stress. They can produce hemodilution by causing splenic sequestration of red blood cells (Collette and Meriwether, 1965); the effect is especially noted in horses.

Dose Recommendations (Table 6-1)

Under some circumstances, phenothiazine doses that do not produce obvious overt behavioral manifestations (lower than those recommended in Table 6-1) could be used to alter behavioral patterns slightly and should be considered as adjuncts for the treatment of abnormal behaviors.

Phenothiazines are useful in managing postanesthetic emergence delirium, especially after barbiturate anesthesia. A combination of a tranquilizer and an

TABLE 6-1 Doses of Tranquilizers in Various Species

Species

Drug

Dose, mg/kg (Routea)

Reference

Cat

Promazine

2.2–4.4 (iv, im)

Soma, 1971

 

Acetylpromazine

0.03–0.05 (iv, im)

Gleed, 1987

Cattle

Promazine

0.4–1.1 (iv, im)

Soma, 1971

 

Acetylpromazine

0.1 (im)

Gleed, 1987

Dog

Promazine

2.2–4.4 (iv, im)

Soma, 1971

 

Acetylpromazine

0.03–0.05 (iv, im)

Gleed, 1987

Guinea pig

Promazine

0.5–1.0 (im)

CCAC, 1980

Hamster

Promazine

0.5–1.0 (im)

CCAC, 1980

Horse

Promazine

0.44–1.1 (iv, im)

Soma, 1971

 

Acetylpromazine

0.02–0.05 (iv, im)

Gleed, 1987

Mouse

Promazine

5 (ip)

Vanderlip and Gilroy, 1981

 

Acetylpromazine

2–5 (ip)

Flecknell, 1987

Primate

Acetylpromazine

0.2 (im)

Flecknell, 1987

Rabbit

Promazine

1–2 (im)

CCAC, 1980

 

Acetylpromazine

1 (im)

McCormick and Ashworth, 1971

Rat

Promazine

0.5–1.0 (im)

Kruckenberg, 1979

 

Acetylpromazine

1.0 (im)

Flecknell, 1987

Sheep and goat

Promazine

0.44–1.1 (iv, im)

Soma, 1971

 

Acetylpromazine

0.04–0.06 (iv, im)

Soma, 1971

Swine

Acetylpromazine

1.1–2.2 (im)

Benson and Thurman, 1979

a iv = intravenous; im = intramuscular; ip = intraperitoneal.



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