Appendix B

Substances Evaluated by the Committee to Identify Toxic Substance—Occupational Disease Links Not Found in SEM

The following substances were evaluated by the Institute of Medicine’s Committee on the Review of the Department of Labor’s Site Exposure Matrix (SEM) Database to identify toxic substance—occupational disease links that were not found in SEM (see discussion in Chapter 3).

81 substances (and CAS [Chemical Abstracts Service] numbers) for which public inquiries were made:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/MPTP (28289-54-5)

1,2-Benzisothiazoline-3-one (2634-33-5)

1,3-Butadiene (106-99-0)

1,4-Phenylenediamine (106-50-3)

2-Aminophenol (95-55-6)

2-Butanone/MEK (78-93-3)

2-Naphthylamine (91-59-8)

2,4,6-Trinitrotoluene (118-96-7)

4,4′-Methylenedianiline/MDA (101-77-9)

5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)

Acetic acid (64-19-7)

Acetone (67-64-1)

Aluminum (7429-90-5)

Arsenic (7440-38-2)

Asbestos (1332-21-4)

Benzene (71-43-2)

Beryllium (7440-41-7)



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Appendix B Substances Evaluated by the Committee to Identify Toxic Substance–Occupational Disease Links Not Found in SEM T he following substances were evaluated by the Institute of Medicine’s Committee on the Review of the Department of Labor’s Site Exposure Matrix (SEM) Database to identify toxic substance–occupational disease links that were not found in SEM (see discussion in Chapter 3). 81 substances (and CAS [Chemical Abstracts Service] numbers) for which public inquiries were made: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/MPTP (28289-54-5) 1,2-Benzisothiazoline-3-one (2634-33-5) 1,3-Butadiene (106-99-0) 1,4-Phenylenediamine (106-50-3) 2-Aminophenol (95-55-6) 2-Butanone/MEK (78-93-3) 2-Naphthylamine (91-59-8) 2,4,6-Trinitrotoluene (118-96-7) 4,4´-Methylenedianiline/MDA (101-77-9) 5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4) Acetic acid (64-19-7) Acetone (67-64-1) Aluminum (7429-90-5) Arsenic (7440-38-2) Asbestos (1332-21-4) Benzene (71-43-2) Beryllium (7440-41-7) 117

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118 REVIEW OF THE DOL’S SITE EXPOSURE MATRIX DATABASE Cadmium (7440-43-9) Carbon disulfide (75-15-0) Chromic acid cleaning solution/Chromic sulfuric acid (14489-25-9) Chromium (7440-47-3) Cobalt (7440-48-4) Copper (7440-50-8) Cutting oils/Tap Magic Original Formula Cyanide (57-12-5) Di-2-Ethyl Hexyl Phosphoric Acid (298-07-7) Edetic acid/Versene (60-00-4) Engine exhaust Epoxy resins/Bisphenol A diglycidylether (1675-54-3) Ether/Diethyl ether (60-29-7) Euxenite Fiberglass/Borosilicate (12676-29-8) Formaldehyde (50-00-0) Hard metals/Stainless steel (7440-44-0; 7440-47-3; 7439-89-6; 7439-98-7; 7440-02-0; 7440-03-1; 7440-32-6) Hexane/n-Hexane (110-54-3) Hydrogen Fluoride/Hydrofluoric acid (7664-39-3) Iodine 131 (10043-66-0) Isodecanol (25339-17-7) Kerosene (8008-20-6) Lead (7439-92-1) Lead chromate (7758-97-6) Lithium deuteride (13587-16-1) Lithium hydride (7580-67-8) Maneb (12427-38-2) Mercury (7439-97-6) Metal Working Fluids/Mineral Oil (8020-83-5) Methylene bisphenyl diisocyanate/MDI (101-68-8) Methylene Chloride/Dichloromethane (75-09-2) Monel/nickel alloys (11105-19-4) Naphthalene (91-20-3) Nickel (metal dusts) (7440-02-0) Niobium (7440-03-1) Nitric acid (7697-37-2) Paraquat (4685-14-7) Perchloric acid (7601-90-3) Phosphoric acid (7664-38-2) Plutonium (7440-07-5) Polychlorinated Biphenyls/PCBs (1336-36-3) Polyvinyl chloride/PVC (9002-86-2)

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APPENDIX B 119 Potassium hydroxide (1310-58-3) Pyridine (110-86-1) Radon (10043-92-2) Rotenone (83-79-4) Silicon (7440-21-3) Sodium bicarbonate (144-55-8) Sodium chlorate (7775-09-9) Sulfuric acid (7664-93-9) Tantalum (7440-25-7) Titanium (7440-32-6) Toluene (08-88-3) Tool steel/carbon and steel alloys Tri-Butyl Phosphate (126-73-8) Trichloroethylene/TCE (79-01-6) Trifluoroacetic anhydride (407-25-0) Uranium (7440-61-1) Uranium hexafluoride (7783-81-5) Vinyl chloride (75-01-4) Welding fumes Zinc chloride (7646-85-7) Zinc chromate (13530-65-9) Zinc chromate hydroxide (15930-94-6) 15 substances identified by the committee: 2,4- and 2,6-Dinitrotoluene (121-14-2; 606-20-2) Antimony (7440-36-0) Chloramphenicol (56-75-7) Coal Tar Pitch Volatiles (65996-93-2) Cobalt Tungsten Carbide (60674-89-7) Dibutyl Phthalate (84-74-2) Diesel Exhaust Ethylene Oxide (75-21-8) Hepatitis B o-Toluidine (95-53-4) Radium (7440-14-4) Strontium 90 (10098-97-2) Styrene (100-42-5) Tetrachloroethylene (127-18-4) Thorium (7440-29-1)

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