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RODENTS Footnote symbols are used consistently in this section, as follows: * *.* or indicate companies holding registered trademarks; 11 indicates timed and untimed pregnant females available; and @ are used for footnotes other than those listed above. The terms used in this section are defined in the "Terms and Defin- itions" section and are abbreviated as follows: Microbiological status: C conventionally reared BR barrier reared or specific pathogen free (SPF) Rearing by means other than natural mother: f fostered DF defined flora OF germfree GN gnotobiote fh fostered by hand In the "Mice" section, a letter and two numbers in brackets, e.g., [J72], following an fh subscript indicates the place and year of hysterectomy derivation of the substrain. Surgical modifications available: adr adrenalectomy cas castration hyp hypophysectomy nep unilateral nephrectomy thy ova ovariectomy used: pan pancreatectomy pare parathyroidectomy thr thyroidectomy thymectomy In the outbred "Guinea Pigs" section, the following color codes are A albino 1 C colored

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2 RODENTS In the "Hamsters" section, pathology and life span information has been included in an attempt to make the listings additionally useful for research purposes. OUTBRED STOCK INFORMATION BREED OR STOCK DESIGNATION: "International Standardized Nomenclature for Outbred Stocks of Laboratory Animals," International Committee on Labora- tory Animals (ICLA) Bulletin, No. 30, March 1972, has been used in desig- nating these animals. Copies of this bulletin are available from the Institute of Laboratory Animal Resources (ILAR), 2101 Constitution Avenue, N.W., Washington, D.C. 20418. . Letters preceding the colon designate the supplier/breeder code consisting of a capital and two or three lower case letters. Capital letters following the colon are used by a breeder to identify his stock. Letters in parentheses denote origin of stock. Subscript symbols (shown on previous page) indicate rearing by means other than natural mother. MICROBIOLOGICAL STATUS: Abbreviations have been listed previously. Ex- planations are provided in the "Terms and Definitions" section. COLONY CLOSED 19 the colony. __ Year after which no new animals were introduced into SURGICAL MODIFICATIONS AVAILABLE: Surgical modifications of animals that can be provided by suppliers by arrangement. listed on the previous page. The abbreviations used are CODE: Code designations for suppliers. Names, addresses, and phone num- bers for suppliers are listed in the final section of the book. INBRED STRAIN INFORMATION STRAIN DESIGNATION: The following references have been used in designa- ting strains of inbred mice and inbred rats, respectively: Staats, J. 1976. Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36:4333-4377. Festing, M., and J. Staats. 1973. Standardized nomenclature for inbred strains of rats. Fourth listing. Transplantation 16(3):221-245. 0 The strain designation is given in capital letters followed by a slash.

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3 RODENTS The substrain designation follows the slash and may be given as numbers or as individual or company codes. Numbers are used to denote substrains that were derived from a common strain but separated before the completion of inbreeding. The individual or company code, written as an initial capital letter followed by up to three lower case letters, indicates the name of the person, laboratory, or company holding the strain. Several codes may appear together, indicating the history of the strain when read from left to right. The current holder's code appears last (farthest right) in the line. Abbreviations indicating rearing by means other than natural mother (listed previously) may be included. MICROBIOLOGICAL STATUS: Abbreviations have been listed previously. Ex- planations are provided in the "Terms and Definitions" section. PRESENT F NUMBER: Current generation of inbreeding, either since the animals were acquired by the current supplier, or over the entire history of the strain. SURGICAL MODIFICATIONS AVAILABLE: Surgical modifications of animals that can be provided by suppliers by arrangement. The abbreviations used have been listed previously. CODE: Code designations for suppliers. Names, addresses, and phone num- bers for suppliers are listed in the final section of the book. OTHER RODENTS Rodents other than those commonly used in the laboratory may be found in the section, "Other Vertebrates: Mammals."

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4 RODENTS . . . MONGOLIAN (MON) GERBILS (Meriones unguiculatus) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code Anp:(MON) C __ Anp Chi:(MON) C 64 Chi Haf:(MON) C 67 Haf Has:(MON) C 76 cas, ova, others Has Hul:(MON) C __ Hul Rbc: BROWN BEAUTY(MON) C Rbc Tum:(MON) C 54 Tum Wbs:(MON)[linebred] C 71 Wbs

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5 RODENTS MONGOLIAN (MON) GERBILS (Meriones unguiculatus) Inbred Microbio- Surgical Strain logical Present Modifications Designation Status F Number Available Code MON/Has MON/Tum 32 MONGOLIAN (MON) GERBILS (Meriones unguiculatus) Mutant cas, ova, others Has Tum Microbio- Stock or Surgical Mutant logical Strain On Which Modifications Designation Status It Is Carried Available Code black spot Has:(MON) MON/Has Tum:(MON) Haf:(MON) cas, ova, others Has cas, ova, others Has Tum Haf

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6 RODENTS GU INEA P IGS (cavia porcel l us3 Outbred Microbio- Colony Surgical Stock logical Closed Modifications Desi~nation Status 19-- Available Code DUNKIN-HARTLEY ( DH ) Bil:(DH) C 72 cas, ova Bil Cam:(DH) C 61 cas, ova Cam Dla:(DH)f' BR 75 ova Dla HARTLEY (HA) Anp:(HA) C __ Anp Cam:FCRC(HA) C 62 cas, ova Cam Cam:(HA) C 64 cas, ova Cam Cam: NON-RESPONDERS C 68 cas, ova Cam TO PLL(HA) Cam: RESPONDERS TO C 68 cas, ova Cam PLL(HA) Can:(HA) BR 69 Can Clc:(HA) C __ Clc Crc:(HA) C 62 Crc Crl:COBS@(HA) BR, DF 70 Crl Dsk:(HA) C __ Dsk Elm:(HA) C 69 adr, hyp, ova, Elm thy Fab:(HA)'' C __ cas, ova, others Fab Gin:(HA) C __ Gin COBS~ is a registered trademark of The Charles River Breeding Labor- atories, Inc., Wilmington, Massachusetts. Timed and untimed pregnant females available.

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7 RODENTS GUINEA PIGS (Cavia porcellus) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code HARTLEY (HA) - cont. Mcr:(HA) New:(HA) Old:(HA) Pep:(HA) Roc:(HA) Sim:(HA) Suo:tHA) Swf:(HA) Wbs:(HA)[linebred] SHORTHAIR (SR) Akl:AK(SR) Anp:C(SR) Hla:(HA) BR 68 Hla Ils:(HA) C 65 Ils Kel:(HA) C 74 Kel C C C C C C C C C C C C Cam:MOEN CHASE A(SR) SHORTHAIR (SR)--AMERICAN Chr:AME RICAN C(SR) C Dsk:AMERICAN A(SR) Hul:AMERICAN A(SR) Hul:AMERICAN C(SR) Mcr 76 71 76 71 60 cas, ova New Old Pep Roc Sim Suo Swf Wbs Akl Anp Cam Chr Dsk Hul Hul

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8 RODENTS GUINEA PIGS (Cavia porcell us) Outbred - Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code SHORTHAIR (SR)--AMERICAN - cont. Isa:AMERICAN AtSR) C Isa Isa:AMERICAN C(SR) C __ Isa Pad: AMERICAN C( SR) C __ Pad Ssi:AMERICAN A(SR) C 68 Ssi SHORTHAIR (SR)--ENGLISH Cam: ENGLISH A(SR) C __ cas, ova Cam Cam:ENGLISH C(SR) C -- . cas, ova Cam Dmf: ENGLISH A(SR) C 72 . Dmf Hla:ENGLISH A(SR) C __ Hla Hla:ENGLISH C(SR) C __ Hla Ils:ENGLISH A(SR) C 65 Ils C Ssi:ENGLISH A(SR) Ssi:ENGLISH C(SR) Thr: ENGLISH A(SR) Thr:ENGLISH C(SR) OTHER STOCKS Hul:ABYSSINIAN C Hul:PERWIAN C non-designated C 68 68 Ssi Ssi Thr Thr Hul Hul Drb non-designated C 58 Thr [1inebred-various colors]

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9 RODENTS GUINEA PIGS (Cavia porcellus) Inbred Microbio- Surgical Strain logical Present Modifications Designation Status F Number Available Code WRIGHT STRAIN 2 COBS~2/Crl BR -- Crl 2/Crc C 9 Crc 2/Elm C -- adr, hyp, ova, Elm thy WRIGHT STRAIN 13 COBS@13/Crl BR -- Crl 13/Crc C 51 Crc COBRA is a registered trademark of The Charles River Breeding Labor- atories, Inc., Wilmington, Massachusetts. These guinea pigs now are being outbred, but in 1978 were found to be histocompatible with inbred Strain 2 animals from a number of other sources. GUINEA PIGS (Cavia porce77 us) Partially Inbred Microbio- Number of Stock logical Generations Designation Status of Inbreeding Code Emr:(HA) Emr

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10 RODENTS HAMSTERS Outbred Microbio- Colony Stock logical Closed Designation Status 19-- Comments Code - ARMENIAN OR GREY (ARM) Iebs:(ARM) (Cricetulus migratorius ) C 64 CHINESE OR STRIPED-BACK (CHN) (Cricetulus griseus) prone to autoimmune diseases; free of spontaneous neoplasms; highly sensitive to low doses of chemical car- cinogens; life span 1000 days Iebs Chi:(CHN) C 64 Chi Iebs:(CHN) ~ 67 SYRIAN GOLDEN (SYR) (Mesocricetus auratus) low incidence of span- Iebs taneous neoplasms; model for adjuvant- induced lymphomatoid & sarcomatoid granulo- matosis, sarcoidosis, vasculitis, pancrea- titis, & insulitis; life span 1000 days Anp:(SYR) C __ Anp Bbh:(SYR) [albino] C 77 Bbh Bbh:(SYR) [various C 77 Bbh colors] Chi:(SYR) C 59 Chi Eng:ELA(SYR) BR 68 Eng Haf:(SYR) C 69 Haf Haf:(SYR) [albino] C 65 Haf Haf:(SYR) [black] C 75 Haf

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11 RODENTS HAMSTERS Outbred Microbio-. Colony Stock logical Closed Designation Status 19-- Comments Code SYRIAN GOLDEN ~ SYR) (Mesocricetus auratus) - cont. Lak:LVG(SYR) C 51 surgical modifications: Lak adr, cas, hyp, ova, thy Mcr:(SYR) C __ Mcr Roc:(SYR) C __ Roc Sas:(SYR) C 73 Sas Sch:(SYR) BR 71 Sch Sim:(SYR) C 76 Sim Ssi:(SYR)f [outbred C and linebred] __ Ssi

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30 RODENTS RATS (Rattus norvegicus ) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code BUFFALO ( BUF ) Mlr:(BUF) BR -- HOLTZMAN SPRAGUE-DAWLEY~) H ( SD ) * Crl:COES~CD@H(SD) BR, DF, GF Mlr 75 adr, cas, hyp, Crl ova, thy Hot:H(SD) C __ Hot Sas:H(SD) C 66 Sas LONG EVANS ( LE ) Blu:(LE) BR 64 adr, cas, hyp, Blu ova, thr Can:COBS@(LE) BR 71 adr, cas, hyp, Can ova, thy Haf:(LE) C 70 Haf Mar:MFL(LE) BR 63 adr, cas, hyp, Mar ova, thy, Grollman modification Mlr:(LE) BR -- cas Mlr Pep:(LE) C 65 Pep Roc:(LE) C __ Roc Sim:(LE) BR 49 adr, cas, hyp, Sim ova, pan, thy * Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio. COBS~ and CD~ are registered trademarks of The Charles River Breeding Laboratories, Inc., Wilmington, Massachusetts.

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31 RODENTS RATS (Rattus norvegicus ) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code MUNICH WISTAR MUN(WI) Tex:MUN(WI)~ BR, DF 76 GF, GN OSBORNE MENDEL (OM) Tex Cam: (OM) C 53 adr, cas, hyp, Cam ova, pan, thy, parabiosis Roc: (OM) C __ Roc SHERMAN (SH) BTU: (SH) BR 73 adr, cas, hyp, Blu ova, thr Cam: (SH) C 53 adr, cas, hyp, Cam ova, pan, thy, parabiosis Roc: (SH) C __ Roc SPONTANEOUSLY HYPERTENSIVE (SHR) Tac:N(SHR)f BR -- adr, cas, hyp, Tac ova, pan, thy, others SPRAGUE-DAWLEY(~(SD)* Anp:(SD) C __ Anp Bil: (SD) C 67 cas, ova Bil Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio.

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32 RODENTS RATS (Rattus norvegicus) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code S P RAGU E - DAWL KY(~) ~ SD ~ * - con ~t. Blu:(SD) BR 54 adr, cas, hyp, Blu ova, thr Cam:(SD)f BR, DF 76 adr, cas, hyp, Cam GF, GN ova, pan, thy, parabiosis Can: COBS~CD@(SD) BR 70 adr, cas, hyp, Can ova, thy Crl:COBS~CD~(SD) BR, DF, 50 adr, cas, hyp, Crl GF ova, thy Dub:(SD) C 70 adr, cas, ova, Dub pan, thy Fab:(SD)'' C __ adr, cas, ova Fab Haf:(SD) C 67 Haf Hap:(SD)f BR, DF, 75 adr, cas, hyp, Hap GF, GN nep, ova, pare, tier, thy Hla:(SD) BR 72 Hla Kng:(SD) BR 77 Kng Lai:COX(SD) BR, DF, 67 Lai GF Mac:ML(SD) C 58 Mac * Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio. COBS~ and CD~ are registered trademarks of The Charles River Breeding Laboratories, Inc., Wilmington, Massachusetts. 11 Timed and untimed pregnant females available. Mackesey Laboratories (Mac) accepts standing orders only.

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RODENTS RATS (Rattus norvegicus ) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code SPRAGUE-DAWLEY(~) (SD )* - cont. Mar:MFS(SD)1l BR 77 adr, cas, hyp, Mar ova, thy, Grollman modification Mcr:(SD) C __ Mcr Pep:(SD) C 65 Pep Roc:(SD) C __ Roc Saf:(SD) BR 66 Saf Sas:(SD) DF 79 Sas Sch: SPRAGUE- BR, GF 29 Sch DAWLEY~(SD) Sim:(SD)f BR, DF, 58 adr, cas, hyp, Sim GN ova, pan, thy Spb:(SD) C 63 cas, ova, thy Spb Suo:(SD) C S4 Suo Tac:N(SD)f BR -- adr, cas, hyp, Tac ova, pan, thy, others Tex:(SD)f BR, DF, 69 Tex GF, GN Zml:ZM(SD)f BR 67 adr, cas, hyp, Zml ova, pan, thy, others Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio. . . Timed and untimed pregnant females available. Arrangements can be made for animals to be held up to 24 months of age. Timed pregnant females and animals over 18 months of age available.

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34 RODENTS RATS (Rattus norvegicus) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code ~ _ l~lISTAR (hlI ) Anp:(WI) C __ Anp Cam:(WI) C 64 adr, cas, hyp, Cam ova, pan, thy, parabiosis Can:COBS~(WI) BR 74 adr, cas, hyp, Can ova, pan, thy Crl:COBS@(WI) BR, DF, 75 adr, cas, hyp, Crl GF ova, thy Fab:(WI)'' C __ adr, cas, ova Fab Hap:(WI)f BR, DF, 46 adr, cas, hyp, Hap GF, GN nep, ova, pare, tier, thy Hla:(WI) BR 56 Hla Lai:COX(WI) BR, DF, 69 Lai GF Mar:MFW(WI) 11 BR 72 adr, cas, hyp, Mar ova, thy, Grollman modification Pep:(WI) Roc:(WI) Roy:(WI) 69 Pep Roc Roy Sim:(WI) BR 57 adr, cas, hyp, Sim ova, pan, thy ** fii' COBSV is a registered trademark of The Charles River Breeding Labora- tories, Inc., Wilmington, Massachusetts. ~1 Timed and untimed pregnant females available. Arrangements can be made for animals to be held up to 24 months of age.

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35 RODENTS RATS (Rattus norvegic7~s) Outbred Microbio- Colony Surgical Stock logical Closed Modifications Designation Status 19-- Available Code hlISTAR (WI ) - cont. Wbs:(WI) [linebred] C 74 Wbs WISTAR KYOTO (Lilly ) @ Tac:N(WKY)f BR -- adr, cas, hyp, ova, pan, thy, others @Control animals for Spontaneously Hypertensive (SHR) rats.

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Strain 36 RODENTS RATS (,Rattu5 norvegicusj Partially Inbred Microbio- Number of Surgical Modifications logical Generations Designation Status of Inbreeding Available Code LONG EVANS ( LE ) Mlr:(LE) BR 8 cas Mlr SPRAGUE-DAhlLEY(g) (SD) Mlr:(SD) BR 8 cas Mlr Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio.

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37 RODENTS RATS (Rattus norvegicus) Inbred Microbio- Surgical Strain logical Present Modifications Designation Status F Number Available Code ACI ACI/Sim BRO1~IN NORWAY ( BN ) c ACI/Cox BR, DF, 100 Lai GF ACI/Hapf BR, DF, 5 adr, cas, hyp, Hap GN nep, ova, pare, tier, thy ACI/Maif BR 98 Mai 32 adr, cas, hyp, Sim ova, pan, thy BN/Maif BR 41 Mai BUFFALO ( BUF ) BUF/Cox BR, DF, 96 Lai GF BUF/Maif BR 76 Mai BUF/Sim 47 adr, cas, hyp, Sim ova, pan, thy BUF/Texf BR, DF, 10-15 Tex GF, GN FISCHER 344 (F344) COBS~CDF@F344/Crl BR, DF, 22 adr, cas, hyp, Crl GF ova, thy COBS~ and CDF~ are registered trademarks of The Charles River Breed- ing Laboratories, Inc., Wilmington, Massachusetts.

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38 RODENTS RATS (Rattus norvegicus) Inbred Microbio- Surgical Strain logical Present Modifications Desiqnation Status F Number Available Code FISCHER 344 (F344) - cont. F344/Cox BR, DF, 128 Lai GF F344/Hapf BR, DF, 3 adr, cas, hyp, Hap GF, GN nep, ova, pare, tier, thy F344/Maif BR 112 Mai F344/Sch BR, 26 Sch GF, GN F344/Simf BR 41 adr, cas, hyp, Sim ova, pan, thy GENETICALLY HYPERTENSIVE (GH) GH/Zml BR 20+ adr, cas, hyp, ~ml ova, pan, thy, others LEWIS (LEW) COBS~LEW/Crl BR, DF, 52 adr, cas, hyp, Crl GF ova, thy LEW/Maif BR 79 Mai MAXX MAXX/Maif BR 28 Mai COB S~ is a registered trademark of The Charles River Breeding Labora- tories, Inc., Wilmington, Massachusetts.

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39 RODENTS RATS (Rattus norvegicus) Inbred Microbio- Surgical Strain logical Present Modifications Designation Status F Number Available Code SPONTANEOUSLY HYPERTENSIVE (SHR) COBS@SHR/NCrl BR, DF, adr, cas, hyp, Crl GF ova, thy SHR/Cox BR, DF 41 Lai GF SPRAGUE-DAWLEY~ (SD) MLSI(SD)/Mac C 80 Mac WISTAR FURTH (WF) WF/Maif BR 62 Mai WF/Schf BR, 29 Sch GF, GN WISTAR KYOTO (WKY)@ COBS ~ Y/NCrl BR, DF, adr, cas, hyp, Crl GF ova, thy WKY/Cox BR, DF, 15 Lai GF Sprague-Dawley~ is a registered trademark of The Mogul Corporation, Chagrin Falls, Ohio. COB S~ is a registered trademark of The Charles River Breeding Labora- tories, Inc., Wilmington, Massachusetts. Mackesey Laboratories (Mac) accepts standing orders only . @ Control an~mals for Spontaneously Hypertensive (SHR) rats.

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40 RODENTS RATS (Rattus norvegicus ) Hybri d Hybrid Microbiological Designation Status Parental Strains Code LBNF1 BR LEW/Mai x BN/Mai Mai RATS (Rattus norvegicus ) Mutant Microbio- &rgical logical Modifications Mutant Designation Status Available Code j (Jaundice or Gunn) BR fa (Fatty or Zucker) C di (Diabetes insipidus BR or Brattleboro) GH (Genetically See inbred rat listing. hypertensive) SHR (Spontaneously hypertensive) adr, cas, hyp, Blu ova, thr adr, cas, hyp, Fab pan, thy adr, cas, hyp, Blu ova See inbred and outbred rat listings.