AEGL-2 VALUES

10 min 30 min 1 h 4 h 8 h
5.0 ppm 5.0 ppm 4.0 ppm 2.5 ppm 1.2 ppm
Key reference: NRC (National Research Council). 2001. Standard Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. National Research Council, National Academy Press: Washington, DC.
Test species/Strain/Number: See derivation of AEGL-3
Exposure route/Concentrations/Durations: See derivation of AEGL-3
Effects: See derivation of AEGL-3
End point/Concentration/Rationale: In the absence of chemical-specific data, NRC (2001) recommends taking one-third of AEGL-3 values when there is evidence of a steep concentration-response curve.
Uncertainty factors/Rationale: See derivation of AEGL-3
Modifying factor: See derivation of AEGL-3
Animal-to-human dosimetric adjustment: See derivation of AEGL-3
Time scaling: See derivation of AEGL-3
Data adequacy: Not adequate

AEGL-3 VALUES

10 min 30 min 1 h 4 h 8 h
15 ppm 15 ppm 12 ppm 7.5 ppm 3.7 ppm
Key reference: Greene, E.A., J.L. Colbourn, D. Donati, and M.H. Weeks. 1960. The Inhalation Toxicity of Perchloryl Fluoride. U.S. Army Chemical Research and Development Laboratories Technical Report CRDLR 3010. Army Chemical Center, Edgewood, MD.
Test species/Strain/Number: Male beagle dogs, 2 per group
Exposure route/Concentrations/Durations: Inhalation, 224, 425, or 451 ppm for 4-h.
Effects:
Rat: LC50 = 385 ppm
Mouse: LC50 = 630 ppm
Dogs: 224 ppm, both dogs had cyanosis and hyperpnea; 425 ppm, both dogs had severe cyanosis and hyperpnea; 451 ppm, 1 of 2 dogs moribund
End point/Concentration/Rationale: 224 ppm was highest nonlethal concentration in dogs with no projected mortality in rats and mice.
Uncertainty factors/Rationale:
Total uncertainty factor: 30
Interspecies: 3, because the 4-h concentration at which 1 of 2 dogs were moribund (451 ppm) and the LC50 concentrations for rats (385 ppm) and mice (630 ppm) are within 3-fold of each other, and all species developed similar symptoms (dyspnea and cyanosis).


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