vaccine development, 133, 173–174, 178–179, 182, 183–186, 188, 191–193, 195, 197

vector ingestion of human, 123

see also Immunoassays

Antigens, 95, 99–100

erythrocyte surface, 188

immunoassays, 77–79, 82, 85, 86

liver, 170, 172, 177

neoantigens, 99–100

transmission-blocking vaccines, 194

vaccines, 170, 177–178, 180, 188–189, 191, 194

variation, 102–103

see also Cell-mediated immunity

Antimalarial drugs, see Drugs, antimalarial

Army Medical Research and Development Command, 49, 153

Artemisinin, 148, 155–156, 159, 162

Assays, 73, 77–78, 181, 124, 139

ELISA, 77–78, 80, 81, 127

immunoassays, general, 77–79, 82, 85, 86

in vitro techniques, 45, 66, 96, 109, 122, 138, 155, 158, 170, 173, 198, 229

radioimmunoassays, 78–79

vaccine development, 181

vector studies, 122, 126

Asymptomatic infections, 22, 74, 212–214, 234

Autologous red blood cell agglutination assay, 82

B

B cells, 174, 177, 178

Bacillus thuringiensis israeliensis, 35

Bednets, 35, 130, 131, 132, 223, 228, 235–236

Behavioral factors, 8, 223–224, 226, 257, 264–265, 271–272

clothing, protective, 35

research, 13–14, 258, 271–274

see alsoCultural factors;

Migration;

Social factors;

Travel and tourism

Beta-lactam antibiotics, 156

Biochemistry, general, 90, 107, 163

see also Drugs;

Vaccines

Biological control agents, vectors, 35, 133–134, 229

Board for the Co-ordination of Malaria Studies, 157

BW566c, 160

C

California, 3–4

Cell-mediated immunity, 174–182 passim, 186, 189, 193, 194

immunoglobulin, 123, 179

Centers for Disease Control, 48, 51, 157

Cerebral malaria, 13, 57–61, 23, 65, 265

Children, 4–5, 13, 47, 169, 184, 189, 213, 215, 218, 234

antimalarial drugs, 158, 184, 225

bednets, 228

endemics, 33, 146, 222–223

severe malaria, 58, 61, 62, 66–67, 145–146, 169, 189, 211, 220, 225, 244

China, 155

Chloramphenicol, 156

Chlorguanil, 153

Chloroquine, 3, 4, 5, 35, 45, 60, 64, 107–108, 129, 144, 147, 148, 150–151, 156, 157, 160–161, 267, 268, 269

Chlorproguanil, 153

Chlorpromazine, 161

Chronic complications, 27, 63, 145, 147, 222

Circumsporozoite protein (CS protein), 91, 175–181

Civil War, 39

Classification, see Taxonomy

Climate, 28, 30, 218, 219, 222

see also Seasonal factors

Clindamycin, 156

Clinical factors, 23–24, 57–64

pathogenesis, 13, 65

research, 65



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