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his undergraduate and medical education at Vanderbilt University and his postgraduate training at Children's Hospital, Boston, and Harvard Medical School. He has been chairman of the Department of Pediatrics at the National Jewish Center for Immunology and Respiratory Medicine and at the University of Pennsylvania. He is board certified in pediatrics and serves as a clinical immunologist for children. His clinical and research interests center about host defense against infection; his research involves the biochemical basis for the killing of invading microorganisms by phagocytic cells. He presently chairs the Advisory Committee for Vaccines and Related Biological Products for the Food and Drug Administration.

MICHAEL KATZ is Chairman of the Department of Pediatrics at the College of Physicians and Surgeons of Columbia University and Director of Pediatrics at Babies Hospital, a division of the Columbia-Presbyterian Medical Center in New York. He is also the Reuben S. Carpentier Professor of Pediatrics and Professor of Public Health (Tropical Medicine). Dr. Katz has a clinical specialty of infectious diseases and parasitology, and his research interests have dealt with host defense in malnourished children and mechanisms of latent virus infections. He is an author and co-author of original scientific papers dealing with these subjects and, with two colleagues, an author of a textbook on parasitic diseases. Dr. Katz is a member of the Institute of Medicine and a number of professional societies and a recipient of several awards, among them the Humboldt Award for Senior U.S. Scientists, given by the German government. He has been a visiting professor in universities in the United States and abroad. He has been a consultant to the World Health Organization, United Nations International Children's Emergency Fund, and various government organizations.

DARWIN L. LABARTHE is the James W. Rockwell Professor of Public Health in the School of Public Health at The University of Texas Houston Health Science Center. He received an M.D. degree from Columbia University and M.P.H. and Ph.D. degrees in public health and epidemiology from the University of California, Berkeley. He is a member or fellow of the American Heart Association, the Society for Epidemiologic Research, and the American Public Health Association and a diplomate of the American Board of Preventive Medicine. Dr. Labarthe's research interests include epidemiology and prevention, especially of cardiovascular and other chronic conditions among both children and adults; issues in the interpretation of epidemiologic evidence, especially concerning causation; and occupational and other environmental exposures potentially related to cancer.

DAVID A. LANE is a Professor in the Department of Theoretical Statistics at the University of Minnesota. He received an M.S. in mathematics from the University of North Carolina and a Ph.D. in statistics from the