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Appendix C.4

Department of Health and Human Services (Biotechnology Engagement Program)

Projects facilitated by the International Science and Technology Center included the following:

Production and Specific Properties of IgA Protease Secreted by Neisseria Meningitidis (ISTC No. 0631-2p) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region

Project Agreement Date: 07/01/2003

Projected End Date: 03/24/2009

Budget: $312,307

Study of the Genetic and Serologic Diversity of Hantaviruses in the Asian Part of Russia (ISTC No. 0805-2p) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Institute of Systematics and Ecology of Animals, Novosibirsk, Khabarovsk Antiplague Station, Khabarovsk

Project Agreement Date: 01/01/2007

Projected End Date: 10/08/2010

Budget: $392,650

The Study of Prevalence, Genotype Distribution and Molecular Variability of Isolates of Hepatitis C Virus in the Siberian Part of Russia (ISTC No. 1637) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region

Project Agreement Date: 10/01/2000

Projected End Date: 04/19/2006

Budget: $692,768



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Appendix C.4 Department of Health and Human Services (Biotechnology Engagement Program) Projects facilitated by the International Science and Technology Center included the following: Production and Specific Properties of IgA Protease Secreted by Neisseria Meningitidis (ISTC No. 0631-2p) State Research Center for Applied Microbiol- ogy and Biotechnology, Obolensk, Moscow region Project Agreement Date: 07/01/2003 Projected End Date: 03/24/2009 Budget: $312,307 Study of the Genetic and Serologic Diversity of Hantaviruses in the Asian Part of Russia (ISTC No. 0805-2p) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Institute of Systematics and Ecology of Animals, Novosibirsk, Khabarovsk Antiplague Station, Khabarovsk Project Agreement Date: 01/01/2007 Projected End Date: 10/08/2010 Budget: $392,650 The Study of Prevalence, Genotype Distribution and Molecular Variability of Isolates of Hepatitis C Virus in the Siberian Part of Russia (ISTC No. 1637) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 10/01/2000 Projected End Date: 04/19/2006 Budget: $692,768 157

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158 APPENDIX C.4 Combinatorial Antibody Libraries to Orthopoxviruses (ISTC No. 1638) State Research Center of Virology and Biotechnology Vector/Research Institute of Bio- engineering, Koltsovo, Novosibirsk region Project Agreement Date: 08/01/2001 Projected End Date: 07/15/2011 Budget: $227,294 (cofunded with Defense Threat Reduction Agency) Drug-resistant Strains of M. Tuberculosis: Genetic Analysis (ISTC No. 1642) State Research Center for Applied Microbiology, Obolensk, Moscow region Project Agreement Date: 10/01/2000 Projected End Date: 04/16/2003 Budget: $102,500 Development and Certification of National Reference and Control Hbsag Serum Panels for Evaluating the Quality of Hepatitis B Diagnostics in Russia (ISTC No. 1803) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk reg., Tarasevich State Standardization and Control of Medical Preparations Research Institute, Moscow Project Agreement Date: 10/01/2002 Projected End Date: 02/07/2007 Budget: $351,320 Comparative Mycobacterial Genomics: Unraveling Differences of Func- tional and Diagnostic Importance by Subtractive Hybridization (ISTC No. 1845) State Research Center for Applied Microbiology, Obolensk, Institute of Bioorganic Chemistry, Moscow Project Agreement Date: 10/01/2000 Projected End Date: 03/13/2003 Budget: $105,000 Development of Technology for Production of Nutrient Media for Isolation and Drug Susceptibility Testing of M. Tuberculosis (ISTC No. 1846) State Research Center for Applied Microbiology, Obolensk Project Agreement Date: 10/01/2000 Projected End Date: 11/13/2003 Budget: $242,000 Development of Legal, Organizational and Scientific Concept for the Establishment of the International Center for the Study of Emerging and Reemerging Infectious Diseases (ICERID) at the State Research Center of Virology and Biotechnology Vector (ISTC No. 1884) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region

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APPENDIX C.4 159 Project Agreement Date: 10/01/2000 Projected End Date: 04/19/2005 Budget: $271,262 Epidemiology of Drug-Resistant Tuberculosis in Western Siberia: Determin- ing the Distribution and Genetic Characteristics of Drug-Resistant Myco- bacterium Tuberculosis Isolates in the Novosibirsk Oblast (ISTC No. 1980) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novo- sibirsk reg., Boreskov Institute of Catalysis/Novosibirsk Institute of Bioorganic Chemistry, Akademgorodok, Novosibirsk region Project Agreement Date: 01/01/2002 Projected End Date: 01/16/2008 Budget: $445,000 Conservation of Genetic Material and Study of Genomic Structure of Differ- ent Variola Virus Strains (ISTC No. 1987) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 03/01/2001 Projected End Date: 07/15/2011 Budget: $1,336,913 (cofunded with the Defense Threat Reduction Agency) Search for Antivirals for Treating and Prevention of Orthopoxviral Infec- tions Including Smallpox (ISTC No. 1989) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Engelhardt Institute of Molecular Biology, Moscow, Ural State Technical University, Ekaterinburg Project Agreement Date: 03/01/2001 Projected End Date: 07/15/2011 Budget: $1,368,362.05 (cofunded with the Defense Threat Reduction Agency) Biochip Application in TB Diagnostics for Fast Discrimination and Strain Typing of Multidrug-Resistant Tuberculosis in Russia (ISTC No. 2019) Engelhardt Institute of Molecular Biology, Moscow, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 04/01/2001 Projected End Date: 11/9/2005 Budget: $678,000 The Development and Application of Methods to Control Emergent/ Re-emergent Vector-Borne Diseases in Russia and the USA with Special Attention to West Nile Encephalitis (ISTC No. 2087) Ivanovsky Institute of Virology, Moscow, Central Research Institute of Epidemiology, Moscow, State

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160 APPENDIX C.4 Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 10/01/2001 Projected End Date: 04/27/2006 Budget: $1,051,365 Development of Rabies Control System in Wild Carnivora and Stray Dogs in the Russian Federation (ISTC No. 2090) Pokrov Plant of Biopreparations, Pokrov, Vladimir region Project Agreement Date: 07/01/2004 Projected End Date: 05/20/2009 Budget: $618,520 Designing, Engineering and Biological Testing of Multi-CTL Epitope-Based DNA Vaccine Against HIV-1 (ISTC No. 2153) State Research Center of Virol- ogy and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 10/01/2002 Projected End Date: 12/21/2005 Budget: $257,458 Diversity of Strains of Measles and Mumps Viruses in Russia (ISTC No. 2168) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 01/01/2002 Projected End Date: 01/16/2008 Budget: $1,317,400 Synthesis, Characterization of Targeted Delivery to Macrophage Recep- tors and Evaluation of Anti-Tubercular Activity of the Conjugates of Anti- Tubercular Antibiotics with Ligands to Macrophage (ISTC No. 2174) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Novosibirsk Institute of Tuberculosis, Novosibirsk Project Agreement Date: 10/01/2002 Projected End Date: 07/08/2006 Budget: $450,000 A Therapeutic Autologous HIV Vaccine on the Basis of a Membranitropic Preparation and the HIV-1/2 Strain in the HIV Patient (ISTC No. 2175) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 01/10/2001 Projected End Date: 02/15/2006 Budget: $330,000

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APPENDIX C.4 161 Mycobacterium Tuberculosis Cytokines: Structure and Role in Tuberculosis Latency (ISTC No. 2201) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region, Russian Academy of Sciences/A. N. Bach Institute of Biochemistry, Moscow Project Agreement Date: 10/01/2002 Projected End Date: 02/12/2008 Budget: $700,000 Characterizations and Comparisons of Bartonella Strains of Animal and Human Origins from Russia and the USA (ISTC No. 2223) Gamalei Institute of Epidemiology and Microbiology, Moscow, Moscow Medical Academy, Moscow Project Agreement Date: 10/01/2003 Projected End Date: 11/21/2008 Budget: $490,000 Comparative Mycobacterial Genomics: Unraveling Differences of Func- tional and Diagnostic Importance by Subtractive Hybridization (ISTC No. 2225) State Research Center for Applied Microbiology and Biotechnology, Obo- lensk, Moscow reg., Institute of Bioorganic Chemistry, Moscow Project Agreement Date: 10/01/2001 Projected End Date: 11/10/2006 Budget: $468,372 Catalytic Antibody Approach in Development of New Antiviral Therapeutics (ISTC No. 2226) Institute of Bioorganic Chemistry, Moscow, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region Project Agreement Date: 07/01/2003 Projected End Date: 04/18/2012 Budget: $576,827 Construction of Recombinant Plasmids Encoding Synthesis of Pathogenic Microorganism Protective Antigens and Study of Their Properties (ISTC No. 2237) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region Project Agreement Date: 04/01/2002 Projected End Date: 01/10/2008 Budget: $596,550 Integrated Preclinical/Clinical Aids Vaccine Development (ISTC No. 2344) Institute of Highly Pure Biopreparations, St. Petersburg Project Agreement Date: 10/01/2002 Projected End Date: 09/25/2006 Budget: $710,000

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162 APPENDIX C.4 Development of a Candidate Vaccine Capable of Eliciting Protective Humoral and Cell-Mediated Responses to a Broad Range of HIV-1 Variants (ISTC No. 2450) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Institute of Highly Pure Biopreparations, St. Petersburg Project Agreement Date: 10/01/2002 Projected End Date: 03/11/2008 Budget: $468,822 Surveillance on Prevalence and Molecular Mechanisms of Antimicrobial Resistance Among Streptococcus Pneumoniae in Russia Federation (ISTC No. 2460) State Research Center of Antibiotics, Moscow Project Agreement Date: 04/01/2004 Projected End Date: 04/29/2008 Budget: $380,000 Anti-Influenza Virus Therapeutic (ISTC No. 2464) Institute of Bioorganic Chemistry, Moscow State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 01/01/2003 Projected End Date: 06/16/2008 Budget: $817,425 Development of Oligonucleotide Microchips for Diagnostic of Human- Pathogenic Orthopoxviruses (ISTC No. 2508) State Research Center of Virol- ogy and Biotechnology Vector, Koltsovo, Novosibirsk reg., Engelhardt Institute of Molecular Biology, Moscow Project Agreement Date: 10/01/2002 Projected End Date: 04/14/2008 Budget: $849,668 The Study of Vilyui Encephalomyelitis: Identification of the Etiologic Agent; Peculiarities of Epidemiology and Prophylaxis (ISTC No. 2539) Institute of Clinical Immunology, Novosibirsk, Research Institute of Epidemiology and Microbiology, Irkutsk, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 04/01/2004 Projected End Date: 08/27/2008 Budget: $394,345 Candidate DNA-Vaccines against HIV (ISTC No. 2547) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 04/01/2003 Projected End Date: 07/25/2007 Budget: $341,250

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APPENDIX C.4 163 Study of Heat Shock Protein Functions in Lymphoid Cell Populations (ISTC No. 2627) Institute of Bioorganic Chemistry, Moscow, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region Project Agreement Date: 01/01/2004 Projected End Date: 10/22/2010 Budget: $669,936 Tuberculosis in Central Russia: Genetic Peculiarities of the Pathogen and Drug Resistance in Mycobacterium Tuberculosis (ISTC No. 2628) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Mos- cow region Project Agreement Date: 01/01/2005 Projected End Date: 06/24/2008 Budget: $251,380 Molecular Mechanisms of Ganglioside-Induced Apoptosis of T-Lymphocytes (ISTC No. 2654) Institute of Bioorganic Chemistry, Moscow, Institute of Immunological Engineer- ing, Lyubuchany, Moscow region Project Agreement Date: 01/01/2004 Projected End Date: 07/12/2012 Budget: $584,028 Test-Kit for Rapid Drug Susceptibility Testing of M. Tuberculosis (ISTC No. 2748) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region Project Agreement Date: 04/01/2004 Projected End Date: 10/6/2010 Budget: $474,600 Association of Human Lymphocyte Receptors with Membrane Lipid Rafts: Implications for Development of Anti-HIV Therapies (ISTC No. 2812) Insti- tute of Immunology, Moscow Project Agreement Date: 10/01/2004 Projected End Date: 07/02/2008 Budget: $270,000 Application of Tritium Bombardment Technique to Uncover the Structure of M1 Protein of Influenza Virus, M1-Hemagglutinin Interactions and Their Role in Viral Entry (ISTC No. 2816) Semenov Institute of Chemical Physics, Moscow, Institute of Bioorganic Chemistry, Moscow, Moscow State University/ A.N. Belozersky Institute of Physical and Chemical Biology, Moscow

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164 APPENDIX C.4 Project Agreement Date: 04/01/2004 Projected End Date: 08/04/2008 Budget: $559,970 Investigation of Analytical Approaches to Determine the Authenticity/Qual- ity of Pharmaceutical Products to Improve the Public Health by Identifying Counterfeit and Ineffective Products (ISTC No. 2829) Moscow State Univer- sity, Department of Chemistry, Moscow Project Agreement Date: 04/01/2004 Projected End Date: 07/16/2008 Budget: $471,033 Development of a Research Center for Tuberculosis Clinical Trials Through the Conduct of a Study of a Modified Treatment Regimen for WHO Cat- egory 1 Patients (ISTC No. 2879) The First Moscow State Medical University named after I.M. Sechenov/Research Institute of Phthisiopulmonology, State Research Center for Applied Microbiol- ogy and Biotechnology, Obolensk, Moscow region Project Agreement Date: 04/01/2005 Projected End Date: 06/05/2011 Budget: $1,369,509 Elaboration of Efficient Methods for Preparation of a Hepatitis A Virus Anti- gen on the Basis of a Non-Primate Cell-Adapted IVA Strain for Diagnostic and Prophylactic Purposes (ISTC No. 2899) Research Center of Molecular Diagnostics and Therapy, Moscow Project Agreement Date: 01/01/2005 Projected End Date: 07/25/2008 Budget: $346,500 Biochips for Early Diagnostics of HIV and Hepatitis B and C Viruses in Donor Blood (ISTC No. 2906) Engelhardt Institute of Molecular Biology, Moscow Project Agreement Date: 04/01/2005 Projected End Date: 07/21/2008 Budget: $399,862 Spread and Molecular Mechanisms of Resistance to Beta-Lactam Antibiotics Among Gram-Negative Bacteria in Nosocomial Infections (ISTC No. 2913) Moscow Medicine Academy, Moscow, State Research Center for Applied Micro- biology and Biotechnology, Obolensk, Moscow region Project Agreement Date: 01/01/2005 Projected End Date: 06/17/2009 Budget: $677,964

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APPENDIX C.4 165 Molecular Identification of Rubella Virus Isolates Circulating in the West Siberia (ISTC No. 2924) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 01/01/2004 Projected End Date: 03/31/2008 Budget: $297,055 The Epidemiology of Viral Gastroenteritis in Russia. Development of New Assays for Virus Detection and Characterization (ISTC No. 2935) Central Research Institute of Epidemiology, Moscow, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 01/01/2005 Projected End Date: 08/27/2010 Budget: $683,275 Antidotes to Highly Toxic Organophosphates (ISTC No. 2951) Institute of Toxicology, St. Petersburg Project Agreement Date: 04/01/2004 Projected End Date: 05/13/2005 Budget: $27,500 Further Improvement of Influenza Surveillance in Russia. Contribution in Global Influenza Pandemic Preparedness (ISTC No. 3070) Research Institute of Influenza, St. Petersburg, Ivanovsky Institute of Virology, Moscow Project Agreement Date: 04/01/2006 Projected End Date: 02/29/2012 Budget: $1,702,922 Phosphorescence Multianalyte Microanalysis of Dried Blood Spots as a Basis of Seroepidemiological Monitoring of Zoonotic Infections Transmitted by Ixodid Ticks (ISTC No. 3135) State Research Institute of Biological Instrument- Making, Moscow, Close Joint Stock Company “Immunoscreen,” Moscow Project Agreement Date: 11/01/2005 Projected End Date: 04/22/2011 Budget: $665,550 Establishing Meaningful Critical Concentrations of 2-nd Line Anti-TB Drugs for in Vitro Susceptibility Testing Based on in Vivo Efficacy in Animal Models (ISTC No. 3139) State Research Center for Applied Microbiology, Obolensk, Moscow region Project Agreement Date: 02/01/2007 Projected End Date: 01/25/2012 Budget: $651,930

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166 APPENDIX C.4 The Role of Ixodes Persulcatus’ Saliva in Lyme Disease Immunopathogenesis (ISTC No. 3171) State Research Center for Applied Microbiology and Biotech- nology, Obolensk, Moscow region Project Agreement Date: 10/01/2005 Projected End Date: 11/01/2012 Budget: $790,000 Computer-Assisted Discovery of New HIV-1 Integrase Inhibitors (ISTC No. 3197) Institute of Biomedical Chemistry, Moscow; Institute of Organic Chemistry, Moscow; Moscow State University/A.N. Belozersky Institute of Physical and Chemical Biology, Moscow Project Agreement Date: 04/01/2005 Projected End Date: 09/13/2010 Budget: $569,759 Immunologic and Structural Studies on Mammalian Cell Expressed Recom- binant HCV Envelope Proteins E1 and E2 (ISTC No. 3255) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region Project Agreement Date: 02/01/2006 Projected End Date: 04/05/2011 Budget: $540,637 Genetic Diversity of HIV-1 Circulating on the Territory of Russia (ISTC No. 3277) Scientific Research Institute of Vaccines and Serums, Moscow, Central Research Institute of Epidemiology, Moscow Project Agreement Date: 02/01/2006 Projected End Date: 09/06/2012 Budget: $616,075 Implication of the Universal PCR on Bacterial 16S Ribosomal RNA in the Blood Service and in Clinical Microbiology (ISTC No. 3359) Research Center of Toxicology and Hygienic Regulation of Biopreparations, Serpukhov, Moscow region, Ministry of Health/Blood Center, Moscow, The First Moscow State Medi- cal University named after I.M. Sechenov, Moscow Project Agreement Date: 01/01/2007 Projected End Date: 12/01/2012 Budget: $481,675 Improvement and Standardization of Laboratory and Epidemiologic Rubella Surveillance Methods in Russian Federation (ISTC No. 3373) Sci- entific Research Institute of Vaccines and Serums, Moscow, Research Institute of Influenza, St. Petersburg

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APPENDIX C.4 167 Project Agreement Date: 09/01/2006 Projected End Date: 05/18/2012 Budget: $350,145 Collection and Analysis of the Information, Creation of the Computer Data- base on Radioactive Contamination of Environments in Russia, Belarus and Ukraine at the Early Phase of the Chernobyl Accident (ISTC No. 3452) Scientific and Production Association “Typhoon,” Obninsk, Kaluga region Project Agreement Date: 11/01/2006 Projected End Date: 03/27/2009 Budget: $100,000 Development and Certification of National Reference and Control Anti-HCV Antibodies Serum Panels for Evaluating the Quality of Hepatitis C Diagnos- tics in Russia (ISTC No. 3526) State Research Center of Virology and Biotech- nology Vector, Koltsovo, Novosibirsk reg., Tarasevich State Standardization and Control of Medical Preparations Research Institute, Moscow Project Agreement Date: 04/01/2007 Projected End Date: 08/14/2012 Budget: $471,737 Salmonella Surveillance in Russian Federation (ISTC No. 3533) Central Research Institute of Epidemiology, Moscow Project Agreement Date: 01/01/2007 Projected End Date: 07/11/2012 Budget: $327,550 Development of an Oligonucleotide Microarray Chip for Typing Various Subtypes of Type A Influenza Virus (ISTC No. 3803) Siberian Branch of RAS/ Institute of Chemical Biology and Fundamental Medicine, Novosibirsk Project Agreement Date: 11/01/2007 Projected End Date: 12/01/2012 Budget: $360,000 Development of a Rapid Test for Clinical Laboratory Diagnosis of Chla- mydia Trachomatis (ISTC No. 3846) Saratov Scientific and Research Veterinary Institute, Saratov Project Agreement Date: 08/01/2008 Projected End Date: 12/31/2013 Budget: $248,130

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168 APPENDIX C.4 Analysis of T-cell Differentiation Status and the Development of a New Immunological Approach for Active TB Diagnosis and Monitoring (ISTC No. 4072) Central Tuberculosis Research Institute, Moscow Project Agreement Date: 06/01/2011 Projected End Date: 08/26/2012 Budget: $10,000 SOURCE: Information provided by ISTC, March 2012.