Page 5

TABLE 1-1 Categories of Evidence Reviewed for Each Adverse Event: Is the Evidence Supportive of Causation?a

Vaccine and Adverse Event

Human Experiments

Experiments Animal

Case-Comparison Cohort, and Other Controlled Studies

Case Reports
and Case Series

Biologic Plausibility

(Chapter of Report)

Yesb

?c

Nod

Yes

?

No

Yes

?

No

Yes

?

No

Yes

?

No

DPT

                             

Infantile spasms(4)

               

X

 

X

       

Hypsarrhythmia (4)

   

X

             

X

       

Aseptic meningitis (4)

             

X

   

X

       

Acute encephalopathye(4)

       

X

 

X

   

X

     

X

 

Chronic neurologic damage (4)

       

X

   

X

   

X

   

X

 

Sudden infant death syndrome (5)

               

X

 

X

       

Anaphylaxis (6)

       

X

   

X

 

X

   

X

   

Autism (6)

                             

Erythema multiforme or other rash (6)

                   

X

       

Guillain-Barrè syndrome (polyneuropathy) (6)

                   

X

       

Peripheral mononeuropathy (6)

                   

X

 

X

   

Hemolytic anemia (6)

                   

X

       

Juvenile diabetes (6)

       

X

   

X

   

X

       

Learning disabilities and hyperactivity (6)

               

X

 

X

       

Protracted inconsolable crying and screaming (6)

           

X

   

X

   

X

   

Reye syndrome (6)

             

X

       

X

         

Table continued on next page

 


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