization), 20,21,26,28,30,32,40,43, 44,47,50,55 see also specific agents Rolling, see Circling and rolling Rotavirus, 44-45 Runting, see Wasting syndrome S Salivary glands and saliva, 81 viral infections, 15, 16, 28,41, 50, 51,56,57 Salmonella enteritidis, 5, 45~7,53 Salpingitis, 81 Sampling, 4-6 Scrotal cyanosis, 74 Scrotal hemorrhage, 81 Self-mutilation, 52, 74 Sendai virus, 5, 36, 47-50 Sentinel animals, 6, 23 Septicemia, 15, 42,43,53, 54, 81 Serologic tests, 3-4, 19,46, 56, 59 hemagglutination inhibition test i] (HAI), 3, 4, 17, 21, 24, 25, 41,56 ndirect immunofluores cent anti - body test (IFA),3, 9, 11, 12, 16, 21, 19,39,22,25,31,34,44, 51,57 see also Enzyme-linked immuno- sorbent assay Sialodacryoadenitis virus,36,50-51 Silver stain, see Stain techniques Skin and joints, 75, 82 arthritis, 35, 37,53, 54, 76 bacterial agents, 38,52, 53 fungi, 57-58 hypersensitivity, 78 parasites, 59-60 viral agents, 15, 16-18 see also Dermatitis and alopecia Sneezing, 50, 74 Snuffling, 36, 54, 74 Social behavior, see Behavioral trauma Specific pathogen-free animals, 2, 47 viruses,21,25,27,33,34,49,51,56 Spinal cord, 82 Spironucleus muris, 65-66 Spleen, 17,46,53,54,57,59,66,82 Stain techniques, 39 bacterial infections, 11, 12, 13 Standards, 2,3 Staphylococcus aureus, 51-53,59 Streptobacillus moniliformis, 53-54 Streptococcus pneumonias, 54-55 Subclinical infections, 4,5, 39 bacterial, 10, 11, 14, 15, 35, 36, 37, 38,42,53,54 fungi, 57 parasites, 62, 64, 67 viral, 16, 20, 23, 24, 30,34, 40, 43, 55,56 Symptoms, see Clinical signs; specific symptoms Syphacia obvelatalmuris, 66-67 Synctal giant cells, 82 T Teratogenic effects, 82 Testes, 54, 82 Theiler's virus, 55-56 Thrombosis, 82 Thymic virus, 56-57 Thymus, 50-51, 56-57, 82-83 athymic (nulnu) mice, immune response, 10, 15, 22, 23,30-31, 36,39,40,41,48,52,62,63, 65, 66,71 lymphomas, 28, 29 Thyroid gland, 54

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94 INDEX Tissue cultures, see Cell/tissue cultures Tracheitis, 83 Transplants, tissues and organs, 84 bacteria, 35, 37 protozoa, 19 viral infections, 17, 18, 21, 27, 31, 34,41,44 Tremors, 55 Trichomonas muris, 67-68 Trichophyton spp., 57 Tumors, 84 bacteria, 35, 37 protozoa, 19 viral infections, 17, 18, 20, 21, 27, 31, 32, 34, 41, 42, 43 see also Neoplasia Tyzzer's disease, 10, 11, 46 U Uterine pathologies, 38, 48, 83 V Vaccination, 17, 49 Viral agents, 2, 9-10, 15, 56 age factors, 22, 30, 44, 48, 76 barrier techniques, 17, 22, 31, 33, 40,44,51,55 bronchiectasis and bronchio- lectasis, 48 cesarean der~:~at~on, 9, 18, 22, 25- 26, 34, 4O, 41~ 44, 49,56 clinical signs, general, 17, 24-33, 40, 41, 44,48, 50, -55 colon and cecum, 44, 48 complement fixation, 44, 55 control techniques, general, 16, 17- 18,21,22,24,25-26,27,31, 33, 34, 41, 48, 49, 51, 56 culture techniques, 9, 51 diagnosis, 9, 16, 17, 21, 22, 25, 27, 29, 31, 33, 34, 40, 41, 43-44, 44-45,48-49,51,56,57 digestive system, 9, 22, 44, 55 ELISA,9, 16, 17,21,22,24,25, 31, 34, 40, 41, 43, 44, 48-49, 51,56,57 epizootiology, 9, 15-17, 20, 22, 24,25,26,28,30,32,33,40, 41,43,44,46,50,55,57 HAI test, 17, 21, 24, 25, 41, 56 IFA test, 9, 16, 21, 22, 25, 31, 34, 44,51,57 immune response, 15, 17, 22, 23, 26,27,30,31,33,40,41,49 river, 9, 17,21-24,25,30,54,63, 66 lung, 20, 21, 48,51 lymph nodes, 17, 50-51, 55,57 mortality, 17, 30, 55 pathology, general, 9, 16, 17, 21, 22,24,25,27,29,30-31,32 33,40,41,44,48,50-51,55 research complications, 9, 18, 23, 24,26,27-28,29,31,33,34, 41-42,44,49,51,56,57 respiratory system, 21, 22, 47-48, 51,55 salivary glands, 15, 16, 28, 41,50, 51,56,57 skin and joints, 15, 16-18 specific pathogen-free animals, 21, 25,27,33,34,49,51,56 subclinical infections, 16, 20, 23, 24,30,34,40,43,55,56 transplants, 17, 18, 21, 27., 31, 34, 41,44 tumors, 17, 18,20,21,27,31,32, 34,41,42,43 uterine, 48 X irradiation, 17 zoonotic, 20, 21, 30, 31 see also DNA viruses (agent characterization); RNA viruses (agent characterization); specific agents

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INDEX 95 W Wasting syndrome, 30, 40, 42, 48,53, 63, 73, 75 anorexia, 15, 71 see also Weight loss Weight loss, 39, 71, 73, 75 bacterial infections, 13, 14, 36, 45- 46,53,54 parasites, 62, 64 X X-irradiation bacterial infections, 42, 43 parasites, 65, 66 viral infections, 17 z Zoonotic agents, 85 bacteria, 42, 45, 47, 51, 53, 54 parasites, 62, 64 protozoa, 18 viruses, 20, 21, 30, 31