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generally, it recognizes, nevertheless, that opportunities may exist for informative experiments in human populations that take advantage of the possibility of using alternative schedules for administration of vaccines.

A careful review is needed to identify what sorts of questions might be best answered by further investigations and which kinds of studies could be carried out economically. The availability and introduction of new forms of pertussis vaccine, for example, could offer valuable opportunities for comparison of vaccine safety as well as efficacy. The committee is not in a position to make specific recommendations, but its experience points to fresh possibilities and to the need for such a review.



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