APPENDIX E

SUMMARY OF ACUTE TOXICITY STUDIES WITH BORON TRIFLUORIDE COMPLEXES

TABLE E-1 Acute Toxicity Studies of Boron Trifluoride Complexes

Test Substance Study Design Results References
Boron trifluoride dihydrate Dermal irritation 6 rabbits, 0.5 mL, 24 h, total corrosion Dunn 1980
Eye irritation 6 rabbits, 0.1 mL, corrosive
Oral LD50 Male rats, LD50 = 464 mg/kg; Female rats, LD50 = 282-363 mg/kg Derelanko and Gad 1982
Boron trifluoride dinbutyl ether Primary dermal irritation (PDI) 6 rabbits, PDI = 5.5, corrosive Braun and Killeen 1975a
Acute dermal toxicity Rabbits (2 males, 2 females/group); only 2 groups tested; LD50 = 1-2 g/kg Braun and Killeen 1975b
Eye irritation 6 rabbits, 0.1 mL, corrosive Braun and Killeen 1975c,d
Oral LD50 Rabbits (1 male and 1 female/dose), LD50 = 0.25 g/kg
Oral LD50 Rats (5 males, 5 females/group), LD50 = 0.71 g/kg Braun and Killeen 1975e
Boron trifluoride diethyl ether Primary dermal irritation 6 rabbits, 0.5 mL, corrosive Eibert 1969
Dermal LD50 Rabbits (6 males, 6 females/group, 2 groups), LD50 = 1-2 g/kg
Eye irritation 6 rabbits, 1.1 mL, corrosive
Oral, minimal lethal dose Rabbits (1 male, 1 female/group), 0.32-1.0 g/kg, lethality at 0.32 g/kg
Oral LD50 Rats, 6/group, LD50 = 375 mg/kg
Inhalation screen, 1 h exposure Rats (5 males, 5 females/group), 2.54 mg/L, 3 males and 1 female died, 1-h LC50 ≥2.54 mg/L
Boron trifluoride diethyl etherate Oral Rats (5 males, 5 females/group); male: LD50 >0.28 but <0.56 g/kg; females: 0.30 g/kg Bonnette 2001


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