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NATIONAL ACADEMY PRESS · 2101 Constitution Avenue,
N.W. • Washington, D.C. 20418
NOTICE: The project that is the subject of this report was
approved by the Governing Board of the National Research Council,
whose members are drawn from the councils of the National Academy
of Sciences, the National Academy of Engineering, and the Institute
of Medicine. The members of the committee responsible for the
report were chosen for their special competences and with regard
for appropriate balance.
This report has been reviewed by a group other than the authors
according to procedures approved by a Report Review Committee
consisting of members of the National Academy of Sciences, the
National Academy of Engineering, and the Institute of Medicine.
The Institute of Medicine was chartered in 1970 by the National
Academy of Sciences to enlist distinguished members of the
appropriate professions in the examination of policy matters
pertaining to the health of the public. In this the Institute acts
under the Academy's 1863 congressional charter responsibility to be
an adviser to the federal government and, upon its own initiative,
to identify issues of medical care, research, and education. Dr.
Samuel O. Thier is President of the Institute of Medicine.
The project was supported by funds coordinated through the
National Institute of Allergy and Infectious Diseases of the
National Institutes of Health (contract no. NOI-AI-95041).
Library of Congress Cataloging-in-Publication Data
Institute of Medicine (U.S.). Committee to Review the Adverse
Consequences of Pertussis and Rubella Vaccines.
Adverse effects of pertussis and rubella vaccines : a report of
Committee to Review the Adverse Consequences of Pertussis and
Rubella Vaccines / Christopher P. Howson, Cynthia J. Howe,
Harvey V. Fineberg, editors.
Includes bibliographical references and index.
1. Pertussis vaccinesSide effectsCongresses. 2.
vaccines-Side effectsCongresses. 3. Whooping
inoculationComplications and sequelaeCongresses. 4.
Preventive inoculationComplications and
I. Howson, Christopher Paul. II. Howe, Cynthia J. III.
Harvey V. IV. Title.
[DNLM: 1. Pertussis Vaccineadverse effects. 2. Rubella
adverse effects. WC 340 159r]
QR 189.5.P46156 1991
for Library of Congress
Copyright © 1991 by the National Academy of
No part of this book may be reproduced by any mechanical,
photographic, or electronic procedure, or in the form of a
phonographic recording, nor may it be stored in a retrieval system,
transmitted, or otherwise copied for public or private use, without
written permission from the publisher, except for the purpose of
official use by the United States government.
Printed in the United States of America
The serpent has been a symbol of long life, healing, and
knowledge among almost all cultures and religions since the
beginning of recorded history. The image adopted as a logotype by
the Institute of Medicine is based on a relief carving from ancient
Greece, now held by the Staatlichemusseen in Berlin.