West African countries for the spread of chloroquine-resistant P. falciparum malaria. On the basis of data collected through this surveillance system, the dosing regimen for malaria prophylaxis with mefloquine was recently revised (Department of Health and Human Services, 1991). This relatively simple surveillance network has provided up-to-date information on disease risk and should continue to serve as a model for future attempts at collecting relevant, reliable data (Moran and Bernard, 1989).

RESEARCH FOCUS: Expansion of this effort to encourage further development of rational prophylaxis regimens based on operational research and simple surveillance networks.

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Chiodini, P. L., M. Somerville, I. Salam, H. R. Tubbs, M. J. Wood, and C. J. Ellis. 1985. Exchange transfusion in severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 79:865-866.

Cuturi, M. C., M. Murphy, M. P. Costa-Giomi, R. Weinmann, B. Perussia, and G.Trinchieri. 1987. Independent regulation of tumor necrosis factor and lymphokine production by human peripheral blood lymphocytes. Journal of Experimental Medicine 165:1581-1594.

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