TABLE 1-1 Continued

Vaccine and Adverse Event

Human Experiments

Animal Experiments

Case-Comparison Cohort, and Other Controlled Studies

Case Reports
and Case Series

Biologic Plausibility

(Chapter of Report)

Yesb

?c

Nod

Yes

?

No

Yes

?

No

Yes

?

No

Yes

?

No

Shock and "unusual shock-like state" (6)

X

X

X

Thrombocytopenia (6)

X

RA 27/3 Rubella

Arthritis (7)

Acute

X

X

X

Chronic

X

X

X

X

Radiculoneuritis and other neuropathies (7)

X

X

Thrombocytopenic purpura (7)

X

X

aBlanks for any given category of evidence indicate that evidence of this kind is lacking.

bYes, Evidence of this kind is supportive of causation.

c?, Evidence of this kind cannot be classified either as supportive or as not supportive of causation.

dNo, Evidence of this kind is not supportive of causation. 

eDefined in controlled studies reviewed as encephalopathy, encephalitis, or encephalomyelitis.