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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine.

This project was supported by the National Center for Research Resources, National Institutes of Health (Grant R24 RR04523-02); American Veterinary Medical Association; Animal and Plant Health Inspection Service, U.S. Department of Agriculture (Grants 12-34-93-0090-IA and 12-34-61-001-GR); Center for Veterinary Medicine, Food and Drug Administration and Animal Welfare Information Service, National Agricultural Library, U.S. Department of Agriculture (Combined Grant 59-32U4-7-125); Association of American Veterinary Medical Colleges; Charles River Laboratories, Inc.; and E. I. du Pont de Nemours & Company. The views, opinions, and findings contained in this report are those of the committee and should not be construed as an official position, policy, or decision of the sponsoring organizations unless so designated by other documentation.

Library of Congress Cataloging-in-Publication Data

Recognition and alleviation of pain and distress in laboratory animals /Committee on Pain and Distress in Laboratory Animal, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.

p. cm.

Includes bibliographical references and index.

ISBN 0-309-04275-5

1. Laboratory animals—Diseases. 2. Pain in animals. 3. Laboratory animals—Effect of stress on. 4. Animal welfare. I. Institute of Laboratory Animal Resources (U.S.). Committee on Pain and Distress in Laboratory Animals.

[DNLM: 1. Animals, Laboratory. 2. Animal Welfare. 3. Pain— prevention & control 4. Stress—veterinary. QY 54 R311]

SF996.5R43 1992

636.088´5—dc20

DNLM/DLC

for Library of Congress 92-8266

CIP

Copyright © 1992 by the National Academy of Sciences

Printed in the United States of America

First Printing, June 1992

Second Printing, January 1993



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