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NATIONAL ACADEMY PRESS · 2101 Constitution Avenue, N.W. • Washington, D.C. 20418

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this the Institute acts under the Academy's 1863 congressional charter responsibility to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Samuel O. Thier is President of the Institute of Medicine.

The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NOI-AI-95041).

Library of Congress Cataloging-in-Publication Data

Institute of Medicine (U.S.). Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines.
Adverse effects of pertussis and rubella vaccines : a report of the
Committee to Review the Adverse Consequences of Pertussis and
Rubella Vaccines / Christopher P. Howson, Cynthia J. Howe, and
Harvey V. Fineberg, editors.
p. cm.
Includes bibliographical references and index.
ISBN 0-309-04499-5
1. Pertussis vaccines—Side effects—Congresses. 2. Rubella
vaccines-—Side effects—Congresses. 3. Whooping cough—Preventive
inoculation—Complications and sequelae—Congresses. 4. Rubella—
Preventive inoculation—Complications and sequelae—Congresses.
I. Howson, Christopher Paul. II. Howe, Cynthia J. III. Fineberg,
Harvey V. IV. Title.
[DNLM: 1. Pertussis Vaccine—adverse effects. 2. Rubella Vaccine—
adverse effects. WC 340 159r]
QR 189.5.P46156 1991
615'.372—dc20
DNLM/DLC
for Library of Congress          91-25665
                         CIP

Copyright © 1991 by the National Academy of Sciences

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Printed in the United States of America

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatlichemusseen in Berlin.