Department of Health and Human Services (Biotechnology Engagement Program)
Projects facilitated by the International Science and Technology Center included the following:
Production and Specific Properties of IgA Protease Secreted by Neisseria Meningitidis (ISTC No. 0631-2p) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 07/01/2003
Projected End Date: 03/24/2009
Budget: $312,307
Study of the Genetic and Serologic Diversity of Hantaviruses in the Asian Part of Russia (ISTC No. 0805-2p) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Institute of Systematics and Ecology of Animals, Novosibirsk, Khabarovsk Antiplague Station, Khabarovsk
Project Agreement Date: 01/01/2007
Projected End Date: 10/08/2010
Budget: $392,650
The Study of Prevalence, Genotype Distribution and Molecular Variability of Isolates of Hepatitis C Virus in the Siberian Part of Russia (ISTC No. 1637) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 10/01/2000
Projected End Date: 04/19/2006
Budget: $692,768
Combinatorial Antibody Libraries to Orthopoxviruses (ISTC No. 1638) State Research Center of Virology and Biotechnology Vector/Research Institute of Bio-engineering, Koltsovo, Novosibirsk region
Project Agreement Date: 08/01/2001
Projected End Date: 07/15/2011
Budget: $227,294 (cofunded with Defense Threat Reduction Agency)
Drug-resistant Strains of M. Tuberculosis: Genetic Analysis (ISTC No. 1642) State Research Center for Applied Microbiology, Obolensk, Moscow region Project Agreement Date: 10/01/2000
Projected End Date: 04/16/2003
Budget: $102,500
Development and Certification of National Reference and Control Hbsag Serum Panels for Evaluating the Quality of Hepatitis B Diagnostics in Russia (ISTC No. 1803) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk reg., Tarasevich State Standardization and Control of Medical Preparations Research Institute, Moscow
Project Agreement Date: 10/01/2002
Projected End Date: 02/07/2007
Budget: $351,320
Comparative Mycobacterial Genomics: Unraveling Differences of Functional and Diagnostic Importance by Subtractive Hybridization (ISTC No. 1845) State Research Center for Applied Microbiology, Obolensk, Institute of Bioorganic Chemistry, Moscow
Project Agreement Date: 10/01/2000
Projected End Date: 03/13/2003
Budget: $105,000
Development of Technology for Production of Nutrient Media for Isolation and Drug Susceptibility Testing of M. Tuberculosis (ISTC No. 1846) State Research Center for Applied Microbiology, Obolensk
Project Agreement Date: 10/01/2000
Projected End Date: 11/13/2003
Budget: $242,000
Development of Legal, Organizational and Scientific Concept for the Establishment of the International Center for the Study of Emerging and Reemerging Infectious Diseases (ICERID) at the State Research Center of Virology and Biotechnology Vector (ISTC No. 1884) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 10/01/2000
Projected End Date: 04/19/2005
Budget: $271,262
Epidemiology of Drug-Resistant Tuberculosis in Western Siberia: Determining the Distribution and Genetic Characteristics of Drug-Resistant Mycobacterium Tuberculosis Isolates in the Novosibirsk Oblast (ISTC No. 1980) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk reg., Boreskov Institute of Catalysis/Novosibirsk Institute of Bioorganic Chemistry, Akademgorodok, Novosibirsk region
Project Agreement Date: 01/01/2002
Projected End Date: 01/16/2008
Budget: $445,000
Conservation of Genetic Material and Study of Genomic Structure of Different Variola Virus Strains (ISTC No. 1987) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 03/01/2001
Projected End Date: 07/15/2011
Budget: $1,336,913 (cofunded with the Defense Threat Reduction Agency)
Search for Antivirals for Treating and Prevention of Orthopoxviral Infections Including Smallpox (ISTC No. 1989) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Engelhardt Institute of Molecular Biology, Moscow, Ural State Technical University, Ekaterinburg
Project Agreement Date: 03/01/2001
Projected End Date: 07/15/2011
Budget: $1,368,362.05 (cofunded with the Defense Threat Reduction Agency)
Biochip Application in TB Diagnostics for Fast Discrimination and Strain Typing of Multidrug-Resistant Tuberculosis in Russia (ISTC No. 2019)
Engelhardt Institute of Molecular Biology, Moscow, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 04/01/2001
Projected End Date: 11/9/2005
Budget: $678,000
The Development and Application of Methods to Control Emergent/Re-emergent Vector-Borne Diseases in Russia and the USA with Special Attention to West Nile Encephalitis (ISTC No. 2087) Ivanovsky Institute of Virology, Moscow, Central Research Institute of Epidemiology, Moscow, State
Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 10/01/2001
Projected End Date: 04/27/2006
Budget: $1,051,365
Development of Rabies Control System in Wild Carnivora and Stray Dogs in the Russian Federation (ISTC No. 2090) Pokrov Plant of Biopreparations, Pokrov, Vladimir region
Project Agreement Date: 07/01/2004
Projected End Date: 05/20/2009
Budget: $618,520
Designing, Engineering and Biological Testing of Multi-CTL Epitope-Based DNA Vaccine Against HIV-1 (ISTC No. 2153) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 10/01/2002
Projected End Date: 12/21/2005
Budget: $257,458
Diversity of Strains of Measles and Mumps Viruses in Russia (ISTC No. 2168) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 01/01/2002
Projected End Date: 01/16/2008
Budget: $1,317,400
Synthesis, Characterization of Targeted Delivery to Macrophage Receptors and Evaluation of Anti-Tubercular Activity of the Conjugates of Anti-Tubercular Antibiotics with Ligands to Macrophage (ISTC No. 2174) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Novosibirsk Institute of Tuberculosis, Novosibirsk
Project Agreement Date: 10/01/2002
Projected End Date: 07/08/2006
Budget: $450,000
A Therapeutic Autologous HIV Vaccine on the Basis of a Membranitropic Preparation and the HIV-1/2 Strain in the HIV Patient (ISTC No. 2175) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 01/10/2001
Projected End Date: 02/15/2006
Budget: $330,000
Mycobacterium Tuberculosis Cytokines: Structure and Role in Tuberculosis Latency (ISTC No. 2201) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region, Russian Academy of Sciences/A. N. Bach Institute of Biochemistry, Moscow
Project Agreement Date: 10/01/2002
Projected End Date: 02/12/2008
Budget: $700,000
Characterizations and Comparisons of Bartonella Strains of Animal and Human Origins from Russia and the USA (ISTC No. 2223) Gamalei Institute of Epidemiology and Microbiology, Moscow, Moscow Medical Academy, Moscow
Project Agreement Date: 10/01/2003
Projected End Date: 11/21/2008
Budget: $490,000
Comparative Mycobacterial Genomics: Unraveling Differences of Functional and Diagnostic Importance by Subtractive Hybridization (ISTC No. 2225) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow reg., Institute of Bioorganic Chemistry, Moscow
Project Agreement Date: 10/01/2001
Projected End Date: 11/10/2006
Budget: $468,372
Catalytic Antibody Approach in Development of New Antiviral Therapeutics (ISTC No. 2226) Institute of Bioorganic Chemistry, Moscow, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 07/01/2003
Projected End Date: 04/18/2012
Budget: $576,827
Construction of Recombinant Plasmids Encoding Synthesis of Pathogenic Microorganism Protective Antigens and Study of Their Properties (ISTC No. 2237) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 04/01/2002
Projected End Date: 01/10/2008
Budget: $596,550
Integrated Preclinical/Clinical Aids Vaccine Development (ISTC No. 2344) Institute of Highly Pure Biopreparations, St. Petersburg
Project Agreement Date: 10/01/2002
Projected End Date: 09/25/2006
Budget: $710,000
Development of a Candidate Vaccine Capable of Eliciting Protective Humoral and Cell-Mediated Responses to a Broad Range of HIV-1 Variants (ISTC No. 2450) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Institute of Highly Pure Biopreparations, St. Petersburg
Project Agreement Date: 10/01/2002
Projected End Date: 03/11/2008
Budget: $468,822
Surveillance on Prevalence and Molecular Mechanisms of Antimicrobial Resistance Among Streptococcus Pneumoniae in Russia Federation (ISTC No. 2460) State Research Center of Antibiotics, Moscow
Project Agreement Date: 04/01/2004
Projected End Date: 04/29/2008
Budget: $380,000
Anti-Influenza Virus Therapeutic (ISTC No. 2464) Institute of Bioorganic Chemistry, Moscow State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 01/01/2003
Projected End Date: 06/16/2008
Budget: $817,425
Development of Oligonucleotide Microchips for Diagnostic of Human-Pathogenic Orthopoxviruses (ISTC No. 2508) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk reg., Engelhardt Institute of Molecular Biology, Moscow
Project Agreement Date: 10/01/2002
Projected End Date: 04/14/2008
Budget: $849,668
The Study of Vilyui Encephalomyelitis: Identification of the Etiologic Agent; Peculiarities of Epidemiology and Prophylaxis (ISTC No. 2539) Institute of Clinical Immunology, Novosibirsk, Research Institute of Epidemiology and Microbiology, Irkutsk, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 04/01/2004
Projected End Date: 08/27/2008
Budget: $394,345
Candidate DNA-Vaccines against HIV (ISTC No. 2547) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 04/01/2003
Projected End Date: 07/25/2007
Budget: $341,250
Study of Heat Shock Protein Functions in Lymphoid Cell Populations (ISTC No. 2627)
Institute of Bioorganic Chemistry, Moscow, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 01/01/2004
Projected End Date: 10/22/2010
Budget: $669,936
Tuberculosis in Central Russia: Genetic Peculiarities of the Pathogen and Drug Resistance in Mycobacterium Tuberculosis (ISTC No. 2628) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 01/01/2005
Projected End Date: 06/24/2008
Budget: $251,380
Molecular Mechanisms of Ganglioside-Induced Apoptosis of T-Lymphocytes (ISTC No. 2654)
Institute of Bioorganic Chemistry, Moscow, Institute of Immunological Engineering, Lyubuchany, Moscow region
Project Agreement Date: 01/01/2004
Projected End Date: 07/12/2012
Budget: $584,028
Test-Kit for Rapid Drug Susceptibility Testing of M. Tuberculosis (ISTC No. 2748) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 04/01/2004
Projected End Date: 10/6/2010
Budget: $474,600
Association of Human Lymphocyte Receptors with Membrane Lipid Rafts: Implications for Development of Anti-HIV Therapies (ISTC No. 2812) Institute of Immunology, Moscow
Project Agreement Date: 10/01/2004
Projected End Date: 07/02/2008
Budget: $270,000
Application of Tritium Bombardment Technique to Uncover the Structure of M1 Protein of Influenza Virus, M1-Hemagglutinin Interactions and Their Role in Viral Entry (ISTC No. 2816) Semenov Institute of Chemical Physics, Moscow, Institute of Bioorganic Chemistry, Moscow, Moscow State University/A.N. Belozersky Institute of Physical and Chemical Biology, Moscow
Project Agreement Date: 04/01/2004
Projected End Date: 08/04/2008
Budget: $559,970
Investigation of Analytical Approaches to Determine the Authenticity/Quality of Pharmaceutical Products to Improve the Public Health by Identifying Counterfeit and Ineffective Products (ISTC No. 2829) Moscow State University, Department of Chemistry, Moscow
Project Agreement Date: 04/01/2004
Projected End Date: 07/16/2008
Budget: $471,033
Development of a Research Center for Tuberculosis Clinical Trials Through the Conduct of a Study of a Modified Treatment Regimen for WHO Category 1 Patients (ISTC No. 2879)
The First Moscow State Medical University named after I.M. Sechenov/Research Institute of Phthisiopulmonology, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 04/01/2005
Projected End Date: 06/05/2011
Budget: $1,369,509
Elaboration of Efficient Methods for Preparation of a Hepatitis A Virus Antigen on the Basis of a Non-Primate Cell-Adapted IVA Strain for Diagnostic and Prophylactic Purposes (ISTC No. 2899) Research Center of Molecular Diagnostics and Therapy, Moscow
Project Agreement Date: 01/01/2005
Projected End Date: 07/25/2008
Budget: $346,500
Biochips for Early Diagnostics of HIV and Hepatitis B and C Viruses in Donor Blood (ISTC No. 2906) Engelhardt Institute of Molecular Biology, Moscow
Project Agreement Date: 04/01/2005
Projected End Date: 07/21/2008
Budget: $399,862
Spread and Molecular Mechanisms of Resistance to Beta-Lactam Antibiotics Among Gram-Negative Bacteria in Nosocomial Infections (ISTC No. 2913) Moscow Medicine Academy, Moscow, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 01/01/2005
Projected End Date: 06/17/2009
Budget: $677,964
Molecular Identification of Rubella Virus Isolates Circulating in the West Siberia (ISTC No. 2924) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 01/01/2004
Projected End Date: 03/31/2008
Budget: $297,055
The Epidemiology of Viral Gastroenteritis in Russia. Development of New Assays for Virus Detection and Characterization (ISTC No. 2935) Central Research Institute of Epidemiology, Moscow, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 01/01/2005
Projected End Date: 08/27/2010
Budget: $683,275
Antidotes to Highly Toxic Organophosphates (ISTC No. 2951) Institute of Toxicology, St. Petersburg
Project Agreement Date: 04/01/2004
Projected End Date: 05/13/2005
Budget: $27,500
Further Improvement of Influenza Surveillance in Russia. Contribution in Global Influenza Pandemic Preparedness (ISTC No. 3070) Research Institute of Influenza, St. Petersburg, Ivanovsky Institute of Virology, Moscow
Project Agreement Date: 04/01/2006
Projected End Date: 02/29/2012
Budget: $1,702,922
Phosphorescence Multianalyte Microanalysis of Dried Blood Spots as a Basis of Seroepidemiological Monitoring of Zoonotic Infections Transmitted by Ixodid Ticks (ISTC No. 3135) State Research Institute of Biological Instrument-Making, Moscow, Close Joint Stock Company “Immunoscreen,” Moscow
Project Agreement Date: 11/01/2005
Projected End Date: 04/22/2011
Budget: $665,550
Establishing Meaningful Critical Concentrations of 2-nd Line Anti-TB Drugs for in Vitro Susceptibility Testing Based on in Vivo Efficacy in Animal Models (ISTC No. 3139)
State Research Center for Applied Microbiology, Obolensk, Moscow region
Project Agreement Date: 02/01/2007
Projected End Date: 01/25/2012
Budget: $651,930
The Role of Ixodes Persulcatus’ Saliva in Lyme Disease Immunopathogenesis (ISTC No. 3171) State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region
Project Agreement Date: 10/01/2005
Projected End Date: 11/01/2012
Budget: $790,000
Computer-Assisted Discovery of New HIV-1 Integrase Inhibitors (ISTC No. 3197)
Institute of Biomedical Chemistry, Moscow; Institute of Organic Chemistry, Moscow; Moscow State University/A.N. Belozersky Institute of Physical and Chemical Biology, Moscow
Project Agreement Date: 04/01/2005
Projected End Date: 09/13/2010
Budget: $569,759
Immunologic and Structural Studies on Mammalian Cell Expressed Recombinant HCV Envelope Proteins E1 and E2 (ISTC No. 3255) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region
Project Agreement Date: 02/01/2006
Projected End Date: 04/05/2011
Budget: $540,637
Genetic Diversity of HIV-1 Circulating on the Territory of Russia (ISTC No. 3277) Scientific Research Institute of Vaccines and Serums, Moscow, Central Research Institute of Epidemiology, Moscow
Project Agreement Date: 02/01/2006
Projected End Date: 09/06/2012
Budget: $616,075
Implication of the Universal PCR on Bacterial 16S Ribosomal RNA in the Blood Service and in Clinical Microbiology (ISTC No. 3359) Research Center of Toxicology and Hygienic Regulation of Biopreparations, Serpukhov, Moscow region, Ministry of Health/Blood Center, Moscow, The First Moscow State Medical University named after I.M. Sechenov, Moscow
Project Agreement Date: 01/01/2007
Projected End Date: 12/01/2012
Budget: $481,675
Improvement and Standardization of Laboratory and Epidemiologic Rubella Surveillance Methods in Russian Federation (ISTC No. 3373) Scientific Research Institute of Vaccines and Serums, Moscow, Research Institute of Influenza, St. Petersburg
Project Agreement Date: 09/01/2006
Projected End Date: 05/18/2012
Budget: $350,145
Collection and Analysis of the Information, Creation of the Computer Database on Radioactive Contamination of Environments in Russia, Belarus and Ukraine at the Early Phase of the Chernobyl Accident (ISTC No. 3452) Scientific and Production Association “Typhoon,” Obninsk, Kaluga region Project Agreement Date: 11/01/2006 Projected End Date: 03/27/2009 Budget: $100,000
Development and Certification of National Reference and Control Anti-HCV Antibodies Serum Panels for Evaluating the Quality of Hepatitis C Diagnostics in Russia (ISTC No. 3526) State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk reg., Tarasevich State Standardization and Control of Medical Preparations Research Institute, Moscow
Project Agreement Date: 04/01/2007
Projected End Date: 08/14/2012
Budget: $471,737
Salmonella Surveillance in Russian Federation (ISTC No. 3533) Central Research Institute of Epidemiology, Moscow
Project Agreement Date: 01/01/2007
Projected End Date: 07/11/2012
Budget: $327,550
Development of an Oligonucleotide Microarray Chip for Typing Various Subtypes of Type A Influenza Virus (ISTC No. 3803) Siberian Branch of RAS/Institute of Chemical Biology and Fundamental Medicine, Novosibirsk
Project Agreement Date: 11/01/2007
Projected End Date: 12/01/2012
Budget: $360,000
Development of a Rapid Test for Clinical Laboratory Diagnosis of Chlamydia Trachomatis (ISTC No. 3846) Saratov Scientific and Research Veterinary Institute, Saratov
Project Agreement Date: 08/01/2008
Projected End Date: 12/31/2013
Budget: $248,130
Analysis of T-cell Differentiation Status and the Development of a New Immunological Approach for Active TB Diagnosis and Monitoring (ISTC No. 4072) Central Tuberculosis Research Institute, Moscow
Project Agreement Date: 06/01/2011
Projected End Date: 08/26/2012
Budget: $10,000
SOURCE: Information provided by ISTC, March 2012.